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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 12 (1996), S. 144-154 
    ISSN: 1435-5663
    Keywords: Automatic mesh generation ; Mesh control ; Mapped meshing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract This paper presents generated enhancements for robust ‘two and three-quarter dimensional meshing’, including: (1) automated interval assignment by integer programming for submapped surfaces and volumes, (2) surface submapping, and (3) volume submapping. An introduction to the simplex method, an optimization technique of integer programming, is presented. Simplification of complex geometry is required for the formulation of the integer programming problem. A method of ‘i-j unfolding’ is defined which explains how irregular geometry can be realigned into a simplified form that is suitable for submap interval assignment solutions. Also presented is the processes by which submapping eliminates the decomposition of surface geometry, through a pseudodecomposition process, producing suitable mapped meshes. The process of submapping involves the creation of ‘interpolated virtual edges’, user defined ‘vertex types’ and ‘i-j-k space’ traversals. The creation of ‘interpolated virtual edges’ is the method by which submapping automatically subdivides surface geometry. The ‘interpolated virtual edge’ is formulated according to an interpolation scheme using the node discretization of curves on the surface. User defined ‘vertex types’ allow direct user control of surface decomposition and interval assignment by modifying ‘i-j-k space’ traversals. Volume submapping takes the geometry decomposition to a higher level by using ‘mapped virtual surfaces’ to eliminate decomposition of complex volumes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 19 (1990), S. 190-196 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Twelve workers were monitored for exposure to 18.75% lindane dust formulation during manual wheat seed treatment. The mean total actual exposure rate was 32.89 mg/hr. Potential respiratory exposure averaged 0.0057 mg/hr (〈1% of the total), with seven workers receiving no measurable respiratory exposures. Mean hand exposure was 1.84 mg/hr (5.6%). Dermal exposure to the head and neck averaged 4.28 mg/hr (13%). Exposure measured beneath the workshirt and workpants averaged 26.8 mg/hr (81.4%). The workshirt and workpants provided 3.4-fold and 11.5-fold protection factors, respectively. Forearm exposure measured beneath the workshirt represented more than 40% of total actual exposure. The small contribution of hand exposure to total dermal exposure was consistent with the use of chemical-resistant gloves by all workers. Total dermal exposure could be reduced substantially by wearing coveralls over regular work clothing, and by the use of gauntlet-type gloves. It is recommended that worker education concerning personal hygiene and the appropriate use of protection clothing be made essential components of exposure reduction programs.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1617-4623
    Keywords: Key words Adenine phosphoribosyl transferase ; Cytokinins ; Arabidopsis thaliana ; Mutant ; Male sterility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Four mutants of Arabidopsis thaliana that are deficient in adenine phosphoribosyl transferase (APRT) activity have been isolated by selecting for germination of seeds and growth of the plantlets on a medium containing 2,6-diaminopurine (DAP), a toxic analog of adenine. In all mutants, DAP resistance is due to a recessive nuclear mutation at a locus designated apt. The mutants are male sterile due to pollen abortion after meiosis. Furthermore, it has been shown that metabolism of cytokinins is impaired in the mutant BM3, which has the lowest level of APRT activity among the mutants tested. However, three different cDNAs encoding APRT have been isolated in A. thaliana and this raised the question of the nature of the mutation which results in low APRT activity. The mutation was genetically mapped to chromosome I and lies within 6 cM of the phenotypic marker dis2, indicating that the mutation affects the APT1 gene, a result confirmed by sequencing of mutant alleles. The mutation in the allele apt1-3 is located at the 5′ splicing site of the third intron, and eliminates a BstNI restriction site, as verified by Southern blotting and PCR fragment length analysis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 12 (1996), S. 143-143 
    ISSN: 1435-5663
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 13 (1997), S. 35-47 
    ISSN: 1435-5663
    Keywords: Hexahedral mesh generation ; Mesh refinement ; Plastering ; Whisker Weaving
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract The spatial twist continuum (STC) is a powerful extension of the dual of a hexahedral mesh Murdochet al.,Int. J. Numer. Math. Engng (submitted). The STC captures the global connectivity constraints inherent in hexahedral meshing. Whisker wwaving is an advancing-front type of algorithm based on the STC[Tautges et al., Int. J. Numer. Math. Engng (submitted]. During the whisker weaving algorithm, certain types of degenerate elements calledwedges [Biacker; Myers (1993)Engng with Computers 9, 83–93 arise. This paper describedwedges and how they are formed, and presentscollapsing anddriving, two strategies for removing these degeneracies.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Engineering with computers 9 (1993), S. 83-93 
    ISSN: 1435-5663
    Keywords: Mesh generation ; Plastering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Notes: Abstract This paper describes mesh correction techniques necessary for meshing an arbitrary volume with a completely hexahedral mesh. Specifically, it describes seams and wedges, mechanisms that overcome major hurdles encountered in the preliminary work on the plastering algorithm. The plastering algorithm iteratively projects layers of elements inward from a quadrilateral discretization of the volume's bounding faces. Seams and wedges resolve incompatibilities in the mesh and in the progressing boundary, thus ensuring the correct formation of a hexahedral mesh from the plastering algorithm.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2013-11-08
    Description: Background: The advent of genome-wide association studies has led to many novel disease-SNP associations, opening the door to focused study on their biological underpinnings. Because of the importance of analyzing these associations, numerous statistical methods have been devoted to them. However, fewer methods have attempted to associate entire genes or genomic regions with outcomes, which is potentially more useful knowledge from a biological perspective and those methods currently implemented are often permutation-based. Results: One property of some permutation-based tests is that their power varies as a function of whether significant markers are in regions of linkage disequilibrium (LD) or not, which we show from a theoretical perspective. We therefore develop two methods for quantifying the degree of association between a genomic region and outcome, both of whose power does not vary as a function of LD structure. One method uses dimension reduction to ''filter'' redundant information when significant LD exists in the region, while the other, called the summary-statistic test, controls for LD by scaling marker Z-statistics using knowledge of the correlation matrix of markers. An advantage of this latter test is that it does not require the original data, but only their Z-statistics from univariate regressions and an estimate of the correlation structure of markers, and we show how to modify the test to protect the type 1 error rate when the correlation structure of markers is misspecified. We apply these methods to sequence data of oral cleft and compare our results to previously proposed gene tests, in particular permutation-based ones. We evaluate the versatility of the modification of the summary-statistic test since the specification of correlation structure between markers can be inaccurate. Conclusion: We find a significant association in the sequence data between the 8q24 region and oral cleft using our dimension reduction approach and a borderline significant association using the summary-statistic based approach. We also implement the summary-statistic test using Z-statistics from an already-published GWAS of Chronic Obstructive Pulmonary Disorder (COPD) and correlation structure obtained from HapMap. We experiment with the modification of this test because the correlation structure is assumed imperfectly known.
    Electronic ISSN: 1471-2156
    Topics: Biology
    Published by BioMed Central
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  • 8
    Publication Date: 1990-03-01
    Print ISSN: 0090-4341
    Electronic ISSN: 1432-0703
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Springer
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  • 9
    Publication Date: 2001-10-01
    Print ISSN: 0177-0667
    Electronic ISSN: 1435-5663
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Published by Springer
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  • 10
    Publication Date: 1993-06-01
    Print ISSN: 0177-0667
    Electronic ISSN: 1435-5663
    Topics: Computer Science , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Published by Springer
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