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  • 1
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischinger, P J -- Blevins, C S -- Dunlop, N M -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Genes, Viral ; Glycoproteins/immunology ; Leukemia, Experimental/*microbiology ; Lymphoma/*microbiology ; Mice ; Mice, Inbred BALB C/microbiology ; Mice, Inbred Strains/microbiology ; Moloney murine leukemia virus/classification/*genetics/immunology ; Recombination, Genetic ; Species Specificity ; Viral Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Phagocytosis in the retinal pigment epithelium of the RCS rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: The retinal pigment epithelium of RCS rats, previously thought not to phagocytize photoreceptor outer segments, exhibited a peak of phagocytosis in vivo when animals were kept under conditions of cyclic lighting (12 hours of darkness and 12 hours of light). The peak occurred at 1 hour after the onset of light, with maximum and minimum levels of phagocytosis averaging about 5 percent of that found in the pigment epithelium of Osborn-Mendel rats used as a control. Eyecups that were obtained from Osborn-Mendel rats and maintained for up to 3 hours in organ culture demonstrated levels of phagocytosis that were sevenfold greater than those of unincubated controls. Likewise a tenfold increase occurred in incubated as opposed to unicubated RCS eyes, raising the possibility that phagocytosis could be experimentally stimulated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, A I -- O'Brien, P J -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1023-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567376" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Count ; Circadian Rhythm ; Organ Culture Techniques ; Phagocytes/ultrastructure ; *Phagocytosis ; Pigment Epithelium of Eye/*metabolism/ultrastructure ; Rats ; Rats, Inbred Strains/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Brain endolases as specific markers of neuronal and glial cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmechel, D -- Marangos, P J -- Zis, A P -- Brightman, M -- Goodwin, F K -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*enzymology ; Cross Reactions ; Immunoenzyme Techniques ; Isoenzymes/*metabolism ; Liver/enzymology ; Neuroglia/*enzymology ; Neurons/*enzymology ; Phosphopyruvate Hydratase/immunology/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Regulative interactions between cells from different imaginal disks of Drosophila melanogaster (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: The regulative behavior of cells from the imaginal wing disk of Drosophila melanogaster can be modified by interaction with cells from different disk types. Both thoracic and nonthoracic disks are able to interact, but there are major differences in the effectiveness of interaction. The finding lends experimental support to the idea that cells in different fields within the same organism use the same mechanism for specifying positional information. A similar conclusion has been reached by Wilcox and Smith based on studies of the mutation wingless.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bryant, P J -- Adler, P N -- Duranceau, C -- Fain, M J -- Glenn, S -- Hsei, B -- James, A A -- Littlefield, C L -- Reinhardt, C A -- Strub, S -- Schneiderman, H A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):928-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/98843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/radiation effects ; Drosophila melanogaster/cytology/*growth & development ; Gamma Rays ; Regeneration ; Wings, Animal/cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Subfornical organ efferents to neural systems for control of body water (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: The subfornical organ, a circumventricular structure of the central nervous system, has efferent neural projections to sites within the brain known to be involved in drinking behavior and secretion of antidiuretic hormone. By using anterograde tracing techniques, it is shown that the subfornical organ projects to the nucleus medians of the medial preoptic area, to the organum vasculosum of the lamina terminalis, and to the supraoptic nuclei bilaterally. Its efferent connectivity is confirmed by retrograde transport of horseradish peroxidase. The organum vasculosum of the lamina terminalis, another circumventricular organ and a suspected receptor site for angiotensin II, is involved in the circuitry of the subfornical organ and also has an efferent projection to the supraoptic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miselis, R R -- Shapiro, R E -- Hand, P J -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1022-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472723" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cerebral Ventricles/*cytology ; Drinking Behavior/physiology ; Efferent Pathways/physiology ; Male ; Neurosecretory Systems/*physiology ; Preoptic Area/cytology ; Rats ; Subfornical Organ/cytology/*physiology ; Supraoptic Nucleus/cytology ; *Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Chemical carcinogens: estimating the risk (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reitz, R H -- Quast, J F -- Watanabe, P G -- Gehring, P J -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1206-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotransformation ; *Carcinogens ; Humans ; Risk ; Species Specificity ; Vinyl Chloride/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Evidence for a 17d periodicity from Cyg X-3 (1976)
    In:  CASI
    Details
    Publication Date: 2006-04-18
    Description: Data which indicate a periodicity of 17d from Cyg X-3 are reviewed. The data are taken from the Ariel 5 satellite All-Sky Monitor and the Sky Survey Experiment.
    Keywords: ASTROPHYSICS
    Type: X-ray Binaries; p 245-253
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    NASA TECHNICAL REPORTS
  • 9
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    Her X-1 spectral evidence for a strong magnetic field (1976)
    In:  CASI
    Details
    Publication Date: 2006-04-18
    Description: The steep high energy cutoff observed in the spectrum for Her X-1 is analyzed in terms of the severely modified Thomson scattering that dominates the radiative transfer in a highly magnetized plasma near the surface of a neutron star. The data are shown to indicate a field of about 10 to the 13th power G near the magnetic poles and the stopping of accreting matter by nuclear collisions in the neighboring plasma.
    Keywords: ASTROPHYSICS
    Type: X-ray Binaries; p 113-118
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    NASA TECHNICAL REPORTS
  • 10
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    Mass determination for the X-ray binary system Vela X-1 (equals 3U 0900-40) (1976)
    In:  CASI
    Details
    Publication Date: 2006-04-18
    Description: From a radial velocity study of lines of He I and the heavier ions of HD 77581 (=Vela X-1), orbital elements for this X-ray binary system are derived. Together with the orbital elements given by Rappaport and McClintock from X-ray pulsar results, this enables determination of masses for both the X-ray and the early type supergiant component.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center X-ray Binaries; p 643-657
    Format: text
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    NASA TECHNICAL REPORTS
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