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  • Springer Nature  (41)
  • American Association for the Advancement of Science (AAAS)  (17)
  • 1
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    Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance (2016)
    Springer Nature
    In: Nature
    Details
    Publication Date: 2016-05-05
    Description: Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance Nature 533, 7601 (2016). doi:10.1038/nature17938 Authors: Ahmed H. Badran, Victor M. Guzov, Qing Huai, Melissa M. Kemp, Prashanth Vishwanath, Wendy Kain, Autumn M. Nance, Artem Evdokimov, Farhad Moshiri, Keith H. Turner, Ping Wang, Thomas Malvar & David R. Liu The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits. The development of insect resistance to Bt toxins endangers their long-term effectiveness. Here we have developed a phage-assisted continuous evolution selection that rapidly
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    A new raptorial dinosaur with exceptionally long feathering provides insights into dromaeosaurid flight performance (2014)
    Springer Nature
    Details
    Publication Date: 2014-07-17
    Description: Article Microraptorines are a group of dromaeosaurids known for having some degree of aerodynamic capacity. Here, the authors describe a new four-winged Early Cretaceous microraptorine from China, with a remarkably long-feathered tail, and show how the tail might have helped with landing. Nature Communications doi: 10.1038/ncomms5382 Authors: Gang Han, Luis M. Chiappe, Shu-An Ji, Michael Habib, Alan H. Turner, Anusuya Chinsamy, Xueling Liu, Lizhuo Han
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 3
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    Dynamics of ribozyme binding of substrate revealed by fluorescence-detected stopped-flow methods (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-11-20
    Description: Fluorescence-detected stopped-flow and equilibrium methods have been used to study the mechanism for binding of pyrene (pyr)-labeled RNA oligomer substrates to the ribozyme (catalytic RNA) from Tetrahymena thermophila. The fluorescence of these substrates increases up to 25-fold on binding to the ribozyme. Stopped-flow experiments provide evidence that pyr experiences at least three different microenvironments during the binding process. A minimal mechanism is presented in which substrate initially base pairs to ribozyme and subsequently forms tertiary contacts in an RNA folding step. All four microscopic rate constants are measured for ribozyme binding of pyrCCUCU.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevilacqua, P C -- Kierzek, R -- Johnson, K A -- Turner, D H -- GM 22939/GM/NIGMS NIH HHS/ -- GM44613/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1992 Nov 20;258(5086):1355-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Rochester, NY 14627.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1455230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydrogen Bonding ; Kinetics ; *RNA Splicing ; RNA, Catalytic/*metabolism ; RNA, Guide/*metabolism ; RNA, Protozoan/*metabolism ; RNA, Ribosomal/*metabolism ; Substrate Specificity ; Tetrahymena thermophila ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Prevalence of AIDS-related risk factors and condom use in the United States (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-11-13
    Description: A national probability survey of human immunodeficiency virus (HIV)-related risk factors among the general heterosexual population, the National AIDS (acquired immunodeficiency syndrome) Behavioral Surveys, has obtained data from 10,630 respondents. Data are presented on the prevalence of HIV-related risks in the general heterosexual population, on the distribution of the three largest risk groups across social strata, and on the prevalence and distribution of condom use among heterosexuals reporting a risk factor. Between 15 and 31 percent of heterosexuals nationally and 20 and 41 percent in cities with a high prevalence of AIDS reported an HIV risk factor. Condom use was relatively low. Only 17 percent of those with multiple sexual partners, 12.6 percent of those with risky sexual partners, and 10.8 percent of untested transfusion recipients used condoms all the time. Overall, the results suggest that current HIV prevention programs have, to a very limited extent, reached those heterosexuals with multiple sexual partners but have failed to reach many other groups of the heterosexual population at risk for HIV. New public