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  • 11
    Publication Date: 2014-03-27
    Description: Server-aided verification (SAV) has potential applicability in lightweight devices for improving signature verification, where the verifier possesses a computationally weak hardware. We observe that lightweight devices run all algorithms through hardware implementation with logic circuits. Existing SAV protocols indeed improve computational efficiency for lightweight devices, however, few of them take the hardware cost into consideration. The hardware implementation of SAV protocols could be still costly and expensive for lightweight devices. Currently, the most secure SAV protocols in the literature for pairing-based (G 1 x G 2 -〉 G T ) signatures can securely delegate pairing computations to the server; however, verifiers are still required to perform group operations over two completely different groups G 1 and G T , which heavily contribute to the cost of hardware implementation. In this work, we propose several collusion-resistant SAV protocols for pairing-based signatures to improve their applicability for lightweight devices. In our SAV protocols, verifiers are only required to perform group operations in G 1 . In comparison with existing SAV protocols, our protocols save the unnecessary hardware cost for implementing group operations in G T and therefore are more applicable to lightweight applications.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
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  • 12
    Publication Date: 2014-04-23
    Description: Mutation is the ultimate source of genetic variation and evolution. Mutation accumulation (MA) experiments are an alternative approach to study de novo mutation events directly. We have constructed a resource of Spontaneous Mutation Accumulation Lines (SMAL; http://cefg.uestc.edu.cn/smal ), which contains all the current publicly available MA lines identified by high-throughput sequencing. We have relocated and mapped the mutations based on the most recent genome annotations. A total of 5,608 single base mutations and 540 other mutations were obtained and are recorded in the current version of the SMAL database. The integrated data in SMAL provide detailed information that can be used in new theoretical analyses. We believe that the SMAL resource will help researchers better understand the processes of genetic variation and the incidence of disease.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
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  • 13
    Publication Date: 2016-09-05
    Description: The differences in evolutionary patterns of young protein–protein interactions (PPIs) among distinct species have long been a puzzle. However, based on our genome-wide analysis of available integrated experimental data, we confirm that young genes preferentially integrate into ancestral PPI networks, and that this manner is consistent in all of six model organisms with widely different levels of phenotypic complexity. We demonstrate that the level of restrictions placed on the evolution of biological networks declines with a decrease of phenotypic complexity. Compared with young PPI networks, new co-expression links have less evolutionary restrictions, so a young gene with a high possibility to be coexpressed other young genes relatively frequently emerges in the four simpler genomes among the six studied. However, it is not favorable for such young–young coexpression in terms of a young gene evolving into a coexpression hub, so the coexpression pattern could gradually decline. To explain this apparent contradiction, we suggest that young genes that are initially peripheral to networks are temporarily coexpressed with other young genes, driving functional evolution because of low selective pressure. However, as the expression levels of genes increase and they gradually develop a greater effect on fitness, young genes start to be coexpressed more with members of ancestral networks and less with other young genes. Our findings provide new insights into the evolution of biological networks.
    Electronic ISSN: 1759-6653
    Topics: Biology
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  • 14
    Publication Date: 2013-08-22
    Description: The observed bimodality in radio luminosity in galaxy clusters is puzzling: cosmic rays (CRs) accelerated by structure formation shocks are expected to indiscriminately produce bright radio haloes in every cluster. We investigate the possibility that CR streaming in the intracluster medium (ICM) can ‘switch off’ hadronically induced radio and gamma-ray emission. For self-confined CRs, this depends on the source of magnetohydrodynamic wave damping: if only non-linear Landau damping operates, then CRs stream on the slow Alfvénic time-scale, but if turbulent wave damping operates, super-Alfvénic streaming is possible. As turbulence increases, it promotes outward streaming more than it enables inward turbulent advection. Curiously, the CR flux is independent of f (as long as it is non-zero) and depends only on plasma parameters; this enables radio haloes with flat inferred CR profiles to turn off. We perform 1D time-dependent calculations of a radio mini-halo (Perseus) and giant radio halo (Coma) and find that both diminish in radio luminosity by an order of magnitude in several hundred Myr, given plausible estimates for the magnetic field in the outskirts of the cluster. Due to the energy dependence of CR streaming, spectral curvature develops, and radio haloes turn off more slowly at low frequencies – properties consistent with observations. Similarly, CR streaming rapidly turns off gamma-ray emission at the high energies probed by Cherenkov telescopes, but not at the low energies probed by Fermi . CR mediated wave heating of the ICM is unaffected, as it is dominated by ~GeV CRs which stream Alfvénically.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 15
    Publication Date: 2016-01-07
