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  • 550 - Earth sciences
  • Lunar and Planetary Science and Exploration
  • Mice
  • Springer  (16)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 71 (1985), S. 44-51 
    ISSN: 1432-2242
    Keywords: Heterosis ; Mice ; Selection ; Growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary To examine the effect of selection on levels of heterosis, crosses were made between three groups of six lines of mice, one group unselected (controls) and the other two selected for high (large lines) and low (small lines) 6-week body weight, respectively. The coefficient of inbreeding of each line was about 0.60. Each line was crossed reciprocally to one line from each of the parental groups, as well as producing purebred progeny. Heterosis for 3-week weight, 6-week weight and 3–6 week gain averaged 0.0%, 2.4% and 4.2%, respectively, and was higher for males than for females. Heterosis was more extensive in crosses involving large or control lines than in crosses with small lines. There was no detectable heterosis in several measures of developmental rate, such as age at vaginal opening. Food conversion efficiency and carcass composition were measured on a sample of the animals. Food consumption, gonadal fat pad weight, and hindquarters weight, each expressed as a proportion of body weight, exhibited −4.0%, 5.6%, and 2.3% heterosis, respectively.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 174 (1994), S. 13-26 
    ISSN: 1432-1351
    Keywords: Insects ; Antennae ; Toads ; Mice ; Mantids ; Spiders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract 1. Interactions of cockroaches with 4 different predator species were recorded by videography. Some predators, especially spiders, struck from relatively short distances and usually contacted a cockroach prior to initiation of escape (Table 1, Fig. 3). This touch frequently occurred on an antenna. Cockroaches turned away from the side on which an antenna was touched. 2. We then measured the success of escape from predators for cockroaches with either cerci or antennae ablated. Only antennal removal caused a significant decrease in the success of escape from spiders (Fig. 5). 3. With controlled stimuli, cockroaches responded reliably to abrupt touch of antennae, legs or body (Fig. 6). Responses resembled wind-elicited escape: they consisted of a short latency turn (away from the stimulus) followed by running (Figs. 7, 8). However, lesions show that touchevoked escape does not depend on the giant interneuron system (Table 2). 4. Following section of one cervical connective, cockroaches continued to respond to touching either antenna, but often turned inappropriately toward, rather than away from, stimuli applied to the antenna contralateral to the severed connective (Table 3, Fig. 10). 5. For certain types of predators touch may be a primary cue by which cockroaches detect predatory attack. Descending somatosensory pathways for escape are distinct from the GI system.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 71 (1985), S. 52-56 
    ISSN: 1432-2242
    Keywords: Heterosis ; Reproduction ; Mice ; Body weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary To examine the effect of selection for body weight on levels of heterosis for reproductive traits, crosses were made between three groups of six lines of mice, one group unselected (controls) and the other two selected for high (large lines) and low (small lines) 6-week body weight, respectively. The coefficient of inbreeding of each line was about 0.60. In a comparison of purebred and crossbred progeny, both out of purebred mothers, there was on average 4% heterosis for number born, 3% for percentage weaned and 8% for numbers weaned. In a comparison of purebred and crossbred mothers, each mated to males of an unrelated strain and dissected on the 17th day of gestation, crossbreds had on average 1.6 more live embryos, which was 22% of the purebred mean. This comprised an increase of 0.6 corpora lutea, of 0.4 in survival to implantation and of 0.6 in subsequent survival to 17 days. The heterosis was similar whether the mothers had parents of the same or different size.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 73 (1987), S. 926-931 
    ISSN: 1432-2242
    Keywords: Selection ; Feeding levels ; Growth ; Body composition ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Two lines of mice were selected for high post-weaning weight gain (3 to 6 weeks) adjusted for 3 week weight. One line (F) was grown on freely available food and the other (S) on a feeding scale set at the same level for all mice. Food intake of the S line averaged 80% of the F line. The realised heritabilities after 6 generations of selection were 0.38±0.06 and 0.33±0.07 for the F and S lines, respectively. In generation 7, mice from the F and S lines and from an unselected control line (C) were compared on both free and set levels of feeding from 3 weeks to 9 weeks of age. Measurements taken were growth rate, appetite, food conversion efficiency (weight gain/food intake) and body composition (fat, protein, ash, water). The F and S lines grew more rapidly and efficiently than the C line on both levels of feeding, each line performing best on the level of feeding on which it was selected. The average genetic correlation between growth rates of the same line on the two feeding levels was 0.54±0.10. The F line grew 19% faster and was 9% more efficient than the S line on free feeding but the S line grew 15% faster and was 15% more efficient than the F line on set feeding. Relative to the C line, food intake per day on free feeding was 4% higher in the F line and 6% lower in the S line. There was no difference between the lines in food intake/g body weight. The rate of deposition of all body components increased in both selection lines. In the F, S and C lines respectively, efficiencies of gains in body components (102x gain/food) were 1.79, 1.31 and 1.06 for fat, 1.53, 1.63 and 1.22 for protein and 5.88, 6.45 and 4.98 for protein + water. Apparently energy lost as heat was reduced in both the F and S lines. The partitioning of energy retained was altered in favour of more fat in the F line and more protein in the S line.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Plant foods for human nutrition 45 (1994), S. 277-285 
    ISSN: 1573-9104
    Keywords: Bread ; Flour ; Fortification ; Iron ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Bread made from starch, unenriched, enriched, super-enriched and whole wheat flour was fed to male weanling mice for 21 days to explore the effect on iron utilization using liver, blood iron status and iron balance as parameters of evaluation. The results indicated that iron retentions, blood hemoglobin and hematocrit levels, and liver iron concentration numerically tended to be greater in mice fed super enriched bread than in mice fed the enriched bread but, for most parameters, these differences were not found to be statistically significant. Iron absorption from whole wheat bread was significantly poorer than the super enriched or enriched white wheat bread rations.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 253-254 
