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  • Articles  (52)
  • Wiley  (20)
  • Springer  (18)
  • American Association for the Advancement of Science (AAAS)  (14)
  • Frontiers Media
  • ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften, Leibniz-Informationszentrum Wirtschaft Kiel, Hamburg
  • Chemistry and Pharmacology  (52)
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  • Articles  (52)
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  • 1
    Electronic Resource
    Electronic Resource
    Die elektrische Volumenmessung von Blutzellen bei der Erythropoese, bei Rauchern, Herzinfarkt- und Leukämiepatienten sowie von Leberzellkernen (1974)
    Springer
    Naturwissenschaften 61 (1974), S. 260-266 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595658
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  • 2
    Electronic Resource
    Electronic Resource
    On the role of solvent in complexation equilibiria. II. The acid-base chemistry of some sulfhydryl and ammonium-containing amino acids in water—acetonitrile mixed solvents (1979)
    Springer
    Journal of solution chemistry 8 (1979), S. 635-646 
    Details
    ISSN: 1572-8927
    Keywords: Amino acids ; cysteine ; penicillamine ; glutathione ; microscopic ionization ; mixed solvents ; water-acetonitrile ; potentiometry ; ultraviolet spectroscopy ; acid-base chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The macroscopic and microscopic acid-base chemistry of a series of sulfhydryl and ammonium-containing amino acids HS−R−NH3 [R=−CH2CH(COOH)−, cysteine (CYS); R=−C(CH3)2CH(COOH)−, penicillamine (PEN); R=−CH(COOH)CH2CH2CONHCH(−CH2)CONHCH2COOH, glutathione (GSH)] was characterized in water and its binary mixtures with acetonitrile (16.3, 34.2, and 53.9 mass % acetonitrile). Macroscopic acid dissociation constants were obtained by potentiometric titration using the glass-calomel electrode pair. Microscopic acid dissociation constants were calculated from ultraviolet absorption measurements at ca. 232 nm where the deprotonated sulfhydryl group absorbs. The macroscopic constants decrease uniformly as the solvent becomes enriched in acetonitrile. The microscopic constants, which characterize the relative concentrations of the two monoprotonated tautomers of the molecules (I and II) reveal that as the solvent becomes enriched in acetonitrile, the fraction of molecules existing as highly charged tautomer I decreases for CYS (0.68–0.40), PEN (0.85–0.34), and GSH (0.61–0.30). These results are related to the decreasing concentration of water as the solvent becomes enriched in acetonitrile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01033694
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  • 3
    Electronic Resource
    Electronic Resource
    Structure–Metabolism Relationships in the Hydrolysis of Nicotinate Esters by Rat Liver and Brain Subcellular Fractions (1991)
    Springer
    Pharmaceutical research 8 (1991), S. 832-839 
    Details
    ISSN: 1573-904X
    Keywords: nicotinic acid esters ; carboxylesterases ; subcellular fractions ; structure–metabolism relationships
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Rat liver and brain subcellular esterase activities toward nicotinic acid esters were studied, under varying conditions, such as pH, organic solvents, protein concentration, duration of incubation, and substrate concentration. Esterases in each subcellular fraction displayed activities that obey Michaelis–Menten kinetics, although subcellular fractions are heterogeneous. The K m values were of the same magnitude, and the V max values were lower in microsomes than in cytosol of the liver. Brain activities normalized to protein concentration, were much lower than liver activities, aromatic nicotinates being the best substrates in both tissues. Myelin and brain mitochondria of nerve-ending and neuroglial origin display esterase activity toward phenyl nicotinate. In contrast to brain esterases, liver esterases appear homogeneous, and esterase activities in both tissues react differently to changes in pH. Qualitative and quantitative structure–metabolism relationships are not suggestive of tissue-specific ester hydrolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015839109449
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  • 4
    Electronic Resource
    Electronic Resource
    Uncoupling Protein 3: Its Possible Biological Role and Mode of Regulation in Rodents and Humans (1999)
