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Digitale Medien

Untersuchung chromatographischer Racemattrennungen, VII Präparative Trennversuche an optisch aktiven Polyamiden (1977)

Schwanghart, Anne-Dore ; Backmann, Wolfgang ; Blaschke, Gottfried

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 110 (1977), S. 778-787

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ISSN: 0009-2940

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: Investigation of Chromatographic Resolutions of Racemates, VII Preparative Resolutions on Optically Active PolyamidesThe optically active polyamides 1, 2a and b enable optical resolutions of racemates of α-substituted 2-phenylacetamides (3a-g), mandelic acid derivatives (4a-c), N-substituted acetamides (5a-d. 6, 7), N-acylamino acid esters (8a-h), and benzoin derivatives (9a-c). The amide 5c was resolved on a preparative scale yielding both optically pure enantiomers.

Notizen: Die optisch aktiven Polyamide 1, 2a und b trennen Racemate von α-substituierten 2-Phenylacetamiden (3a-g), Mandelsäurederivaten (4a-c), N-substituierten Acetamiden (5a-d, 6, 7), N-Acylaminosäureestern (8a-h) und Benzoinderivaten (9a-c). Das Amid 5c wurde im präparativen Maßstab in beide optisch reinen Enantiomeren aufgetrennt.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cber.19771100242

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Digitale Medien

Untersuchung chromatographischer Racemattrennungen, VI. Polymere Aminosäurederivate als optisch aktive Adsorbentien (1976)

Blaschke, Gottfried ; Schwanghart, Anne-Dore

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 109 (1976), S. 1967-1975

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ISSN: 0009-2940

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: Investigation of Chromatographic Resolutions of Racemates, VI. Polymeric Amino Acid Derivatives as Optically Active AdsorbensStarting with optically active amino acids, the polyacrylamides 3a-h, 5a-d and 6a, b the polymethacrylamides 8a-c and the polyacrylic ester 6f were synthesized. The separation efficiencies of these polymers were determined by chromatography of racemic mandelic acid and mandelamide, respectively. The best separations of the enantiomers of both racemates were observed on the phenylalanine derivatives 3e and 5a.

Notizen: Die Polyacrylamide 3a-h, 5a-d und 6a, b die Polymethacrylamide 8a-c und der Polyacrylsäureester 6f wurden aus optisch aktiven Aminosäurederivaten hergestellt und auf ihre Trennwirkung durch Chromatographie racem. Mandelsäure sowie racem. Mandelamids geprüft. Die beste Trennung der Enantiomeren beider Racemate wurde an den Phenylalaninderivaten 3e und 5a beobachtet.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cber.19761090601

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Chloroquin-Enantiomere durch chromatographische Racemattrennung und Synthese (1978)

Blaschke, Gottfried ; Kraft, Horst-Peter ; Schwanghart, Anne-Dore

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 2732-2734

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ISSN: 0009-2940

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Chloroquine Enantiomers by Chromatographic Resolution and SynthesisThe chromatographic resolution of the antimalarial drug chloroquine (1) on an optically active polyamide is described. The results reveal that the optical purity of chloroquine formerly resolved with d-bromocamphorsulfonic acid was 12% only. A facile synthesis of the enantiomers via the optically active diamine 4 is given.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cber.19781110730

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An absolute method for the determination of the persistence length of native DNA from electron micrographs (1979)

Frontali, C. ; Dore, E. ; Ferrauto, A. ; [weitere]

New York : Wiley-Blackwell

Biopolymers 18 (1979), S. 1353-1373

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ISSN: 0006-3525

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Information on spatial correlation in the tangent direction along electron microscope images of filamentous molecule is shown to be obtainable by the analysis of statistical fluctuations in curvature, yielding an absolute measure of the persistence parameter amicro. The relationship of amicro, a local, microscopic parameter, to the persistence length introduced by Kratky and Porod is discussed. The hypotheses underlying the assumed theoretical model concern (1) the shape of the angle distribution, assumed to be Gaussian; (2) the passage from a three- to a two-dimensional situation, which is supposed to occur by deformation of the flexible chain in a manner that preserves the memory of the spatial correlation in orientation (except for the blocking of one degree of freedom); and (3) the adsorption conditions, which should meet the equilibrium requirement as closely as possible. The analytical method has been checked on computer simulated “Gaussian” molecules: the study of the simulated sample was essential in solving the problems connected with minimum statistics requirements and the effect of the reading error. Experimental images obtained for T2 DNA fragments at different ionic strengths by Kleinschmidt's adsorption technique have been analyzed by means of an automatic flying spot digitizer, the “Precision Encoder and Pattern Recognition.” The results show that adsorbed molecules do in fact “remember” the rigidity they possessed in solution and that the Gaussian hypothesis is well verified. Consequently, the slopes of log cosθ(l) or θ2(l) may be used indifferently in the estimate of amicro. The dependence of this parameter on ionic strength in the range explored shows the expected behavior.

Zusätzliches Material: 11 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bip.1979.360180604

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