Publication Date:
1991-09-20
Description:
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cortex. Activation of postsynaptic GABAA receptors hyperpolarizes cells and inhibits neuronal activity. Synaptic responses mediated by GABAA receptors also strongly excited hippocampal neurons. This excitatory response was recorded in morphologically identified interneurons in the presence of 4-aminopyridine or after elevation of extracellular potassium concentrations. The synaptic excitation sustained by GABAA receptors synchronized the activity of inhibitory interneurons. This synchronized discharge of interneurons in turn elicited large-amplitude inhibitory postsynaptic potentials in pyramidal and granule cells. Excitatory synaptic responses mediated by GABAA receptors may thus provide a mechanism for the recruitment of GABAergic interneurons through their recurrent connections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michelson, H B -- Wong, R K -- New York, N.Y. -- Science. 1991 Sep 20;253(5026):1420-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, State University of New York, Brooklyn 11203.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1654594" target="_blank"〉PubMed〈/a〉
Keywords:
4-Aminopyridine/pharmacology
;
Animals
;
Atropine/*pharmacology
;
Evoked Potentials/drug effects
;
Guinea Pigs
;
Hippocampus/*physiology
;
In Vitro Techniques
;
Membrane Potentials/drug effects
;
Neurons/drug effects/*physiology
;
Propranolol/*pharmacology
;
Receptors, GABA-A/drug effects/*physiology
;
Synapses/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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