    Springer
    Journal of bioenergetics and biomembranes 31 (1999), S. 467-473 
    Details
    ISSN: 1573-6881
    Keywords: Uncoupling proteins ; fatty acids ; skeletal muscle ; brown adipose tissue ; obesity ; thermogenesis ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The recently discovered uncoupling protein 3 (UCP3) is highly homologous to the mitochondrialinner membrane protein UCP1, which generates heat by uncoupling the respiratory chainfrom oxidative phosphorylation. The thermogenic function of UCP1 protects against cold andregulates the energy balance in rodents. We review in vitro studies investigating the uncouplingactivity of UCP3 and in vivo studies, which address UCP3 gene expression in brown adiposetissue and skeletal muscle under various metabolic conditions. The data presented are, for themost, consistent with an uncoupling role for UCP3 in regulatory thermogenesis. We alsodiscuss mediators of UCP3 regulation and propose a potential role for intracellular fatty acidsin the mechanism of UCP3 modulation. Finally, we hypothesize a role for UCP3 in themetabolic adaptation of the mitochondria to the degradation of fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005448423731
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  • 5
    Electronic Resource
    Electronic Resource
    A low molecular weight substance purified from human placenta inhibits cAMP-dependent protein kinase and activates protein kinase C (1997)
    Springer
    Molecular and cellular biochemistry 170 (1997), S. 75-83 
    Details
    ISSN: 1573-4919
    Keywords: cAMP-dependent protein kinase ; protein kinase C ; phospholipid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract We have purified from human placenta a low molecular mass substance that inhibits cAMP-dependent protein kinase and activates protein kinase C. This protein kinase regulator was purified in three steps: (1) homogenizing placentas in chloroform/methanol and extracting the regulator into water; (2) eluting a strong anion exchange high performance liquid chromatography (HPLC) column with a quaternary gradient; and (3) eluting a reversed-phase HPLC column with a binary gradient. The regulator was found to be highly purified by HPLC, thin-layer chromatography (TLC) and laser desorption ionization mass spectrometry with a molecular mass of 703 Daltons by the latter procedure. The physical and biochemical properties of this protein kinase regulator suggest that it is a phospholipid but it did not co-elute by HPLC or by TLC with any of the known phospholipid activators of protein kinase C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006836826926
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  • 6
    Electronic Resource
    Electronic Resource
    Decreased phosphorylation of a low molecular weight protein by cGMP-dependent protein kinase in variant HL-60 cells resistant to nitric oxide- and cGMP-induced differentiation (1998)
    Springer
    Molecular and cellular biochemistry 185 (1998), S. 111-121 
    Details
    ISSN: 1573-4919
    Keywords: HL-60 cells ; differentiation ; cGMP-dependent protein kinase ; nitric oxide ; cGMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract We previously described the isolation of a variant subline of HL-60 cells that does not differentiate in response to nitric oxide (NO)-generating agents or to cGMP analogs [7]. The variant cells have normal guanylate cyclase activity and normal NO-induced increases in the intracellular cGMP concentration. We now show that the variant cells have normal cGMP-dependent protein kinase (G-kinase) activity, both by an in vitro and in vivo assay, and using two-dimensional gel electrophoresis we have identified six G-kinase substrates in the parental cells. Of these six proteins, we found considerably less phosphorylation of one of the proteins in the variant cells than in parental cells, both in vitro and in intact cells, and by 35S-methionine/35S-cysteine incorporation we found much less of this protein in the variant cells than in parental cells. The protein is a shared substrate of cAMP-dependent protein kinase (A-kinase); since cAMP analogs still induce differentiation of the variant cells, it appears that the NO/cGMP/G-kinase and cAMP/A-kinase signal transduction pathways share some but not all of the same target proteins in inducing differentiation of HL-60 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006834324419
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  • 7
