ALBERT

Description: In international multicenter trials, the 5-year overall survival (OS) rate of AML patients older than age 55 ranges from 5–16%. A similar outcome is seen for relapsed/refractory AML patients. As only a minority of these patients appear to benefit from myelosuppressive chemotherapy, new approaches are clearly warranted. Over 70% of AML-patients show expression of the tyrosine kinase (TK) c-Kit on myeloid blasts. c-Kit is involved in activation of proliferation pathways and plays an anti-apoptotic role in normal and malignant hematopoiesis. Imatinib mesylate (IM) inhibits protein TKs including c-Kit, PDGFRs and Abl. Two former studies have investigated IM as a single agent in patients with c-Kit positive AML and HR-MDS suggesting biological activity of IM in a subset of AML patients (Cortes, Cancer 2003; Kindler, Blood 2002). LDAC has been used for MDS and AML to induce differentiation in AML blasts with partial response rates of approximately 30% but without improvement in OS. As synergy between IM and Ara-C has been reported in vitro we conducted a phase II study applying a combination of these two agents. 40 patients at 4 centers with a median age of 72 years (range: 42–82 years with 95% of patients 〉60 y) were enrolled into this study. They either were not eligible for myelosuppressive therapy or had relapsed/refractory disease. Previous therapy included supportive care only, biological agents or 〈 3 cycles chemotherapy. In median, c-kit positivity of AML blasts from patients included was 67%. 34 patients (85%) were included with AML and 6 patients (15%) with HR-MDS (including CMML). 38 patients were evaluable for this analysis. The overall rate of biological activity was 45% (17 of 38 patients): In 6/38 (16%) patients, a blast response (reduction 〉50% in PB) was observed while 8/38 patients showed stable disease over a minimum period of 2 months. The objective response rate was low with each 1 patient (3%) showing hematologic improvement, PR and CR, respectively. While more than one third of patients included had a short term course of LDAC/IM only (80%) is spent in hospital. Study medication offered in this trial was applied in an ambulatory setting with minimal hospitalization, an early mortality rate of 21% and a low toxicity rate. In conclusion, combination therapy of LDAC/IM does not appear to be inferior in comparison to myelosuppressive therapy in older AML patients. However, this trial shows that LDAC/IM does not improve substantially the clinical outcome of older patients with AML. Identification of molecular mechanisms for good and long-term responders will be part of further laboratory investigations.

Description: From July 2002 to March 2004 the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) aboard the European Space Agency's Environmental Satellite (Envisat) measured nearly continuously mid infrared limb radiance spectra. These measurements are utilised to retrieve the global distribution of the chlorofluorocarbon CFC-11 by applying a new fast forward model for Envisat MIPAS and an accompanying optimal estimation retrieval processor. A detailed analysis shows that the total retrieval errors of the individual CFC-11 volume mixing ratios are typically below 10% and that the systematic components are dominating. Contribution of a priori information to the retrieval results are less than 5 to 10%. The vertical resolution of the observations is about 3 to 4 km. The data are successfully validated by comparison with several other space experiments, an air-borne in-situ instrument, measurements from ground-based networks, and independent Envisat MIPAS analyses. The retrieval results from 425 000 Envisat MIPAS limb scans are compiled to provide a new climatological data set of CFC-11. The climatology shows significantly lower CFC-11 abundances in the lower stratosphere compared with the Reference Atmospheres for MIPAS (RAMstan V3.1) climatology. Depending on the atmospheric conditions the differences between the climatologies are up to 30 to 110 ppt (45 to 150%) at 19 to 27 km altitude. Additionally, time series of CFC-11 mean abundance and variability for five latitudinal bands are presented. The observed CFC-11 distributions can be explained by the residual mean circulation and large-scale eddy-transports in the upper troposphere and lower stratosphere. The new CFC-11 data set is well suited for further scientific studies.

Description: From July 2002 to March 2004 the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) aboard the European Space Agency's Environmental Satellite (Envisat) measured nearly continuously mid infrared limb radiance spectra. These measurements are utilised to retrieve the global distribution of the chlorofluorocarbon CFC-11 by applying a new fast forward model for Envisat MIPAS and an accompanying optimal estimation retrieval processor. A detailed analysis shows that the total retrieval errors of the individual CFC-11 volume mixing ratios are typically below 10% in the altitude range 10 to 25 km and that the systematic components dominate. Contribution of a priori information to the retrieval results are less than 5 to 10% and the vertical resolution of the observations is about 3 to 4 km in the same vertical range. The data are successfully validated by comparison with several other space experiments, an air-borne in-situ instrument, measurements from ground-based networks, and independent Envisat MIPAS analyses. The retrieval results from 425 000 Envisat MIPAS limb scans are compiled to provide a new climatological data set of CFC-11. The climatology shows significantly lower CFC-11 abundances in the lower stratosphere compared with the Reference Atmospheres for MIPAS (RAMstan V3.1) climatology. Depending on the atmospheric conditions the differences between the climatologies are up to 30 to 110 ppt (45 to 150%) at 19 to 27 km altitude. Additionally, time series of CFC-11 mean abundance and variability for five latitudinal bands are presented. The observed CFC-11 distributions can be explained by the residual mean circulation and large-scale eddy-transports in the upper troposphere and lower stratosphere. The new CFC-11 data set is well suited for further scientific studies.