    ISSN: 1420-9071
    Keywords: Mice ; heritable mutations ; sperm enzyme activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Male mice were injected i.p. with 2.5 mg/kg mitomycin C, 100 mg/kg ethyl nitrosourea or saline and mated with untreated virgin females five weeks later. Sperm from 64 of the F1 male progeny were analyzed histochemically for acrosin, succinic dehydrogenase and alpha-glycerophosphate dehydrogenase activity. The frequency of F1 males with sub-normal sperm enzyme activity was significantly higher among progeny from treated males than in controls. These results show that analysis of sperm enzyme activity in F1 males is a practical method for detection of transmitted mutations induced in a treated parent.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Behavior genetics 14 (1984), S. 1-19 
    ISSN: 1573-3297
    Keywords: Mice ; alcohol ; selective breeding ; pharmacogenetics ; biometrical genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A classical Mendelian cross was derived from Long-Sleep (LS) and Short-Sleep (SS) mice, lines selectively bred for differences in response to hypnotic doses of ethanol (ETOH). Biometrical genetic procedures applied to the selection phenotype, namely, duration of the ETOH-induced loss of the righting reflex, suggest that a simple additive genetic system controls this depressant response. Sex differences were present in the Mendelian cross generations that had the longest duration responses. An estimate of the number of loci differentiated by the selection was nine. Blood ethanol levels at the time of regaining the righting reflex in the seven genotypes of the Mendelian cross showed that the selection operated solely by changing tissue sensitivity to ethanol.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 81 (1991), S. 685-692 
    ISSN: 1432-2242
    Keywords: IGF-1 ; Body weight ; Realized heritability ; Genetic correlation ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five generations of divergent selection for plasma concentration of insulin-like growth factor-1 (IGF-1) and for 12-week body weight were carried out in mice, including randomly selected control lines for each trait. All lines were replicated once (12 lines in total). Each replicate line consisted of eight male and eight female parents per generation. Litter size was standardized to eight pups at birth. Mass selection was applied in the selected lines and within-family random selection in the control lines. Blood was taken from the orbital sinus of individual mice at 12 weeks of age for IGF-1 assay. Realized heritabilities were 0.10±0.01 for IGF-1 and 0.41 ± 0.02 for 12-week weight. The realized genetic correlation between IGF-1 and 12-week weight was 0.58 ± 0.01, with a phenotypic correlation of 0.38. Although the genetic correlation between IGF-1 and body weight in mice is moderately positive, 12-week weight responded 3.5 times as fast to weight selection as to selection for IGF-1.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 71 (1985), S. 250-257 
    ISSN: 1432-2242
    Keywords: Mice ; Lifetime ; Performance ; Additive ; Maternal ; Heterosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A total of 2,457 lifetime performance records of 29 genetic groups of mice was analyzed using multiple regression of records on the proportion of gene contribution from 6 lines (designated as Lines MP, mQ, WP, wQ, CP and cQ). Genetic effects were partitioned into line additive, line maternal, direct heterosis, maternal heterosis and paternal heterosis effects. The line additive and line maternal effects were expressed as deviations from Line cQ. Seventeen of 25 line additive effects differed significantly (P〈0.05) from Line cQ whereas only 4 of 25 line maternal effects deviated significantly from Line cQ. Deviations in line additive effects from cQ were negative in all lines examined whereas deviations in line maternal effects from cQ were all positive, indicating a negative relationship between line additive and line maternal effects. Direct heterosis effects were all positive and significant (P 〈 0.01) except in the MPxWP cross which was produced by mating Lines MP and WP of the same base population (P). Maternal heterosis effects were significant in 10 of 20 cases whereas paternal heterosis effects were significant in 13 of 20 cases. Although direct heterosis is a major component of total heterosis effects (sum of direct, maternal and paternal heterosis), the results suggest that parental heterosis may need to be considered in producing multiple way crosses. The fitting of line additive, line maternal, direct heterosis, maternal heterosis and paternal heterosis effects in the multiple regression model effectively accounted for all genetic effects in lifetime performance.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 59 (1981), S. 129-137 
    ISSN: 1432-2242
    Keywords: Selection ; Mice ; Feeding Efficiency ; Correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Selection was practised for improved feed efficiency (gain/feed intake) of mice on two alternative feeding regimes. In one set of lines animals were fed ad libitum, in the other set they were individually fed a fixed amount of feed (about 10% below the control ad libitum intake) which was not changed over generations. For each treatment, a pair of replicate lines (E) were selected on efficiency from 3–5 weeks of age for 8 generations and another pair (L) from 5–7 weeks for 7 generations. A control line was maintained for both E and L lines. In terminal generations mice from each line were tested on each feeding regime, and carcasses of ad libitum fed mice were analysed. The realized heritability (within families) for efficiency averaged 13%, without much variation over treatments. In the E lines efficiency increased by about 18% of the control mean and in the L lines by about 60%, although absolute changes were small, and responses were similar on the two feeding regimes. Weights at the start of test decreased in the E lines and increased in the L lines; weights at the end of test increased in both. When tested on the alternative regimes, no interactions were detected for live weights, weight gains or efficiency; selection under fixed intake led to the same increase in appetite as did that under ad libitum. There were no interactions for carcass composition. Selection for efficiency led to an increase in fatness on both selection regimes and both weight ranges.
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