ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • National Academy of Sciences  (33)
  • Nature Publishing Group (NPG)  (7)
  • American Institute of Physics  (1)
  • 1
    facet.materialart.
    Unbekannt
    Human antibodies that neutralize dengue virus [Microbiology] (2012)
    National Academy of Sciences
    Details
    Publikationsdatum: 2012-05-09
    Beschreibung: Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50 countries. Even though infected individuals develop potent and long-lasting serotype-specific neutralizing antibodies (Abs), the epitopes engaged by human neutralizing Abs have not been identified. Here, we demonstrate that the dengue virus (DENV)-specific serum Ab response in humans consists of a large fraction of cross-reactive, poorly neutralizing Abs and a small fraction of serotype-specific, potently inhibitory Abs. Although many mouse-generated, strongly neutralizing monoclonal antibodies (mAbs) recognize epitopes that are present on recombinant DENV envelope (E) proteins, unexpectedly, the majority of neutralizing Abs in human immune sera bound to intact virions but not to the ectodomain of purified soluble E proteins. These conclusions with polyclonal Abs were confirmed with newly generated human mAbs derived from DENV-immune individuals. Two of three strongly neutralizing human mAbs bound to E protein epitopes that were preserved on the virion but not on recombinant E (rE) protein. We propose that humans produce Abs that neutralize DENV infection by binding a complex, quaternary structure epitope that is expressed only when E proteins are assembled on a virus particle. Mapping studies indicate that this epitope has a footprint that spans adjacent E protein dimers and includes residues at the hinge between domains I and II of E protein. These results have significant implications for the DENV Ab and vaccine field.
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Publiziert von National Academy of Sciences
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 2
    facet.materialart.
    Unbekannt
    Aspirin-dependent cyclooxygenase acetylation [Medical Sciences] (2014)
    National Academy of Sciences
    Details
    Publikationsdatum: 2014-11-26
    Beschreibung: The cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs) may be influenced by interactions with antiplatelet doses of aspirin. We sought to quantitate precisely the propensity of commonly consumed NSAIDs—ibuprofen, naproxen, and celecoxib—to cause a drug–drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS....
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Publiziert von National Academy of Sciences
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 3
    facet.materialart.
    Unbekannt
    Palaeontology: The last giant kangaroo (2008)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2008-08-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2008 Aug 14;454(7206):835-6. doi: 10.1038/454835a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18704074" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Archaeology ; *Extinction, Biological ; Fossils ; Humans ; Macropodidae/*physiology ; Tasmania ; Time
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 4
    facet.materialart.
    Unbekannt
    Archaeology: Maya, Khmer and Inca (2009)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2009-09-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2009 Sep 24;461(7263):479-80. doi: 10.1038/461479a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779438" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/history ; Animals ; Archaeology ; Cambodia ; Central America ; Civilization/*history ; Climate ; Droughts ; Forestry/*history ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, Medieval ; Population Density ; South America ; Trees/growth & development ; Wood/history
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 5
    facet.materialart.
    Unbekannt
    Linguistics: Deep relationships between languages (2011)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2011-08-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2011 Aug 17;476(7360):291-2. doi: 10.1038/476291a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21850102" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cultural Evolution/history ; Emigration and Immigration/history ; History, Ancient ; Language/*history ; Linguistics ; North America/ethnology ; Siberia/ethnology
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 6
    facet.materialart.
    Unbekannt
    Population history: Human melting pots in Southeast Asia (2014)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2014-08-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2014 Aug 21;512(7514):262-3. doi: 10.1038/512262a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography, University of California, Los Angeles, Los Angeles, California 90095-1524, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25143110" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Emigration and Immigration ; *Gene Flow ; Humans ; *Language
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 7
    facet.materialart.
    Unbekannt
    Sociology: political evolution (2010)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2010-10-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2010 Oct 14;467(7317):798-9. doi: 10.1038/467798a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20944737" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Asia, Southeastern ; Geography ; Language ; Linguistics/methods ; Models, Theoretical ; New Zealand ; Pacific Islands ; Pacific Ocean ; *Phylogeny ; *Political Systems ; Taiwan
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 8
    facet.materialart.
    Unbekannt
    Medicine: diabetes in India (2011)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2011-01-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2011 Jan 27;469(7331):478-9. doi: 10.1038/469478a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21270882" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Diabetes Mellitus, Type 2/*epidemiology/genetics ; Humans ; India/epidemiology ; Motor Activity ; Prevalence
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 9
    facet.materialart.
    Unbekannt
    Dengue structure differs at host temperatures [Biophysics and Computational Biology] (2013)
    National Academy of Sciences
    Details
    Publikationsdatum: 2013-04-24
    Beschreibung: We report on a conformational transition of dengue virus when changing the temperature from that present in its mosquito vectors to that of its human host. Using cryoelectron microscopy, we show that although the virus has a smooth surface, a diameter of ∼500 Å, and little exposed membrane at room...
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Publiziert von National Academy of Sciences
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
  • 10
    facet.materialart.
    Unbekannt
    Archaeology: Sources of Chaco wood (2015)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2015-12-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, Jared -- England -- Nature. 2016 Jan 7;529(7584):31-3. doi: 10.1038/nature16864. Epub 2015 Dec 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geography, University of California, Los Angeles, Los Angeles, California 90095-1524, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26700808" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...