    Electronic Resource
    Electronic Resource
    Atomgewichte für 1929 (1929)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 77 (1929), S. 217-221 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01362192
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  • 8
    Electronic Resource
    Electronic Resource
    Eine verbesserte fluorimetrische Serumcortisolbestimmung (1970)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 252 (1970), S. 284-287 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Durch täglich frische Zubereitung eines stabilen Fluorescenzreagenses, durch Fluorimetrie 80 min nach Zugabe des Fluorescenzreagenses zum dichlormethanextrahierten Cortisol, durch streng blasenfreie Füllung einer Spezialmikroküvette mittels Pumpvorrichtung und durch optimale Messung der Cortisolfluorescenz im registrierenden Spektralfluorimeter bei 464 nm (Anregung) und 522 nm (Emission) wurde die fluorimetrische Serumcortisolbestimmung verbessert. Die Methode erlaubt eine Serumcortisolbestimmung mit hoher Empfindlichkeit (〈 1 μg/100 ml), Präzision an einem Tag (Variationskoeffizient = 4,7% für 10 μg/ 100 ml) und Präzision von Tag zu Tag (VK=6–7%, Kontrollserum). Für die Spezifität der Methode sprechen die niedrigen Serumcortisolwerte von Adrenalektomierten unter Dexamethasonsubstitution (〈 2 μg/100 ml). Die klinische Brauchbarkeit der Methode für diagnostische und therapeutische Fragen wird diskutiert.
    Notes: Abstract The fluorometric determination of cortisol in serum was improved by the following measures: 1. Daily preparation of the fluorescence reagent (ethanol abs.: conc. H2SO4= 3∶7, v/v) at 0°C. 2. Fluorometry 80 min after the addition of the fluorescence reagent to dichloromethane extracted cortisol. 3. Filling of a special micro-cuvette by a pump system avoiding bubble formation in the cuvette. 4. Spectrofluorometer with optimal absorption (464 nm) and emission (522 nm) for cortisol. The method is of satisfactory sensitivity for cortisol (〈 1 μg/100 ml), precision (10 μg/100 ml ∶ S.D. = 0.5 μg/ 100 ml) and reproducibility from day to day (variation coefficient = 6–7%). The specificity of the method is demonstrated by the low values (〈 2 μg/100 ml) of total-adrenalectomized patients under dexamethasone maintainance (2 × 0.25 mg/day). The normal range (mean ± 2 S.D., logarithmic distribution) of 900 a.m. serum cortisol values of control persons is 9.7–32.0 μg/100 ml. Examples of the application of the method for diagnostic and therapeutic questions are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571352
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  • 9
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    Radio-microanalytical particle measurements method and application to Fukushima aerosols collected in Japan (2012)
    Springer
    Details
    Publication Date: 2012-08-26
    Print ISSN: 0236-5731
    Electronic ISSN: 1588-2780
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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  • 10
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    Response to comment by S. Chiswell (2013)
    Wiley
    Details
    Publication Date: 2013-11-28
    Description: [1]   Chiswell [2013] suggests that some of the conclusions drawn by Behrenfeld et al . [2013] are likely erroneous because of (1) the method used to calculate specific net biomass accumulation rates ( r ; d -1 ) over the seasonal cycle, (2) inconsistencies in the calculation of r and phytoplankton specific cell division rate, μ (d -1 ), and (3) uncertainties in the extrapolation of satellite data to the depth of the seasonal thermocline. Each of these concerns is addressed in the following subsections. We begin with a simple culture-based analogy that clarifies why switching between concentration-based and inventory-based expressions is required for calculating r when the mixed layer varies between shoaling and deepening conditions. This analogy is followed by a more specific mathematical treatment. We then explain why our previous comparisons between r and μ provide a conservative estimate of predator-prey coupling, followed by a discussion of uncertainties in satellite-based assessments of mixed layer phytoplankton biomass.
    Print ISSN: 0886-6236
    Electronic ISSN: 1944-9224
    Topics: Biology , Chemistry and Pharmacology , Geography , Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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