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  • Animals  (134)
  • SPACECRAFT DESIGN, TESTING AND PERFORMANCE  (130)
  • 1975-1979  (264)
  • 1
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    Sex pheromone of the tsetse fly: isolation, identification, and synthesis of contact aphrodisiacs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-25
    Description: Sex pheromones isolated from the cuticle of the female tsetse fly, Glossina morsitans morsitans Westwood, release mating behavior in the male fly at ultrashort range or upon contact with baited decoys. Three active components were identified as 15,19-dimethylheptatriacontane, 17,21-dimethylheptatriacontane, and 15,19,23-trimethylheptatriacontane. Chemical and biological comparisons show that the natural and synthetic compounds are identical.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carlson, D A -- Langley, P A -- Huyton, P -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):750-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Male ; Pheromones/*isolation & purification ; Sex Attractants/chemical synthesis/*isolation & purification/pharmacology ; Sexual Behavior, Animal/drug effects ; Tsetse Flies/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Chicken gizzard: relation between calcium-activated phosphorylation and contraction (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Of the proteins in mechanically disrupted chicken gizzard fibers (no functional sarcolemma) only the 20,000-dalton light chains of myosin underwent large Ca2+-and Sr2+-dependent changes in phosphorylation. Phosphorylation closely corresponded with the Ca2+- and Sr2+-activated tensions. Adenosine 5'-O (3'-thiotriphosphate) only in the presence of Ca2+ induced irreversible Ca2+-insensitive activation of tension and thiophosphorylation of the 20,000-dalton light chains, and blocked incorporation of 32P from [gamma-32P]adenosine triphosphate into the myosin light chains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoar, P E -- Kerrick, W G -- Cassidy, P S -- New York, N.Y. -- Science. 1979 May 4;204(4392):503-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432654" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*pharmacology ; Chickens ; Gizzard/*physiology ; In Vitro Techniques ; Molecular Weight ; Muscle Contraction/*drug effects ; Muscle, Smooth/*physiology ; Myosins/*metabolism ; Phosphorylation ; Protein Kinases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Formation of mutagens in beef and beef extract during cooking (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: Mutagens, distinguishable from benzo[a]pyrene and from mutagenic amino acid and protein pyrolysis products, are formed when ground beef is cooked in a home hamburger cooking appliance or when beef stock is concentrated, by boiling, to a paste known commercially as beef extract. "Well-done" hamburgers contain about 0.14 part per million of the mutagens, and beef bouillon cubes which contain beef extract about 0.1 part per million. Since such mutagens may be potentially carcionogenic and are formed during ordinary cooking procedures, their occurrence raises questions about possible risks to human health.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Commoner, B -- Vithayathil, A J -- Dolara, P -- Nair, S -- Madyastha, P -- Cuca, G C -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):913-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567374" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzopyrenes ; Cattle ; *Hot Temperature ; Isoelectric Point ; Meat/*adverse effects ; Meat Products/adverse effects ; *Mutagens/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Insulin labeled with iodine-125 binds to receptors on isolated rat hepatocytes. At low temperatures initial binding is restricted to the plasma membrane as detected by direct quantitative autoradiographic analysis with the electron microscope. With increasing time and temperature of incubation there is a systematic and progressive translocation of autoradiographic grains to a highly limited area of the cell periphery representing no more than 15% of the radius of the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorden, P -- Carpentier, J L -- Freychet, P -- LeCam, A -- Orci, L -- New York, N.Y. -- Science. 1978 May 19;200(4343):782-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644321" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism ; Endocytosis ; Insulin/*metabolism ; Kinetics ; Liver/*metabolism/ultrastructure ; Lymphocytes/metabolism ; Lysosomes/metabolism ; Molecular Weight ; Rats ; Receptor, Insulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Immunity to antigens associated with primate C-type oncoviruses in pregnant women (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)--infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV--SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirsch, M S -- Kelly, A P -- Chapin, D S -- Fuller, T C -- Black, P H -- Kurth, R -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1337-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204010" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/*analysis ; *Antigens, Viral ; Female ; Humans ; *Immunity, Cellular ; Papio/microbiology ; *Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Retroviridae/*immunology ; Sarcoma Virus, Woolly Monkey/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    The LDH virus: an interfering biological contaminant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- Spackman, D H -- Santisteban, G A -- Dalldorf, G -- Hellstrom, I -- Hellstrom, K E -- Lance, E M -- Rowson, K E -- Mahy, B W -- Alexander, P -- Stock, C C -- Sjogren, H O -- Hollander, V P -- Horzinek, M C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/263259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Lactate dehydrogenase-elevating virus ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/microbiology ; Virus Diseases/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Tricyclic antidepressants vary in their capacity to cause psychomotor activation, to relieve agitated depressive states, and to cause sedation and hypotension. We have quantified relative potencies of tricyclic antidepressants in competing for the binding of 3H-labeled WB-4101 to alpha-noradrenergic receptor sites in rat brain membranes. Affinities of tricyclic drugs for alpha-noradrenergic receptor sites in the brain correlate well with the capacity of these agents to relieve psychomotor agitation and to induce sedation and hypotension; these affinities also correlate inversely with tendencies to elicit psychomotor activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉U'Prichard, D C -- Greenberg, D A -- Sheehan, P P -- Snyder, S H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):197-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents, Tricyclic/*metabolism/therapeutic use ; Binding, Competitive ; Brain/*metabolism ; Humans ; Hypotension/chemically induced ; Psychomotor Agitation/*drug therapy ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, alpha/*metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Brain endolases as specific markers of neuronal and glial cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmechel, D -- Marangos, P J -- Zis, A P -- Brightman, M -- Goodwin, F K -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*enzymology ; Cross Reactions ; Immunoenzyme Techniques ; Isoenzymes/*metabolism ; Liver/enzymology ; Neuroglia/*enzymology ; Neurons/*enzymology ; Phosphopyruvate Hydratase/immunology/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Regulative interactions between cells from different imaginal disks of Drosophila melanogaster (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-08
    Description: The regulative behavior of cells from the imaginal wing disk of Drosophila melanogaster can be modified by interaction with cells from different disk types. Both thoracic and nonthoracic disks are able to interact, but there are major differences in the effectiveness of interaction. The finding lends experimental support to the idea that cells in different fields within the same organism use the same mechanism for specifying positional information. A similar conclusion has been reached by Wilcox and Smith based on studies of the mutation wingless.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bryant, P J -- Adler, P N -- Duranceau, C -- Fain, M J -- Glenn, S -- Hsei, B -- James, A A -- Littlefield, C L -- Reinhardt, C A -- Strub, S -- Schneiderman, H A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):928-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/98843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/radiation effects ; Drosophila melanogaster/cytology/*growth & development ; Gamma Rays ; Regeneration ; Wings, Animal/cytology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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