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Predictive usefulness of RT-PCR testing in different patterns of Covid-19 symptomatology: analysis of a French cohort of 12,810 outpatients (2021)

, ; Apra, Caroline ; Caucheteux, Charlotte ; [weitere]

Springer Nature

In: Scientific Reports. 2021; 11(1): 21233. Published 2021 Oct 27. doi: 10.1038/s41598-021-99991-6.

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Publikationsdatum: 2021-10-27

Beschreibung: Reverse transcriptase polymerase chain reaction (RT-PCR) is a key tool to diagnose Covid-19. Yet it may not be the most efficient test in all patients. In this paper, we develop a clinical strategy for prescribing RT-PCR to patients based on data from COVIDOM, a French cohort of 54,000 patients with clinically suspected Covid-19, including 12,810 patients tested by RT-PCR. We use a machine-learning algorithm (decision tree) in order to predict RT-PCR results based on the clinical presentation. We show that symptoms alone are sufficient to predict RT-PCR outcome with a mean average precision of 86%. We identify combinations of symptoms that are predictive of RT-PCR positivity (90% for anosmia/ageusia) or negativity (only 30% of RT-PCR+ for a subgroup with cardiopulmonary symptoms): in both cases, RT-PCR provides little added diagnostic value. We propose a prescribing strategy based on clinical presentation that can improve the global efficiency of RT-PCR testing.

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Digitale Medien

Thin film mixtures synthesized by cross-beam PLD (1999)

Gorbunov, A.A. ; Tselev, A.E. ; Elefant, D. ; [weitere]

Springer

Applied physics 69 (1999), S. S463

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ISSN: 1432-0630

Schlagwort(e): PACS: 81.15.Fg; 64.60.My; 61.66.Dk

Quelle: Springer Online Journal Archives 1860-2000

Thema: Maschinenbau , Physik

Notizen: Abstract. Fabrication of metastable binary solid state film mixtures with continuously variable composition by asymmetric cross-beam PLD is demonstrated. In this technique, the materials are mixed directly in the intersection region of colliding plasmas of individual target materials. This technique can be advantageous for synthesis of solid state quasi-solutions of partially miscible materials, where one can expect interesting mechanic properties and magnetic transformations.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s003390051439

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Investigation of surface topography, morphology and structure of amorphous carbon films by AFM and TEM (1995)

Scheibe, H.-J. ; Drescher, D. ; Kolitsch, A. ; [weitere]

Springer

Fresenius' Zeitschrift für analytische Chemie 353 (1995), S. 690-694

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ISSN: 1618-2650

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract Morphology and structure of amorphous carbon films deposited with a pulsed arc source (LASER-ARC) have been studied using microscopical methods (SEM, TEM and AFM), electron diffraction and spectroscopical investigation (EELS). The parameters of the arc source and the deposition conditions (substrate temperature) influence morphology and structure of deposited amorphous carbon films. Especially the incorporation and growth of particles, embedded in the film have been investigated. By particle analysis using an optical microscope a majority of particles that is smaller than 500 nm has been determined. The morphology has been also demonstrated similar by AFM and TEM images. Their number and size of particles is strongly influenced by the deposition temperature. The structure of amorphous film is characterized by the EELS-spectra, but the particle structure was not detectable.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00321351

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A macroeconomic potential describing structural change of the economy (1985)

Haag, Günter ; Weidlich, Wolfgang ; Mensch, Gerhard O.

Springer

Theory and decision 19 (1985), S. 279-299

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ISSN: 1573-7187

Quelle: Springer Online Journal Archives 1860-2000

Thema: Sociologie , Wirtschaftswissenschaften

Notizen: Abstract For the purpose of describing change in an economy's structure, and addressing issues of transformation, the notion of a time-dependent macroeconomic potential function is introduced. It penalizes deviations from equilibrium (entrepreneurial error) and induces moves toward equilibrium. Thus, from the concept of a potential function is derived the concept of short-term and long-term change forces. We focus here on the long-term structural changes of an economy as distinct from short-term cyclical variations, and we represent economic transformations as phase-transitions between monostable and ambiguous bistable states of the economy. One important feature of the potential function approach is that the parameter of the potential can be determined from empirical data. In particular, the parameters can be regressed for input variables. Hence, a relationship has been established between the structural change force and a set of input variables, some of which are controlled in part by either public or private sector agents. The method has been applied to West German and United States industry data for 1950–1980.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00126418

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Longitudinal electric response and loss-function of metallic microspheres and voids (1995)

Baltz, R. ; Mensch, M. ; Zohm, H.

