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  • Albumin  (1)
  • Atmospheric conditions  (1)
  • Springer  (2)
  • Oxford University Press
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 32 (1988), S. 129-133 
    ISSN: 1432-1254
    Keywords: Asthma ; Atmospheric conditions ; Japan ; Model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract A point process model is suitable for analysis of a sequence of binary variables, each of which may be dependent on the preceeding one. This model was used for analysis of the correlation between the state of the atmosphere and the presence or absence of asthmatic symptom known from diaries in which a day was divided into four parts. The diaries were kept during summer and autumn of a year by 19 adult and 12 child patients in Sapporo (43°03′ N, 141°20′ E), 39 adult and 20 child patients in Tokyo (35°41′ N, 139°46′ E), and 26 adult and 18 child patients in Naha (26°14′ N, 127°41′ E). Low temperature and decrease in temperature significantly related to the asthmatic symptom during the seasons. No reversions on correlations as to temperature were observed among places, between the adult and the child, and before and after taking in effects of the preceding symptom and/or the circadian rhythm. Some correlations relating to humidity or to barometric pressure, on the other hand, reversed from place to place, from the adult to the child, and from “before” to “after” taking in the effects. Availability of this model for further study on the correlation between the air with contents and the asthmatic symptom is shortly discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-232X
    Keywords: Key words Human amniotic epithelial cells ; Cell transplantation ; Albumin ; Gene therapy ; Liver stem cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract As human amniotic epithelial tissue is formed on about the eighth day after fertilization, human amniotic epithelial cells (hAEC) may have multipotency to differentiate into various organs, such as brain, heart, or liver. In this study, we showed evidence of the synthesis and excretion of albumin by hAEC, by immunostaining and enzyme-linked immunoassay. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot analyses revealed the expression of albumin mRNA and protein, respectively. In addition, hAEC also demonstrated immunoreactivity to genetic markers of liver lineage, such as human serum albumin and α-fetoprotein. Transplanted hAEC to Scid mouse liver showed positive immunoreactivity to albumin and α-fetoprotein. Genetically modified cells containing the β-galactosidase (LacZ) gene (AxCALacZ) were integrated in liver parenchyma. Human polymorphic gene analysis in Scid mouse liver after the implantation of hAEC showed that these Scid mouse livers obviously contained this human-specific gene until day 7 after the cell transplantation. As hAEC do not cause any acute rejection by allotransplantation, we conclude that hAEC may be useful as a transgene carrier to treat patients with inherited liver diseases.
    Type of Medium: Electronic Resource
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