Publication Date:
1989-10-13
Description:
Autologous peripheral nerve grafts were used to permit and direct the regrowth of retinal ganglion cell axons from the eye to the ipsilateral superior colliculus of adult hamsters in which the optic nerves had been transected within the orbit. Extracellular recordings in the superior colliculus 15 to 18 weeks after graft insertion revealed excitatory and inhibitory postsynaptic responses to visual stimulation. The finding of light-induced responses in neurons in the superficial layers of the superior colliculus close to the graft indicates that axons regenerating from axotomized retinal ganglion cells can establish electrophysiologically functional synapses with neurons in the superior colliculus of these adult mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keirstead, S A -- Rasminsky, M -- Fukuda, Y -- Carter, D A -- Aguayo, A J -- Vidal-Sanz, M -- New York, N.Y. -- Science. 1989 Oct 13;246(4927):255-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurosciences Unit, Montreal General Hospital, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2799387" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials/drug effects
;
Animals
;
Axons/physiology
;
Cricetinae
;
Mesocricetus
;
Nerve Regeneration/*physiology
;
Optic Nerve/*physiology
;
Photic Stimulation
;
Retinal Ganglion Cells/physiology
;
Superior Colliculi/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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