Publication Date:
1999-01-05
Description:
Recently, GBR1, a seven-transmembrane domain protein with high affinity for gamma-aminobutyric acid (GABA)B receptor antagonists, was identified. Here, a GBR1-related protein, GBR2, was shown to be coexpressed with GBR1 in many brain regions and to interact with it through a short domain in the carboxyl-terminal cytoplasmic tail. Heterologously expressed GBR2 mediated inhibition of adenylyl cyclase; however, inwardly rectifying potassium channels were activated by GABAB receptor agonists only upon coexpression with GBR1 and GBR2. Thus, the interaction of these receptors appears to be crucial for important physiological effects of GABA and provides a mechanism in receptor signaling pathways that involve a heterotrimeric GTP-binding protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuner, R -- Kohr, G -- Grunewald, S -- Eisenhardt, G -- Bach, A -- Kornau, H C -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):74-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉BASF-LYNX Bioscience AG, Department of Neuroscience, Im Neuenheimer Feld 515, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9872744" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclase Inhibitors
;
Amino Acid Sequence
;
Animals
;
Brain/*metabolism
;
Cell Line
;
Cyclic AMP/metabolism
;
Dimerization
;
G Protein-Coupled Inwardly-Rectifying Potassium Channels
;
GABA-B Receptor Agonists
;
Humans
;
In Situ Hybridization
;
Molecular Sequence Data
;
Neurons/metabolism
;
Potassium/metabolism
;
Potassium Channels/metabolism
;
*Potassium Channels, Inwardly Rectifying
;
RNA, Messenger/genetics/metabolism
;
Rats
;
Receptors, GABA/*chemistry/*metabolism
;
Receptors, GABA-B/*chemistry/*metabolism
;
Recombinant Fusion Proteins/chemistry/metabolism
;
Sequence Alignment
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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