health strategies may be needed for these specific risk groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Catania, J A -- Coates, T J -- Stall, R -- Turner, H -- Peterson, J -- Hearst, N -- Dolcini, M M -- Hudes, E -- Gagnon, J -- Wiley, J -- MH43892/MH/NIMH NIH HHS/ -- MH46240/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1992 Nov 13;258(5085):1101-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1439818" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/prevention & control ; Adolescent ; Adult ; Age Factors ; Aged ; Blood Transfusion ; *Condoms ; Continental Population Groups ; Female ; HIV Seropositivity ; Health Surveys ; Hemophilia A/complications ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Regression Analysis ; Risk Factors ; Sexual Behavior ; Sexual Partners ; Substance Abuse, Intravenous ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    A Late Triassic dinosauromorph assemblage from New Mexico and the rise of dinosaurs (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-07-21
    Description: It has generally been thought that the first dinosaurs quickly replaced more archaic Late Triassic faunas, either by outcompeting them or when the more archaic faunas suddenly became extinct. Fossils from the Hayden Quarry, in the Upper Triassic Chinle Formation of New Mexico, and an analysis of other regional Upper Triassic assemblages instead imply that the transition was gradual. Some dinosaur relatives preserved in this Chinle assemblage belong to groups previously known only from the Middle and lowermost Upper Triassic outside North America. Thus, the transition may have extended for 15 to 20 million years and was probably diachronous at different paleolatitudes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Irmis, Randall B -- Nesbitt, Sterling J -- Padian, Kevin -- Smith, Nathan D -- Turner, Alan H -- Woody, Daniel -- Downs, Alex -- New York, N.Y. -- Science. 2007 Jul 20;317(5836):358-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum of Paleontology and Department of Integrative Biology, University of California, Berkeley, CA 94720-4780, USA. irmis@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17641198" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Dinosaurs/anatomy & histology/classification ; Femur/anatomy & histology ; *Fossils ; New Mexico ; Phylogeny ; Talus/anatomy & histology ; Tibia/anatomy & histology ; Time ; Tooth/anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Closing a loophole in the FDA Amendments Act (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turner, Erick H -- New York, N.Y. -- Science. 2008 Oct 3;322(5898):44-6. doi: 10.1126/science.322.5898.44c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18832629" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/*legislation & jurisprudence ; Databases, Factual ; Disclosure ; Drug Approval ; Humans ; Registries ; United States ; United States Food and Drug Administration/*legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-11-20
    Description: Exome sequencing studies of autism spectrum disorders (ASDs) have identified many de novo mutations but few recurrently disrupted genes. We therefore developed a modified molecular inversion probe method enabling ultra-low-cost candidate gene resequencing in very large cohorts. To demonstrate the power of this approach, we captured and sequenced 44 candidate genes in 2446 ASD probands. We discovered 27 de novo events in 16 genes, 59% of which are predicted to truncate proteins or disrupt splicing. We estimate that recurrent disruptive mutations in six genes-CHD8, DYRK1A, GRIN2B, TBR1, PTEN, and TBL1XR1-may contribute to 1% of sporadic ASDs. Our data support associations between specific genes and reciprocal subphenotypes (CHD8-macrocephaly and DYRK1A-microcephaly) and replicate the importance of a beta-catenin-chromatin-remodeling network to ASD etiology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528801/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528801/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Roak, Brian J -- Vives, Laura -- Fu, Wenqing -- Egertson, Jarrett D -- Stanaway, Ian B -- Phelps, Ian G -- Carvill, Gemma -- Kumar, Akash -- Lee, Choli -- Ankenman, Katy -- Munson, Jeff -- Hiatt, Joseph B -- Turner, Emily H -- Levy, Roie -- O'Day, Diana R -- Krumm, Niklas -- Coe, Bradley P -- Martin, Beth K -- Borenstein, Elhanan -- Nickerson, Deborah A -- Mefford, Heather C -- Doherty, Dan -- Akey, Joshua M -- Bernier, Raphael -- Eichler, Evan E -- Shendure, Jay -- HD065285/HD/NICHD NIH HHS/ -- HL-102923/HL/NHLBI NIH HHS/ -- HL-102924/HL/NHLBI NIH HHS/ -- HL-102925/HL/NHLBI NIH HHS/ -- HL-102926/HL/NHLBI NIH HHS/ -- HL-103010/HL/NHLBI NIH HHS/ -- NS069605/NS/NINDS NIH HHS/ -- R01 HD065285/HD/NICHD NIH HHS/ -- R01 NS064077/NS/NINDS NIH HHS/ -- R01 NS069605/NS/NINDS NIH HHS/ -- RC2 HL102926/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Dec 21;338(6114):1619-22. doi: 10.1126/science.1227764. Epub 2012 Nov 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23160955" target="_blank"〉PubMed〈/a〉
