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  • Springer  (15)
  • American Institute of Physics (AIP)
  • PANGAEA
  • Taylor & Francis
  • 1975-1979  (15)
Collection
Publisher
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 65 (1978), S. 389-390 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 31 (1975), S. 343-344 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 2–4 h nach Hypophysektomie erhöht Noradrenalin den Sauerstoffverbrauch wie bei Kontrollratten, 7 Tage nach der Entfernung der Hypophyse ist jedoch diese Wirkung des Noradrenalin aufgehoben. Die CO2-Abgabe verhält sich qualitativ wie der Sauerstoffverbrauch.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Probability theory and related fields 50 (1979), S. 179-204 
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary For n=1,2, ... let P n be a set of probability measures on the measurable space (X, A) containing a fixed nulldistribution P 0. We study approximations of P n n ={P n : P∈P n } for large n. Degeneracy is avoided by postulating that (1) no P n can be distinguished from P 0 n with probability almost 1 (P∈P n ); (2) events of small P 0-probability contain little information. The second condition turns out to be equivalent to the existence of nondegenerating multinomial approximations to P n n obtained from partitions of the sample space X. In particular we consider the case that (X, A) is the real axis endowed with the field of Borel sets and that dP/dP 0 (x) are monotonic functions of x. If (1) and (2) are satisfied, the family P n n can be approximated by a multinomial family obtained from an interval partition of the line which depends on the accuracy of approximation, but not on n.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Mineralium deposita 14 (1979), S. 375-380 
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 42 (1978), S. 9-14 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nucleus anomaly test in Chinese hamsters and in rats treated with isoniazid (INH) was carried out according to a standard protocol in two different laboratories. These comprised both short-term studies, in which the tests were performed on animals killed 6, 12, 24, 36, or 48 h after the second of two consecutive doses of 5, 25, or 125 mg/kg INH given at an interval of 24 h, and long-term studies in animals treated with 25 mg/kg INH thrice weekly for 12 weeks. As a rule, each group consisted of at least four animals, and 1000 cells from each animal were examined. In one of the laboratories, a slight, but statistically significant increase in the incidence of nuclear anomalies was observed in two experiments on animals sacrificed 24 h after treatment; in the majority of cases, however, the investigations yielded negative results. Two out of three long-term studies revealed a slight, but statistically significant increase in the incidence of nuclear anomalies.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogenetic investigations in bone marrow from animals treated with isoniazid (INH) were performed in seven different laboratories according to a standard protocol. The experiments were carried out in the Chinese hamster, the mouse, and the rat. In short-term studies INH was administered twice at an interval of 24 h in doses of 5, 25, and 125 mg/kg, and the animals were sacrificed 6, 12, 24, and 48 h after the second dose. In long-term studies doses of 25 and 125 mg/kg were administered thrice weekly for 12 weeks. As a rule, each group consisted of at least four animals, and 100 metaphases per animal were counted. Statistical analysis of the data showed that the incidence of chromosomal aberrations including gaps lay in the critical range for two groups in one laboratory and was significantly higher than in the control in three groups in another of the seven laboratories. From the results of both the short-term and the long-term studies in all laboratories, however, it may be concluded, that isoniazid does not induce gross chromosomal aberrations.
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3×125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3–16 mg/kg).
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The zinc content of the liver and the thigh muscle of the rat were measured by means of atomic absorption spectrophotometry under different conditions: standard diet, carbohydrate diet, an experimental dystrophy model and its recovery period. The influence of a parental mineral substitution on the whole body and the organ weight was studied. Carbohydrate diet caused a lower rise of the whole body weight, a decrease of the zinc content of the liver and an increase of the zinc content of the thigh muscle. In dystrophy model, the liver weight decreased to one fifth of the controls. The zinc concentration of the liver increased markedly, the zinc content of the whole liver is equal to that of control animals. The thigh muscle showed an increase of the zinc content, too. The parenteral mineral application had no effect upon the whole body weight and the organ weights. Little influences on the zinc content of the skeletal muscle were seen. The zinc content of parenchymatous organs varies markedly, and it is influenced by diets and disease. In the dystrophy model, zinc is concentrated in atrophic organs in order to protect the organism against zinc deficiency.
    Notes: Zusammenfassung Der Zinkgehalt der Leber und der Oberschenkelmuskulatur der Ratte wurde nach einseitiger Kohlenhydratdiät, einem experimentellen Dystrophiemodell sowie nach dessen Erholungsphase untersucht. Es wurde der Einfluß einer parenteralen Substitution organischer bzw. anorganischer Mineralverbindungen auf das Gesamtkörpergewicht, das Organgewicht und die Organ-Zink-Konzentration verfolgt. Die einseitige Diät führt zu einer retardierten Entwicklung der Versuchstiere und zu einer Umverteilung von Zink aus der Leber in die Skeletmuskulatur. Das Dystrophiemodell reduziert das Lebergewicht durch Atrophie der Hepatozyten auf ein Fünftel des Normalgewichts. Die relative Zinkkonzentration steigt dabei so an, daß der Gesamtzinkgehalt in der Leber unverändert bleibt. In geringerem Ausmaß konzentriert die Skeletmuskulatur Zink in den atrophischen Muskelfasern. In der Erholungsphase hat die parenterale Gabe organischer oder anorganischer Metallverbindungen keinen Einfluß auf das Körpergewicht, das Organgewicht und m. E. den Zinkgehalt der Organe. Die Zinkkonzentrationen der parenchymatösen Organe sind somit Variable, die durch Stoffwechseleinflüsse und Krankheit beeinflußt werden.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Genetica 46 (1976), S. 287-296 
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Plants homozygous for an interchange in the long arms of chromosomes 3 and 5 were selected from the progeny of translocated heterozygotes through mitotic chromosome analysis. While a deficit of translocated homozygotes was observed in these segregating families, an increase in the proportion of normal plants was obtained. The translocated homozygotes showed a bushy, dwarfed and weak form coupled with nearly complete sterility. Meiosis turned out to be normal except for the presence of anaphase bridges that occurred in about 10 percent of the pollen mother cells. However, vegetative and floral buds degenerated in the majority of cases before pods developed. In mitosis, anaphase bridges were observed. Their frequency was 30 percent and they were formed by only one of the exchanged chromosomes. Such bridges are considered a consequence of the so-called point errors, which are suggested as the main cause of developmental disturbances.
    Type of Medium: Electronic Resource
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