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  • Articles  (89)
  • Springer  (57)
  • Springer Nature  (27)
  • Institute of Physics  (5)
  • Berlin: Deutsches Institut für Wirtschaftsforschung (DIW)
  • Medicine  (89)
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  • Articles  (89)
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  • 1
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    Soluble polysialylated NCAM: a novel player of the innate immune system in the lung (2013)
    Springer
    Details
    Publication Date: 2013-04-26
    Print ISSN: 1420-682X
    Electronic ISSN: 1420-9071
    Topics: Biology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Studies on the ascorbic acid metabolism of callitrichid monkeys by14C isotope excretion technique (1990)
    Springer
    European journal of nutrition 29 (1990), S. 192-196 
    Details
    ISSN: 1436-6215
    Keywords: Ascorbic acid metabolism ; Callitrichidae ; stress ; 14CO2-excretion ; Ascorbinsäurestoffwechsel ; Krallenaffen ; Streß ; 14CO2-Ausscheidung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Bei den beiden Affenarten Callithrix jacchus und Saguinus fuscicollis, die der gleichen Neuweltaffenfamilie der Krallenaffen angehören, wurden extrem unterschiedliche Serumascorbatspiegel gefunden, obwohl die Tiere unter identischen Bedingungen in derselben Kolonie gehalten wurden. Die14C-Ausscheidung von oral verabreichter 1-14C-AA wurde unter marginaler wie auch reichlicher Vitamin-C-Versorgung sowie unter Streßbedingungen untersucht. Zwischen niedriger und hoher Vitamin-C-Versorgung traten große Unterschiede im14C-Ausscheidungsmodus auf. Der Speziesunterschied war dabei geringer als der Unterschied zwischen individuellen Streß-/Nichtstreß-Bedingungen, aber in beiden Fällen war er gleichartig. In vergleichbaren Versuchen reagierte S. fuscicollis derart, daß ein höherer Streßzustand bei dieser Spezies angenommen werden kann.
    Notes: Summary Recently it has been found that the two monkey species Callithrix jacchus and Saguinus fuscicollis, both belonging to the same New World monkey family Callitrichidae and held in the same colony under identical conditions, had extremely different serum ascorbate levels. To examine the ascorbic acid metabolism the14C-excretion of orally given 1-14C-ascorbic acid was studied under conditions of marginal and abundant vitamin C supply and under intentional stress. There were large differences in the mode of14C excretion between low and high ascorbate supply. The differences were smaller between stress/no stress conditions intraindividually than between the two species, but they were in the same manner. In comparable trials S. fuscicollis reacted such that a higher status of stress can be supposed in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021558
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  • 3
    Electronic Resource
    Electronic Resource
    Endolymphatic leakage in case of acute loss of cochlear microphonics (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 363-364 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rapid loss of cochlear microphonics in guinea-pigs previously exposed to high-energy impulse noise was shown to be related to the breakdown of the endolymphatic boundary. The cochlear duct was rendered leaky by deterioration of the reticular membrane, and damage of sensory and supporting cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923037
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  • 4
    Electronic Resource
    Electronic Resource
    Electron microscopic demonstration of a particulate component in the glycocalyx (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 770-771 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung An der Oberfläche isolierter Glomerulus-Basalmembranen des Schweins konnten durch Gefrierätzung und durch Negativkontrastierung unregelmässig verteilte Partikel nachgewiesen werden. Sie werden als Reste der Glycocalyx von Endothel- beziehungsweise Epithelzellen angesehen und zeigen einen partikulären Aufbau dieser Kohlenhydratschicht an.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02232540
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  • 5
    Electronic Resource
    Electronic Resource
    Beiträge zur Atmung der Fische. III (1939)
    Springer
    Journal of comparative physiology 27 (1939), S. 429-433 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340706
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  • 6
    Electronic Resource
    Electronic Resource
    Beiträge zur Atmung der Fische. IV (1939)
    Springer
    Journal of comparative physiology 27 (1939), S. 443-444 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340708
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  • 7
    Electronic Resource
    Electronic Resource
    Pulmonary aspergillus intracavitary colonization (PAIC) (1990)
    Springer
    Mycopathologia 112 (1990), S. 93-104 
    Details
    ISSN: 1573-0832
    Keywords: Aspergillus ; fungal elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have attempted to elucidate the natural history of pulmonary aspergillus intracavitary colonization (PAIC) based on more than 350 cases of the disease observed in the last 11 years and on data collected from the literature. The data indicate that PAIC is a dynamic process consequent to the continual growth and death of fungal elements and also with their relationships to the anatomic features of the cavity (valvular mechanisms, vascular alteration). The clinical presentations reflect immunological changes in the host. Metabolites produced by the species of Aspergillus involved affect the clinical presentation of the syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436504
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  • 8
    Electronic Resource
    Electronic Resource
    Acute pulmonary paracoccidioidomycosis in an immunosuppressed patient (1979)
    Springer
    Mycopathologia 68 (1979), S. 171-174 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A case of an acute pulmonary paracoccidioidomycosis following the use of immunosuppressive therapy in a solid cancer patient is reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578525
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  • 9
    Electronic Resource
    Electronic Resource
    Cytological investigations on the T-locus in Mus musculus L. (1964)
    Springer