    Keywords: Cephalometry ; Child ; Child Development Disorders, Pervasive/*genetics ; Child, Preschool ; Chromatin Assembly and Disassembly ; Cohort Studies ; DNA Probes ; DNA-Binding Proteins/genetics ; Exome ; Female ; *Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Megalencephaly/genetics ; Microcephaly/genetics ; *Mutation ; Nuclear Proteins/genetics ; PTEN Phosphohydrolase/genetics ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, N-Methyl-D-Aspartate/genetics ; Repressor Proteins/genetics ; Sequence Analysis, DNA/*methods ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; beta Catenin/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-29
    Description: Store-operated Ca2+ entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels following Ca2+ release from intracellular stores. We performed a genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins that inhibit store-operated Ca2+ influx. A secondary patch-clamp screen identified CRACM1 and CRACM2 (CRAC modulators 1 and 2) as modulators of Drosophila CRAC currents. We characterized the human ortholog of CRACM1, a plasma membrane-resident protein encoded by gene FLJ14466. Although overexpression of CRACM1 did not affect CRAC currents, RNAi-mediated knockdown disrupted its activation. CRACM1 could be the CRAC channel itself, a subunit of it, or a component of the CRAC signaling machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vig, M -- Peinelt, C -- Beck, A -- Koomoa, D L -- Rabah, D -- Koblan-Huberson, M -- Kraft, S -- Turner, H -- Fleig, A -- Penner, R -- Kinet, J-P -- 5-R37-GM053950/GM/NIGMS NIH HHS/ -- R01-AI050200/AI/NIAID NIH HHS/ -- R01-GM065360/GM/NIGMS NIH HHS/ -- R01-NS040927/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. mvig@bidmc.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16645049" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*metabolism ; Calcium Channels/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Drosophila Proteins/*genetics/*metabolism ; Drosophila melanogaster/*metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Ion Transport ; Jurkat Cells ; Membrane Proteins/genetics/*metabolism ; Patch-Clamp Techniques ; RNA Interference ; RNA, Small Interfering ; Reverse Transcriptase Polymerase Chain Reaction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Stimulus- and goal-oriented frameworks for understanding natural vision (2018)
    Springer Nature
    Details
    Publication Date: 2018
    Print ISSN: 1097-6256
    Electronic ISSN: 1546-1726
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 10
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    An NAD derivative produced during transfer RNA splicing: ADP-ribose 1"-2" cyclic phosphate (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-07-09
    Description: Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2' phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NAD)-dependent phosphotransferase catalyzes removal of the 2' phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP)-ribose 1"-2" cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culver, G M -- McCraith, S M -- Zillmann, M -- Kierzek, R -- Michaud, N -- LaReau, R D -- Turner, D H -- Phizicky, E M -- DE07202-02/DE/NIDCR NIH HHS/ -- GM 22939/GM/NIGMS NIH HHS/ -- GM 25349/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Jul 9;261(5118):206-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Rochester School of Medicine and Dentistry, NY 14642.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8392224" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate Ribose/*analogs & derivatives/chemistry/metabolism ; Animals ; Cyclic ADP-Ribose ; Endoribonucleases/metabolism ; NAD/chemistry/metabolism ; Oocytes/metabolism ; Phosphates/metabolism ; Phosphorylation ; Phosphotransferases/metabolism ; *RNA Splicing ; RNA, Fungal/*metabolism ; RNA, Transfer/*metabolism ; Saccharomyces cerevisiae/*genetics ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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