Springer

The European physical journal 98 (1995), S. 151-161

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ISSN: 1434-6036

Schlagwort(e): 71.45Gm ; 73.20Mf ; 79.20Kz

Quelle: Springer Online Journal Archives 1860-2000

Thema: Physik

Notizen: Abstract The response of a spherical metallic particle and a void in a metal on an arbitrary external electrical (gradient) field is given analytically within two models: a macroscopic dielectric description in terms of dielectric functions and a linearized hydrodynamic theory which takes into account boundary effects as well as spatial dispersion. From the response functions, the eigenfrequencies of the collective modes and the electron-energy-loss function are obtained. For small radii we found collective modes extending beyond the classical ℓ = ∞ limit of surface-plasmons up to the volume-plasmon. Concerning electron-energy-losses, our results demonstrate that the “blue-shift” on the collective modes which were observed in potassium clusters or calculated for voids in metals are almost of classical origin and stem from spatial dispersion.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01324520

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6

Digitale Medien

Rank restrictions on the quadratic form in indefinite quadratic programming (1971)

Amato, H. ; Mensch, G.

Springer

Mathematical methods of operations research 15 (1971), S. 214-216

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ISSN: 1432-5217

Quelle: Springer Online Journal Archives 1860-2000

Thema: Mathematik , Wirtschaftswissenschaften

Beschreibung / Inhaltsverzeichnis: Zusammenfassung Ein quadratisches Optimierungsproblem, in demq(x) =a T x +x T Qx eine indefinite Zielfunktion ist, kann mitSwarups Optimierungsansatz (c T x + α)(d T x + β) nur gelöst werden, wenn der Rang vonQ gleich zwei ist; wennQ definit ist, muß der Rang vonQ gleich eins sein.

Notizen: Summary A quadratic programming problem, whereq(x) =a T x +x T Qx is an indefinite objective function, can be solved withSwarup's approach of optimizing (c T x + α)(d T x + β) only if the rank ofQ is two; ifQ is definite, the rank ofQ must be one.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01939829

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Temperature mapping of operating nanoscale devices by scanning probe thermometry (2016)

Fabian Menges; Philipp Mensch; Heinz Schmid; Heike Riel; Andreas Stemmer; Bernd Gotsmann

Springer Nature

In: Nature Communications

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Publikationsdatum: 2016-03-05

Beschreibung: Article Thermometry using scanning probe techniques allows for the thermal imaging and characterization of devices with nanoscale resolution, however can be hindered by contact-related artefacts. Here, the authors demonstrate a thermal scanning probe approach which eliminates contact-resistance effects. Nature Communications doi: 10.1038/ncomms10874 Authors: Fabian Menges, Philipp Mensch, Heinz Schmid, Heike Riel, Andreas Stemmer, Bernd Gotsmann

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen (2016)

Hans Sterckx, Johan De Houwer, Carl Mensch, Wouter Herrebout, Kourosch Abbaspour Tehrani and Bert U. W. Maes

Beilstein-Institut

In: Beilstein Journal of Organic Chemistry

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Publikationsdatum: 2016-01-28

Beschreibung: The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP–MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit. Beilstein J. Org. Chem. 2016, 12, 144–153. doi:10.3762/bjoc.12.16

Schlagwort(e): base metalbenzyliccatalyzedmolecular oxygenoxygenation

Digitale ISSN: 1860-5397

Thema: Chemie und Pharmazie

Publiziert von Beilstein-Institut

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