    Chromosoma 15 (1964), S. 478-502 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The extensive genetical analysis of the T-locus in mice, carried out by Dunn and his co-workers, has revealed that the breeding pattern of t-alleles is very peculiar. The complexity of the T-locus indicates that some structural rearrangements are involved here. The purpose of the present work was to gain some informations on the structure of chromosomes in which t-alleles are present. 2. The course of spermatogenesis in the lines of mice of the following genotypes was investigated: +/+; T/+; T/t n — namely T/t 0, T/t12, T/tw1, T/tw6, T/tw18; tn/tx — namely t 0/t12, t0/tw18, t12/tw18, tw1/t12, tw1/t0, tw1/tw6, tw1/tw18, and in heterozygotes for translocations T138 and T190, both involving the fragment of linkage group IX in which some t-alleles are present and used as markers. 3. The alleles T and t w1 are not connected with structural rearrangements, as far as detectable by the methods used. The alleles t 0, tw6 and t w18 are interstitial deficiencies involving different chromosomal regions. The most complete data were obtained for t 0: in T/t 0 heterozygotes a loop corresponding to a big interstitial deficiency was present, in all t 0/tn compounds the aberrant structure of one of the bivalents indicated that an interstitial deficiency is here involved. By analysis of translocation T190 the deficiency loop is localized in the chromosome representing linkage group IX. The identification of t w6 as a small interstitial deficiency is based on the analysis of T/t w6 heterozygotes and its localization in linkage group IX on the presence of this deficiency in translocation T138. The description of tw18 as a small interstitial deficiency stems from the analysis of T/tw18 and t 0/tw18, the localization in linkage group IX is shown by its presence in t 0/tw18 in the same bivalent as t 0. The evidence obtained for t 12 indicates that it is either a big terminal deficiency or a small interstitial one inducing constant asynapsis in adjacent terminal segments of the bivalent. 4. The reasons why loops encountered in genotypes involving t 0, tw6 and t w18 are considered as deficiencies and not as duplications are based on available embryological and genetical data. The possible connections between the mode of action of the investigated t-alleles as embryonic lethals and the cytological results on their structure and localization are discussed. 5. Most of the lethal t-alleles suppress crossing-over in the region T-tf. Factors reducing the frequency of recombination in other organisms are discussed in comparison. It is concluded that the pattern of aberation in meiotic behavior of the bivalent carrying t-alleles is for almost each of the studied alleles rather specific and does not permit for suggesting any general mechanism which could account for the action of investigated lethal t-alleles as crossing-over suppressors. 6. A diagram of the presumable localisation of genetical factors in linkage group IX is presented. It is concluded that the so-called T-locus occupies the main part of the long arm of the chromosome corresponding to linkage group IX and that the investigated t-alleles are not unilocal neither with the gene T nor each with other, but scattered along the chromosome. 7. The possible modes of the origin of new t-alleles are discussed, and the hypothesis is advanced that this event might be connected with mistakes of replication of the strand on which a new t-allele arises.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368143
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  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen über die anisotrope Toluidinblaufärbung der Glykokalyx (1977)
    Springer
    Histochemistry and cell biology 50 (1977), S. 261-270 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An der Erythrocytenmembran wird die Beziehung zwischen anisotroper Toluidinblaufärbung und Membranstruktur untersucht. Enzymatischer oder chemischer Abbau der Glykokalyx stört die topo-optische Färbung. Eine Abschwächung wird auch durch Digitoninbehandlung Glutaraldehyd-fixierter Zellen erzielt. Durch Chloroform-Methanol-Inkubation wird die anisotrope Toluidinblaufärbung gelöscht, aber sie kann nach Aldehyd-Bisulfitbildung wieder nachgewiesen werden. An agglutinierten Erythrocyten ist die Wirkung einer Chloroform-Methanol-Behandlung stark eingeschränkt. Die reversibel kollabierte Glykokalyx zeigt keine topo-optische Färbung. Die Befunde werden als Hinweis auf die Bedeutung der räumlichen Orientierung der Glykoproteine an der Zelloberfläche gedeutet. Störungen im Aufbau der Glykokalyx durch Hydrolyse bzw. Verlust oder durch Umverteilung von Komponenten verändern die Bedingungen für die anisotrope Toluidinblaufärbung. Eingriffe an der Lipidschicht können mit solchen Veränderungen einhergehen; für die Interkalation von Farbstoffmolekülen in die Lipidschicht ergab sich jedoch kein Anhalt. Die topo-optische Färbung mit Toluidinblau wird auf Grund dieser Ergebnisse als geeignetes Verfahren zur Untersuchung der Glykokalyx von Erythrocyten (und vermutlich auch anderer Zellen) angesehen.
    Notes: Summary The study was concerned with the molecular structure of the erythrocyte membrane and its anisotropic staining with toluidine blue. Enzymatic or chemical degradation impairs the topo-optical staining. Decreased anisotropy results also from digitonin treatment of glutaraldehyde fixed cells. Incubation in a mixture of chloroform and methanol abolishes the anisotropic staining with toluidine blue, but it has been restored by the aldehyde bisulfite-procedure. The efficacy of a treatment with chloroform-methanol is greatly reduced in the case of agglutinated erythrocytes. The reversibly collapsed glycocalyx is devoid of topo-optical staining. The findings refer to the spatial orientation of glycoproteins at the cell surface. Degradation or loss and rearrangement, respectively, change the glycocalyx structure and likewise deteriorate the conditions for the anisotropic staining. Alterations of the lipid layer of the membrane may result in similar effects. There was, however, no indication of an intercalation into the lipid layer of dyestuff molecules. In conclusion, the topo-optical toluidine blue staining is considered a powerful method aiding studies of the glycocalyx of erythrocytes (and presumably of other types of cells too).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491073
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