ISSN:
1432-1041
Keywords:
atrial natriuretic factor (ANF)
;
lithium
;
renal sodium handling
;
renal haemodynamics
;
infusion
;
injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In 7 healthy humans consuming a 170 mmol sodium diet the effect of the mode of administration of atrial natriuretic factor (human ANF 99–126) on renal function has been investigated, using conventional clearance studies during maximal water diuresis. ANF was administered as four repeated bolus (0.4 µg/kg) injections and, after a 2-day interval, as a one-hour infusion (0.02 µg/kg/min) preceded by a 0.4 µg/kg bolus injection. In the two experiments ANF caused comparable elevations in glomerular filtration rate, free water clearance, and lithium excretion. No change in blood pressure or heart rate was observed in either study, and plasma renin activity and aldosterone fell by a similar extent. As expected, the time course of plasma ANF concentrations was markedly different during the two studies. It is concluded that with those doses of ANF the changes in renal haemodynamics and sodium handling were essentially similar after bolus injections and a constant infusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609194
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