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  • bioavailability  (98)
  • N-nitroso-N-ethylurea
  • Oryza sativa
  • Springer  (160)
  • Institute of Physics
  • International Union of Crystallography
  • Wiley
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  • 1
    ISSN: 1573-5117
    Keywords: sediment-bound pollutants ; sediment toxicity tests ; bioavailability ; bivalves ; translocation experiments ; biomarkers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Important Cd contamination has been observed in the Gironde estuary, France, but other metallic and organic pollutants are also present. Since sediment is well-known as a major compartment for the storage of numerous pollutants in aquatic environments, its contribution as a source of pollutants for the biota has been examined according to different methodologies. Geochemical studies have provided estimates of Cd mobility particularly with decreasing pHs and increasing salinity, a result in agreement with the relative abundance of exchangeable Cd and Cd bound to carbonates shown by sequential extraction. When in vitro assays tended to be more realistic with regard to the digestion process in bivalves, Cd extraction at low pH was lowered but was still important compared to Cu or Zn. Moreover, toxicity of Gironde sediments to copepod and sea urchin larval stages (not to oyster larvae) brought indirect evidence of the bioavailability of sediment-bound pollutants. Except the aromatic compound perylene, bioaccumulation in bivalves concerns mainly metals. In oysters they were found preferentially in the soluble phase and, in the cytosol, a strong relationship between cadmium and metallothionein-like proteins has been shown, suggesting a detoxication process in this species. This hypothesis is in agreement with the fact that neither cytopathological effects in gills and digestive glands nor marked changes of condition index were observed. On the other hand, no changes in MTLP levels in mussels were induced by metal accumulation in individuals transplanted from a comparatively unpolluted area (Bay of Bourgneuf). The stability of GST activity may be related to a poor accumulation of aromatic compounds. Changes in MDA concentration, AChE and catalase activities are discussed. Mobility, bioavailability of pollutants, significant responses of biomarkers suggest a potential environmental hazard. However, since interspecific differences occur, is the risk at the level of the whole estuarine ecosystem equilibrium or is it limited to a small number of species?
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-8773
    Keywords: lead ; suspended sediment ; oyster ; bioavailability ; cytopathology ; electron probe microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two different approaches were used to study the bioavailability of sediment-bound lead. In vitro techniques simulating the potential metal desorption under conditions prevailing in the digestive tract were assayed on a contaminated sediment. An experimental model of a food chain was designed to determine the retention of lead in the soft tissues of oysters according to the environmental source of the metal (water or sediment). Neither enzymatic action nor leaching at low pH (both aspects of digestion) induce the release of important lead amounts from particles. Therefore, after 3 weeks of exposure, the retention of lead from the trophic source is lower (1%) compared with direct contamination (5%). Lysosomes are the major intracellular structures responsible for lead storage in the gills, digestive tract and digestive gland. The abundance of lysosomes and their lead amount vary according to the gross concentrations in the soft tissues. The cytopathological data are in agreement with the results about lead accumulation: in oysters exposed to sediment-bound lead, impairments are not so marked as in individuals contaminated directly from water but the same organelles are concerned. Mitochondrial impairments may be related to the effect of lead on cellular respiration processes and changes involving the granular endoplasmic reticulum may have an effect on the level of protein synthesis. Cellular extrusions carrying away numerous lysosomes loaded with lead could account for the balancing of lead incorporation between 2 and 3 weeks of exposure.
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  • 3
    ISSN: 1432-1041
    Keywords: Prednisone ; Prednisolone metasulfobenzoate ; bioavailability ; intestinal infusion ; absorption ; presystemic clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The role of intestinal absorption in the differential availability of prednisone (PN) and prednisolone metasulfobenzoate (PO-MS), which might account for clinical resistance to PO-MS, has been studied by an infusion technique. In a randomized cross-over design trial, a solution in isotonic saline of PN or PO-MS (115 mg·l−1 was infused at 5 ml·min−1 for 2 h, into a 25 cm segment of jejunum in 8 healthy fasting subjects. The intestinal content was partly collected and the flow rate at the end of the test segment was determined by using a water movement marker (PEG 4000). Plasma, intestinal and urine concentrations of PN and PO were determined by liquid chromatography. From the data on PO, the active molecule, the systemic availability of PO-MS was significantly smaller than of PN, with the respective mean AUCs being 1.71 and 3.60 mg·h−1. The difference was associated with smaller mean Cmax, 0.20 vs 0.64 mg·l−1, higher mean tmax, 2.94 vs 2.06 h and lower mean ka, 0.98 vs 2.18 l/h after PO-MS. No significant difference was found in the half-life or renal clearance of the formulations tested. The mean MRT was significantly increased after PO-MS, 6.82 vs 5.30 h. The observed difference probably reflected a difference in intestinal absorption. The mean absorption in the test segment of PO-MS was significantly smaller at 17.4 vs 85.5% for PN. The ester form may be a limiting factor in the intestinal absorption of PO. Therefore, the choice of PN or PO-MS should follow the therapeutic indication, depending on whether a major systemic effect or a prolonged intestinal local effect is preferred.