    Description: The BDB database ( http://immunet.cn/bdb ) is an update of the MimoDB database, which was previously described in the 2012 Nucleic Acids Research Database issue. The rebranded name BDB is short for Biopanning Data Bank, which aims to be a portal for biopanning results of the combinatorial peptide library. Last updated in July 2015, BDB contains 2904 sets of biopanning data collected from 1322 peer-reviewed papers. It contains 25 786 peptide sequences, 1704 targets, 492 known templates, 447 peptide libraries and 310 crystal structures of target-template or target-peptide complexes. All data stored in BDB were revisited, and information on peptide affinity, measurement method and procedures was added for 2298 peptides from 411 sets of biopanning data from 246 published papers. In addition, a more professional and user-friendly web interface was implemented, a more detailed help system was designed, and a new on-the-fly data visualization tool and a series of tools for data analysis were integrated. With these new data and tools made available, we expect that the BDB database would become a major resource for scholars using phage display, with improved utility for biopanning and related scientific communities.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 16
    Publication Date: 2016-12-04
    Description: Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain–Barré syndrome. Its NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during viral replication. Our structural analysis revealed a pre-activation state of NS3 helicase in complex with GTPS, in which the triphosphate adopts a compact conformation in the absence of any divalent metal ions. In contrast, in the presence of a divalent cation, GTPS adopts an extended conformation, and the Walker A motif undergoes substantial conformational changes. Both features contribute to more extensive interactions between the GTPS and the enzyme. Thus, this study provides structural evidence on the allosteric modulation of MgNTP 2– on the NS3 helicase activity. Furthermore, the compact conformation of inhibitory NTP identified in this study provides precise information for the rational drug design of small molecule inhibitors for the treatment of ZIKV infection.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 17
    Publication Date: 2018-03-06
    Description: A revocable ID-based broadcast encryption scheme allows an authorized third party to revoke any receiver (decryptor) from the initial receiver set S of the original broadcast ciphertext without the need of decryption. However, the existing revocable ID-based broadcast encryption schemes in the literature cannot fully preserve the receiver privacy and have a large size of ciphertext when the revoked user sets are large. To solve these problems, in this paper, we propose a novel scheme: fully privacy-preserving ID-based broadcast encryption with authorization. Our scheme allows an authorized party to dynamically handle the decryption rights of receivers via an authorized user set L without knowing the message and the identities of the initial receivers. Only those users who are both in S and L can decrypt the ciphertext successfully. The final ciphertext reveals nothing about the identity information of receivers and the authorized users. Our scheme achieves full collusion resistance and is applicable to anonymous data sharing where the receivers are decided by the authorized third party (or multiple authorized third parties) excluding the data owner. We show that our proposed scheme is provably secure under the defined security models in the random oracle model.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
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  • 18
    Publication Date: 2018-03-06
    Description: The immune status of tumor microenvironment in gastric cancer is poorly understood, which limits the development of novel strategies in this field. Sphingosine-1-phosphate (S1P) acts as an immune modulator, but the role of S1P in gastric cancer is elusive. Here, we aim to investigate S1P receptor 1 (S1P1)-mediated effect of S1P in gastric cancer. We generated a xenograft mouse model and used SEW-2871, a S1P1 specific agonist to activate S1P1 signalling. Tumor-infiltrating lymphocytes (TILs) were isolated and analysed using flow cytometry. Chemokine expression of tumor cells was evaluated using quantitative real-time polymerase chain reaction. Myeloid-derived suppressor cells (MDSCs) migration was assessed using Transwell chambers. SEW-2871 promoted tumor growth in our mouse model, and induced a higher level of MDSC and a reduced level of CD8 + CD69 + T cells within tumor. Consistently, the anti-tumoral function of cytotoxic T lymphocytes was impaired in mice with SEW-2871 treatment. Additionally, SEW-2871 enhanced expression of several MDSC recruitment-associated chemokines (CXCL12, CXCL5 and CCL2) in tumor cells. These chemokines facilitated MDSC migration by interaction with CCR2, CXCR2 and CXCR4. S1P1 signalling promoted gastric cancer by enhancing chemokine expression in tumor cells and recruiting MDSC to tumor microenvironment, which impaired anti-tumoral function of TILs.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
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  • 19
    Publication Date: 2013-01-30
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
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  • 20
    Publication Date: 2020-07-22
    Description: Summary We consider testing marginal independence versus conditional independence in a trivariate Gaussian setting. The two models are nonnested, and their intersection is a union of two marginal independences. We consider two sequences of such models, one from each type of independence, that are closest to each other in the Kullback–Leibler sense as they approach the intersection. They become indistinguishable if the signal strength, as measured by the product of two correlation parameters, decreases faster than the standard parametric rate. Under local alternatives at such a rate, we show that the asymptotic distribution of the likelihood ratio depends on where and how the local alternatives approach the intersection. To deal with this nonuniformity, we study a class of envelope distributions by taking pointwise suprema over asymptotic cumulative distribution functions. We show that these envelope distributions are well behaved and lead to model selection procedures with rate-free uniform error guarantees and near-optimal power. To control the error even when the two models are indistinguishable, rather than insist on a dichotomous choice, the proposed procedure will choose either or both models.
    Print ISSN: 0006-3444
    Electronic ISSN: 1464-3510
    Topics: Biology , Mathematics , Medicine
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