Description: This paper presents a set of observations by the CRISTA infrared limb sounder in low-earth orbit taken in August 1997 and analyses of trace-gases in the Asian Summer Monsoon (ASM) region. The spatially highly-resolved measurements of peroxyacetyl nitrate (PAN) and O3 allow a detailed analysis of an eddy-shedding event of the ASM anticyclone.We identify enhanced PAN volume mixing ratios (VMRs) within the main anticyclone and within the eddy, which are suitable as a tracer for polluted air within the ASM originating in India and China. Comparing the retrieved PAN VMRs with potential vorticity (PV) on isentropes reveals that the PAN VMRs exhibit the strongest decrease at each isentrope for an increasing value of PV which may be used to identify the extent of the ASM. Using temperature values also derived from CRISTA measurements, we also computed the location of the thermal tropopause according to the WMO criterion and find that its location agrees well with the limits of the area of increased PAN VMRs both horizontally on isentropes and vertically within the anticyclone. In contrast, the shed eddy exhibits enhanced PAN VMRs for 1 to 2 km above the thermal tropopause. Using the relationship between PAN as a tropospheric tracer and O3 as a stratospheric tracer to identify mixed air parcels, we further found the anticyclone to contain few such parcels, whereas the region in between the anticyclone and the eddy contains many mixed parcels. In combination, this implies that while the anticyclone confines polluted air masses well, eddy shedding provides a very rapid horizontal transport pathway of Asian pollution into the extratropical lowermost stratosphere with a time scale of only a few days.

Description: GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) is a new remote sensing instrument essentially combining a Fourier transform infrared spectrometer with two two-dimensional (2-D) detector arrays in combination with a highly flexible gimbal mount. It will be housed in the belly pod of the German research aircraft HALO (High Altitude and Long Range Research Aircraft). It is unique in its high spatial and spectral resolution. Furthermore, the horizontal view angle with respect to the aircraft can be varied from 45° to 135°. This allows for tomographic measurements of mesoscale events for a wide variety of atmospheric constituents. In this paper, a fast tomographic retrieval scheme is presented, which is able to fully exploit the high-resolution radiance observations of the GLORIA limb sounder. The algorithm is optimized for massive 3-D retrievals of several hundred thousands of measurements and atmospheric constituents on common hardware. The new scheme is used to explore the capabilities of GLORIA to sound the atmosphere in full 3-D with respect to the choice of the flightpath and to different measurement modes of the instrument using ozone as a test species. It is demonstrated that the achievable resolution should approach 200 m vertically and 20 km–30 km horizontally. Finally, a comparison of the 3-D inversion with conventional 1-D inversions using the assumption of a horizontally homogeneous atmosphere is performed.

Description: Infrared limb sounding from aircraft can provide 2-D curtains of multiple trace gas species. However, conventional limb sounders view perpendicular to the aircraft axis and are unable to resolve the observed airmass along their line-of-sight. GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) is a new remote sensing instrument able to adjust its horizontal view angle with respect to the aircraft flight direction from 45° to 135°. This will allow for tomographic measurements of mesoscale structures for a wide variety of atmospheric constituents. Many flights of the GLORIA instrument will not follow closed curves that allow measuring an airmass from all directions. Consequently, it is examined by means of simulations, what results can be expected from tomographic evaluation of measurements made during a straight flight. It is demonstrated that the achievable resolution and stability is enhanced compared to conventional retrievals. In a second step, it is shown that the incorporation of channels exhibiting different optical depth can greatly enhance the 3-D retrieval quality enabling the exploitation of previously unused spectral samples. A second problem for tomographic retrievals is that advection, which can be neglected for conventional retrievals, plays an important role for the time-scales involved in a tomographic measurement flight. This paper presents a method to diagnose the effect of a time-varying atmosphere on a 3-D retrieval and demonstrates an effective way to compensate for effects of advection by incorporating wind-fields from meteorological datasets as a priori information.