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  • 4
    ISSN: 1573-5028
    Keywords: rice ; Oryza sativa ; low-molecular-weight heat-shock proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5036
    Keywords: anaerobic soil ; flooded soils ; intensive cropping ; long term experiments ; lowland rice ; nitrogen mineralization ; nitrogen uptake ; on-farm research ; organic carbon ; organic matter ; Oryza sativa ; plant nitrogen ; soil nitrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Soil organic matter (SOM) has been proposed as an index of N supply in paddy soils although field validations are few. We evaluated the relationship between the indigenous N supply (N i ) of the soil-floodwater system and soil organic carbon (SOC) or total N (N t ) in surface soil of long-term fertility experiments (LTFEs) at 11 sites, in 42 farmer's fiels with similar soil type, and in the same field in ten consecutive rice (Oryza sativa L.) crops. The N i was estimated by crop N uptake from plots without applied N (N o plots) under otherwise favorable growth conditions. There was a tight linear correlation between yields and N uptake in N o plots and tremendous variation in both parameters among LTFE sites, farmer's fields, and in the same field over time. Correlation between N i and SOC or N t explained little of this variation. Factors likely to contribute to the poor correlation were: (1) inputs of N from sources other than N mineralization of SOM in surface soil, (2) degree of congruence between soil N supply and crop demand, which is sensitive to soil drying, length of fallow, crop rotation, and residue management, and (3) differences in SOM quality related to intensive cropping in submerged soil. Better understanding of the processes governing the N i of tropical lowland rice systems would contribute to the development of crop management practices that optimize utilization of indigenous N resources.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 59 (1991), S. 87-92 
    ISSN: 1570-7458
    Keywords: Sogatella furcifera ; Oryza sativa ; host plant preference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Preference studies of the white-backed planthopper, Sogatella furcifera (Horvath) (Delphacidae: Homoptera) (WBPH) for different growth stages of rice, Oryza sativa L., indicated that WBPH selected its preferred variety for feeding by alighting on the plant and feeding briefly, ‘tasting’ the plant. Differential preference for shelter, food or oviposition by WBPH were observed for different rice varieties and for different stages of a variety. With the advancement of plant age, rice varieties became more unsuitable for feeding and a process progressing more rapidly in resistant varieties. Most of the resistant varieties viz. Pundia, Landi Sarakanti and Ptb-33, unsuitable for shelter and feeding were usually not preferred for oviposition. However, the tolerant variety Mahia bankoi, though suitable for shelter and feeding was also not preferred for oviposition. Therefore, when screening varieties by only measuring feeding preference sources having tolerance mechanisms of resistance may be overlooked.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 35 (1988), S. 21-24 
    ISSN: 1432-1041
    Keywords: doxazosin ; hypertension ; alpha-adrenergic blockade ; bioavailability ; pharmacokinetics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive effects and steady-state pharmacokinetics of doxazosin, as well as the bioequivalence of four dosage forms, were studied in 25 hypertensive patients. For an 8 mg daily dose mean Cmax at steady-state for all patients was 108 ng/ml; the mean tmax was 1.8 h. The mean terminal elimination half-life was 22 h. The four tablets containing 1, 2, 4, or 8 mg of doxazosin were bioequivalent in delivering the 8 mg dose. In patients with mild to moderate hypertension, 26-day treatment with doxazosin resulted in blood pressure reduction of 10/7 mm Hg in the supine and 13/18 mm Hg in the standing position. Adverse effects were generally mild and of brief duration.
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  • 8
    ISSN: 1432-1041
    Keywords: Cefoxitin ; lidocaine ; intramuscular ; bioavailability ; pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The use of lidocaine HCl solution at concentrations of 0.5 and 1.0% to reconstitute sodium cefoxitin relieves the pain associated with intramuscular injections of the antibiotic. Cefoxitin absorption by the intramuscular route is initially rapid and is virtually complete. Peak serum concentrations, corresponding to about one-half those of a comparable intravenous infusion, are achieved in 30 min. Continuing absorption tends to maintain higher serum concentrations for longer times. Renal clearance and serum half-life of cefoxitin do not appear to be affected by lidocaine at its effective anaesthetic concentrations.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 105-110 
    ISSN: 1432-1041
    Keywords: phenytoin ; epileptic women ; pharmacokinetics ; bioavailability ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration — time data were analysed by three different pharmacokinetic techniques. However assessed, the mean oral bioavailability of the drug proved to be about 90% of the intravenous bioavailability. This finding makes it unlikely that impaired bioavailability accounts for the increase in oral phenytoin dosage necessary in pregnancy to maintain plasma phenytoin concentrations at pre-pregnancy values. Phenytoin clearance in the pregnant subjects was approximately double the published values for phenytoin clearance in nonpregnant persons. This suggests that increased (metabolic) clearance accounts for the increased phenytoin dosage requirement of pregnancy.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 105-110 
    ISSN: 1432-1041
    Keywords: phenytoin ; epileptic women ; pharmacokinetics ; bioavailability ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration — time data were analysed by three different pharmacokinetic techniques. However assessed, the mean oral bioavailability of the drug proved to be about 90% of the intravenous bioavailability. This finding makes it unlikely that impaired bioavailability accounts for the increase in oral phenytoin dosage necessary in pregnancy to maintain plasma phenytoin concentrations at pre-pregnancy values. Phenytoin clearance in the pregnant subjects was approximately double the published values for phenytoin clearance in nonpregnant persons. This suggests that increased (metabolic) clearance accounts for the increased phenytoin dosage requirement of pregnancy.
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