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  • 1
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischinger, P J -- Blevins, C S -- Dunlop, N M -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genes, Viral ; Glycoproteins/immunology ; Leukemia, Experimental/*microbiology ; Lymphoma/*microbiology ; Mice ; Mice, Inbred BALB C/microbiology ; Mice, Inbred Strains/microbiology ; Moloney murine leukemia virus/classification/*genetics/immunology ; Recombination, Genetic ; Species Specificity ; Viral Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Cosmic X-ray observations with OSO-8 (1976)
    In:  CASI
    Details
    Publication Date: 2006-01-12
    Description: The GSFC Cosmic X-ray Spectroscopy experiment aboard OSO-8 has operated successfully since launch providing spectral and temporal data on X-ray sources in tha energy range 2-60 keV. Analysis of quick look data shows a variety of spectral features, some stable, others variable, which will increase understanding of the nature of individual sources. In particular, observed emission and absorption features that can be attributed to iron will result in abundance measures of this important element in sources such as some X-ray binaries, the supernova remnant Cas A, and the nucleus of the galaxy Cen A.
    Keywords: SPACE RADIATION
    Type: X-ray Binaries; p 67-79
    Format: text
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  • 4
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    The Large Area Crop Inventory Experiment (LACIE). Part 2: Yield estimates from meteorological information (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Crop-weather models developed for wheat from an assembled base of approximately 45 years of climatic records and historic wheat yield and production data at the stratum level are described. Utilization of meteorological data acquired by the NOAA satellites is discussed.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Lyndon B. Johnson Space Center NASA Earth Resources Survey Symp., Vol. 2-A; p 63-65
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  • 5
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    Galactic center iron line emission (1978)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Data from the Goddard Space Flight Center experiment on HEAO 1 were examined for galactic center iron line emission. Evidence for a 6.8 keV line from the summed flux within 10 deg longitude and 10 deg latitude of the galactic center was found; however, firm limits cannot be put on the intrinsic line width. If the line emission is diffuse and cosmic-ray-induced, the calculations of Bussard et al (1978) yield an upper limit to c-12 4.44 MeV line emission, which is not inconsistent with the results of Haymes et al (1975). Significant contributions to the iron line from discrete sources can not be ruled out.
    Keywords: SPACE RADIATION
    Type: Gamma Ray Spectry. in Astrophys.; p 302-309
    Format: text
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  • 6
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    The measurements of latitude, time, and height variations at a single laser tracking station (1977)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Recent analysis of laser data for determining variation of latitude have been based on apparent variations in the orbital inclination of the satellite derived from short orbital arcs of 6-8 hours. An alternative method, based on the daily adjustment of the station position to a much longer arc of 2 or 3 weeks has recently been developed and tested. In the new method a long orbital arc is derived from many days of data and is subsequently used as a reference orbit for the adjustment of the position of the station (only) on each day of the long arc for which tracking data are available. This new technique appears to give slightly better results when it is applied to a test period in August 1970, with the added advantage that earth rotation measurements can be derived from the same data at the same time. The results for the test period indicate a precision of 74 cm in variation of latitude and 0.81 ms in monitoring the earth's rotation with 6 hours of data.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Journal of Geophysical Research; 82; Feb. 10
    Format: text
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  • 7
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    Possible role of remote sensing for increasing public awareness of the Chesapeake Bay environment (1978)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Application of remote sensing techniques to the study of the Chesapeake Bay and the availability of the resulting information are discussed in terms of public awareness of the Chesapeake Bay, its total environment, and the need to protect that environment and to preserve the Bay. Recommendations given include: (1) continue the study of remote sensing technology and its use in the Chesapeake Bay region; (2) emphasize the importance of LANDSAT imagery to the evolution of remote sensing technological developments and the awareness of the environment and its changes; (3) increase dissemination of information of the environmental applications of remote sensing technology to the public; (4) design surveys of the Chesapeake Bay environment and its manmade changes; and (5) establish a coordinating regional institution to develop a management plan for the Chesapeake Bay.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Appl. of Remote Sensing to the Chesapeake Bay Reg.; p 323-326
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  • 8
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    Present status of LANDSAT remote sensing (1978)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: The state-of-the-practice of satellite remote sensing is examined. Emphasis is placed on the use of remote sensing to improve information gathering practices. Impediments to adopting this technology and opportunities to overcome these impediments are addressed.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Appl. of Remote Sensing to the Chesapeake Bay Reg.; p 21-23
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  • 9
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    A measurement of cosmic-ray positron and negatron spectra between 50 and 800 MV (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: A balloon-borne spark chamber magnetic spectrometer has been used to measure the spectra of cosmic-ray positrons and negatrons at energies between 50 and 800 MV. The data reported here were obtained during two flights from Fort Churchill, Manitoba, in July 1972. The present results indicate that the dominance of negatrons from primary sources, found in earlier experiments above 200 MV, extends down to at least 50 MV. Solar modulation of the positron component is found to be consistent with that of the total electron spectrum, assuming that the positron component is entirely attributable to collisions between cosmic-ray nuclei and the interstellar gas.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 198; June 1
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  • 10
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    The light curve of a transient X-ray source (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: The Ariel-5 satellite has monitored the X-ray light curve of A1524-62 almost continuously from 40 days prior to maximum light until its disappearance below the effective experimental sensitivity. The source exhibited maximum light on Dec. 4, 1974, at a level of 0.9 the apparent magnitude of the Crab Nebula in the energy band 3-6 keV. Although similar to previously reported transient sources with a decay time constant of about 2 months, the source exhibited an extended, variable preflare on-state of about 1 month at a level of greater than 0.1 maximum light. The four bright (greater than 0.2 of the Crab Nebula) transient sources observed during the first half-year of Ariel-5 operation are indicative of a galactic disk distribution, a luminosity at maximum in excess of 10 to the 37-th power ergs/sec, a frequency of occurrence which may be as high as 100/yr, and a median decay time which is less than 1 month.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal; 201; Nov. 1
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