ISSN:
1432-119X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Parenteral use of Alcian Blue in rabbits leads to apparent staining of glomerular basement membrane acutely but there is a particularization of the dye in mesangial structures and endothelial cells during the second to fourteenth day following injection. Membranous structures in pancreas, stomach and small intestine are also colored, possibly stained. The effect in the kidney and perhaps in other structures may be a non-specific one, based on filtration of the dye through such a naturally positioned barrier as basement membrane. A comparison of in vivo and in vitro staining patterns showed marked similarity in the deposition of the dye, suggesting specificity of the in vivo staining pattern. But the alteration of “staining” patterns with time could be construed as arguing against specificity. In the generalized Shwartzman reaction, Alcian Blue stained glomerular occlusive deposits, lending credence to, but not proving, the hypothesis that an acid mucopolysaccharide, with altered fibrinogen, may be implicated in the formation of glomerular aggregates in the Shwartzmann phenomenon.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00311402
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