Description: PREMIER is one of three candidates for ESA's 7th Earth Explorer mission that are currently undergoing feasibility studies. The main mission objective of PREMIER is to quantify processes controlling atmospheric composition in the mid/upper troposphere and lower stratosphere, a region of particular importance for climate change. To achieve this objective, PREMIER will employ the first satellite Fourier transform infrared limb-imager with a 2-D detector array combined with a millimetre-wave limb-sounder. The infrared limb-imager can be operated in a high spatial resolution mode ("dynamics mode") for observations of small-scale structures in atmospheric temperatures and trace gas fields with unprecedented 3-D sampling (0.5 km in the vertical direction, 50 km along track, 25 km across track). In this paper, a fast tomographic retrieval scheme is presented, which is designed to fully exploit the high-resolution radiance observations of the dynamics mode. Based on a detailed analysis of the "observational filter", we show that the dynamics mode provides unique information on global distributions of gravity waves (GW). The achievable vertical resolution for GW observations has values between the vertical sampling (0.5 km) of the dynamics mode and the vertical field of view (about 0.75 km). The horizontal across track resolution corresponds to the horizontal across track sampling of 25 km. Since the achievable along track horizontal resolution is about 70 km, the dynamics mode will provide GW limb-observations with a horizontal resolution comparable to nadir sounders. Compared to previous observations, PREMIER will therefore considerably extend the range of detectable GWs in terms of horizontal and vertical wavelength.

Description: Infrared limb sounding from aircraft can provide 2-D curtains of multiple trace gas species. However, conventional limb sounders view perpendicular to the aircraft axis and are unable to resolve the observed airmass along their line-of-sight. GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) is a new remote sensing instrument that is able to adjust its horizontal view angle with respect to the aircraft flight direction from 45° to 135°. This will allow for tomographic measurements of mesoscale structures for a wide variety of atmospheric constituents. Many flights of the GLORIA instrument will not follow closed curves that allow measuring an airmass from all directions. Consequently, it is examined by means of simulations, what spatial resolution can be expected under ideal conditions from tomographic evaluation of measurements made during a straight flight. It is demonstrated that the achievable horizontal resolution in the line-of-sight direction could be reduced from over 200 km to around 70 km compared to conventional retrievals and that the tomographic retrieval is also more robust against horizontal gradients in retrieved quantities in this direction. In a second step, it is shown that the incorporation of channels exhibiting different optical depth can further enhance the spatial resolution of 3-D retrievals enabling the exploitation of spectral samples usually not used for limb sounding due to their opacity. A second problem for tomographic retrievals is that advection, which can be neglected for conventional retrievals, plays an important role for the time-scales involved in a tomographic measurement flight. This paper presents a method to diagnose the effect of a time-varying atmosphere on a 3-D retrieval and demonstrates an effective way to compensate for effects of advection by incorporating wind-fields from meteorological datasets as a priori information.

Description: We report first chemistry mode retrieval results from the new airborne limb-imaging infrared FTS (Fourier transform spectrometer) GLORIA (Gimballed Limb Observer for Radiance Imaging of the Atmosphere) and comparisons with observations by the conventional airborne limb-scanning infrared FTS MIPAS-STR (Michelson Interferometer for Passive Atmospheric Sounding – STRatospheric aircraft). For GLORIA, the flights aboard the high-altitude research aircraft M55 Geophysica during the ESSenCe campaign (ESa Sounder Campaign 2011) were the very first in field deployment after several years of development. The simultaneous observations of GLORIA and MIPAS-STR during the flight on 16 December 2011 inside the polar vortex and under conditions of optically partially transparent polar stratospheric clouds (PSCs) provided us the first opportunity to compare the observations by two different infrared FTS generations directly. We validate the GLORIA results with MIPAS-STR based on the lower vertical resolution of MIPAS-STR and compare the vertical resolutions of the instruments derived from their averaging kernels. The retrieval results of temperature, HNO3, O3, H2O, CFC-11 and CFC-12 show reasonable agreement of GLORIA with MIPAS-STR and collocated in situ observations. For the horizontally binned hyperspectral limb images, the GLORIA sampling outnumbered the horizontal cross-track sampling of MIPAS-STR by up to 1 order of magnitude. Depending on the target parameter, typical vertical resolutions of 0.5 to 2.0 km were obtained for GLORIA and are typically a factor of 2 to 4 better compared to MIPAS-STR. While the improvement of the performance, characterization and data processing of GLORIA are the subject of ongoing work, the presented first results already demonstrate the considerable gain in sampling and vertical resolution achieved with GLORIA.