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  • Springer Nature  (14)
  • Springer  (11)
  • Geological Society of America (GSA)  (2)
  • American Institute of Physics (AIP)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 1195-1197 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Recent theoretical studies have concluded that the low formation enthalpies of intrinsic donor defects should preclude achievement of p-type conductivity in undoped ZnO grown in thermal equilibrium with a molecular oxygen reservoir. This letter demonstrates that reactive sputtering can produce intrinsic p-type ZnO, controlled by adjusting the oxygen partial pressure in the sputtering plasma. We report the properties of p–n homojunctions fabricated in this way, and characterize transport in the films by Hall measurements. Our finding of p-type conductivity in undoped ZnO grown with dissociated oxygen is qualitatively consistent with the effect of higher chemical potential of atomic oxygen reactant on defect formation enthalpies. This parallels to some degree the recent attention to nitrogen acceptor incorporation by means of dissociating nitrogen source gases. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0649
    Keywords: 85.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 177-180 
    ISSN: 1432-1041
    Keywords: Amphetamine ; drug dependence ; metabolism ; urine ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolism of (+)-[14C] amphetamine has been studied in two women who had been taking 90–100 mg of Dexedrine ((+)amphetamine sulphate; Smith, Kline & French) daily for several years but who showed no evidence of overt amphetamine toxicity. The urinary metabolites were identified, estimated and compared with the results previously obtained from two drug naive male subjects who had received 20 mg of (±)amphetamine (Caldwellet al., (1972b). The same metabolites were found, but the dependent subjects excreted in 24 h more unchanged amphetamine (about 30% of dose) than the naive subjects (20%). This may be a reflection of the dose, which in dependent subjects was five times that of naive subjects. The dependent subjects excreted in 24 h slightly more norephedrine (2.9, 4.1% of dose) and 4′-hydroxynorephedrine (1.1, 1.6%) than the naive subjects (norephedrine, 2.2, 2.6%; 4′-hydroxynorephedrine, 0.3, 0.4%), but the difference in percentage of dose may not be significant. However, in absolute terms the dependent subjects are producing at least five times as much norephedrines as the naive subjects because of the larger dose.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 9 (1975), S. 193-198 
    ISSN: 1432-1041
    Keywords: (−)-[14C]-ephedrine ; metabolism ; urinary excretion ; tolerance ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolic fate of orally administered (−)-[14C]-ephedrine has been studied in 3 human subjects and the urinary excretion of metabolites determined quantitatively by solvent extraction, paper chromatography and reverse isotope dilution procedures. Following an oral dose of the drug (0.35 mg/kg, 1.6 µCi), 97% of the dose was excreted in the urine within 48 h, 88% in the first 24 h. Unchanged drug was the major urinary excretory product (53–74%), with N-demethylation occurring to a variable extent (8–20%) although there was little interindividual variation in urine pH. Oxidative deamination was also variable (4–13%); the main identified products of this were benzoic acid (free and conjugated) and 1,2-dihydroxy-1-phenylpropane (free and conjugated). No phenolic metabolites could be detected, and thus it would appear that these compounds cannot be implicated in the acquisition of tolerance to ephedrine which can occur on repeated dosage.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0878
    Keywords: Key words: TGF-β receptor type II ; Fetuin ; Brain development ; Subplate neurons ; Sheep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Fetuin shows a characteristic pattern of distribution in the developing neocortex in many mammalian species. Its expression is confined to early-appearing cortical-plate and later subplate neurons. A short 19 amino-acid sequence of fetuin shows a degree of homology to an 18 amino-acid sequence of the TGF-β type II receptor (TβR-II) and in vitro fetuin binds to members of the TGF-β family of cytokines. It has been suggested that fetuin is the biologically significant antagonist of these cytokines. We have compared, using immunocytochemistry, the distribution pattern of TβR-II and fetuin in the developing neocortex of foetal sheep. TβR-II immunoreactivity first appears at around 40 days of gestation in the fetal sheep (E40, term in sheep is 150 days from conception), localised in two discreet bands: one just outside the cortical plate in the inner part of the marginal zone and one deep in the cortical plate in what becomes the transient subplate zone. By E70–E80, TβR-II is prominent in a population of subplate cells, whereas, by E120 only small patches of TβR-II-positive cells are visible, principally in pyramidal cells in layer VI. The developmental sequence of the staining pattern for TβR-II in the neocortex is complementary to that for fetuin, rather than overlapping with it. Double-labelling of fetuin and TβR-II shows some cellular co-localisation, especially at E60, but most fetuin-positive cells are not immunoreactive for TβR-II. Thus, fetuin’s proposed role as an antagonist of TGF-β cytokines and mimic of TβR-II is not consistent with the observed distribution of these two molecules in the developing neocortex of the foetal sheep.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 120 (1940), S. 21-22 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 7
    Publication Date: 2015-07-30
    Description: We assessed tectonic controls on the spatial and temporal distribution of fault zone flow pathways in the Rio Grande rift (New Mexico, USA) by using fault zone calcite cements as a geochemical record of syntectonic fluid flow. Cement 18 O, 13 C, and 87 Sr/ 86 Sr values indicate that older, large-displacement master and basin-margin faults were cemented by more isotopically evolved basinal brines than younger intrabasin faults. These data suggest that diagenetic fluids in basin-bounding faults equilibrated predominantly with downdip Paleozoic carbonates. In contrast, intrabasin faults transmitted fluids from shallow stratigraphic sources. This pattern of flow pathways is linked to the systematic distribution of sediments and faults that record rift evolution, which dictated spatial and temporal variations in fault zone architecture and permeability structure. Our results indicate that the depths from which fluids can be transported in active rift basins ultimately depend on both tectonically mediated variations in the grain size of syntectonic sediments entrained in fault damage zones and fault displacement magnitude.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 8
    Publication Date: 1997-11-26
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 9
    Publication Date: 2017-03-01
    Description: Diagenesis demonstrably changes both the mechanical and hydrologic properties of sediments. However, the effect of these changes on the distribution and types of structures that develop in fault zones over time, and their impact on fault-zone fluid flow has not previously been systematically investigated. We explored the impact of diagenesis on the mechanical and hydrologic properties of initially unlithified sand cut by a syndepositional normal fault in an extensional basin. Field, microstructural, and geochemical data document a diagenetic record of initially continuous fluid flow through a hanging-wall damage zone up to 10 m wide. In this zone, initial deformation via particulate flow is recorded by a foliation defined by a grain shape preferred orientation, preserved by subsequently precipitated, pore-filling calcite cement. A transition to episodic fluid flow is demonstrated by calcite veins that crosscut the previously cemented, foliated sandstone within relatively narrow (≤5 m from the fault core) segments of the older damage zone. Unlike the widespread record of particulate flow, veins are restricted to the vicinity of a mapped relay zone between overlapping fault segments, and an inferred, partially covered relay zone. Vein microstructures record repeated fracture opening and sealing. Veins in breccia zones have 13 C values as high as +6.0, suggesting degassing of CO 2 - and/or CH 4 -charged fluids. These data collectively suggest that relatively early damage zone cementation strengthened and stiffened the foliated damage zone, affecting the localization of brittle fractures and fluid flow in relay zones. Our results highlight systematic changes in the character and locus of deformation and fluid flow during the development of normal faults and provide a basis for predicting how these structures may act to trap or transmit fluids during the development of extensional basins.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 10
    Publication Date: 2002-09-01
    Print ISSN: 1028-3358
    Electronic ISSN: 1562-6903
    Topics: Physics
    Published by Springer
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