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  • Inorganic Chemistry  (322)
  • Life and Medical Sciences  (188)
  • 1975-1979  (294)
  • 1950-1954  (45)
  • 1930-1934  (80)
  • 1920-1924  (48)
  • 1905-1909  (43)
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  • 1
    Electronic Resource
    Electronic Resource
    Partial regeneration of the above-elbow amputated rat forelimb. II. Electrical and mechanical facilitationSupported by the Veterans Administration Medical Research Program Project Number 7004-04 and a Medical Investigatorship Award to P.P. (1979)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 159 (1979), S. 439-451 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This investigation was undertaken to examine the observations of Becker ('72) pertaining to the electrical facilitation of partial limb regenerative responses by means of Ag-Pt wire couples applied to the limb stumps of young, forelimb-amputated white rats. Additionally, in order to examine the possible role of mechanical effects of such device implantations, we have employed uncoupled devices delivering no current or potential difference. In the present experiments, in response to coupled device implantation, cartilage and bone were actively formed in the vicinity of the Pt electrode tip. These tissues contributed to the lengthwise extension of the limb and to the partial restoration of the distal humeral extremity. In limbs bearing the uncoupled electrical devices, qualitatively similar responses were noted, but osteogenesis was diminished in extent compared to that seen in limbs bearing the active or coupled devices. It is therefore necessary to consider the role of mechanical factors in the elicitation of the observed regenerative responses. Myogenesis was enhanced in electrically stimulated limbs, but not in those rats bearing uncoupled devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051590309
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  • 2
    Electronic Resource
    Electronic Resource
    Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 97 (1978), S. 371-380 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Early passage mouse embryo fibroblasts, mouse 3T3 cell lines, and early passage diploid human fibroblasts grew to higher cell densities in tissue culture medium supplemented with serum than in medium supplemented with defibrinogenated platelet-poor plasma (PPP). Unlike the mouse cells, the human fibroblasts displayed this differential growth response only in the presence of hypophysiologic concentrations of calcium. The addition of heat-treated extracts of human platelets to PPP-supplemented medium stimulated the replication of both the normal mouse cells and early passage human embryo fibroblasts.Human or mouse fibroblasts transformed by either retroviruses or by SV40, including SV40 infected “serum revertants” and “flat transformants,” grew to equal cell densities in medium supplemented with either serum or PPP. Infection of Balb/c-3T3 cells with SV40 rapidly induced them to grow in PPP-supplemented medium demonstrating that the ability of SV40-transformed cell lines to proliferate in PPP-supplemented medium does not arise from the cell culture selection procedures usually employed to obtain stable virus-transformed cell lines. 3T3 cells infected but not transformed by retroviruses do not replicate in PPP-supplemented medium demonstrating that reduction of the growth requirement for the platelet growth factor(s) by retroviruses is a transformation-specific response. Cell cultures that did not proliferate well in PPP-supplemented medium did not form tumors when inoculated into athymic nude mice. Many, although not all, of the lines which grew well in PPP medium were tumorigenic in nude mice. Together, these findings indicate that: (1) normal fibroblast-like cells display a growth requirement for factor(s) present in serum but not found in PPP; (2) this serum specific growth factor is derived from platelets; (3) a primary response to viral transforming genes is a reduction in the growth requirement for these platelet-derived factors; and (4) cells that have a reduced requirement for the platelet-derived growth factor are often tumorigenic.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040970312
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  • 3
    Electronic Resource
    Electronic Resource
    Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: Analysis using platelet-derived growth factor and platelet-poor plasma (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 99 (1979), S. 395-405 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Much controversy regarding the relationship between nutrients and serum in regulation of cell growth can be reconciled by recognizing that serum contains multiple factors which regulate different events in the cell cycle. Serum was fractioned into a platelet-derived growth factor (PDGF), which induces cells to become competent to synthesize DNA, and plasma which allows competent cells to traverse G0/G1 and enter the S phase. Nutrients are not required for the cellular response to PDGF; however amino acids are required for plasma to promote the entry of PDGF-treated, competent cells into S phase. The nutrient independent, PDGF-modulated, growth regulatory event (competence) is located 12 hours prior to the G1/S phase boundary in quiescent, density-arrested Balb/c-3T3 cells. The nutrient dependent, plasma-modulated event is located six hours prior to the G1/S phase boundary and corresponds in time to a plasma dependent growth arrest point. Moreover, plasma controls the concentration of amino acids required for DNA synthesis. Infection of density-arrested Balb/c-3T3 cells with SV40 overrides both the nutrient independent and the nutrient dependent growth regulatory events.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040990314
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  • 4
    Electronic Resource
    Electronic Resource
    The tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 100 (1979), S. 413-424 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Stimulation of Balb/c-3T3 cell growth by TPA requires factors found in serum. We examined the interaction between TPA and serum growth factors in the stimulation of cell growth. The number of cells synthesizing DNA (incorporating 3H-thymidine) within 24 to 30 hours after the addition of TPA and the growth factors to density-inhibited Balb/c-3T3 cultures in serum-free medium was determined by autoradiography. With no additions or with TPA (30-300 ng/ml) alone, only 3-7% of cells synthesized DNA. However, TPA synergistically promoted DNA synthesis in combination with each of the defined serum growth fractions, platelet derived growth factor and platelet poor plasma. TPA also synergistically promoted DNA synthesis in combination with purified growth factors including fibroblast growth factor, insulin (10-6-10-5 M), and epidermal growth factor. In all conditions, TPA enhancement of DNA synthesis also resulted in an increase in cell number. Because TPA synergistically enhanced the activity of each growth factor tested, it did not act identically to any of the growth factors.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041000305
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  • 5
    Electronic Resource
    Electronic Resource
    The characterization of SV40-transformed cell lines derived from mouse teratocarcinoma: Growth properties and differentiated characteristicsA portion of this work was presented at the Conference on “Regulation of Gene Expression in Development and Neoplasia” which was published in Cancer Research, 36, 4217-4223, 1976. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 93 (1977), S. 269-276 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse teratocarcinoma cells derived from embryoid bodies of 129SVsl mice were cultured in vitro to permit their differentiation. These cells were then infected with simiam virus 40 (SV40) and 31 cloned cell lines (SVTER) were derived from these cultures. All 31 SVTER cell lines contained the SV40 tumor (T) antigen and grew as permanent lines in culture. Mock-infected embryoid body cultures did not give rise to permanent cell lines. The morphology of each SVTER cell line was distinct and did not change during successive subclonings.The growth properties and tumorigenic potential of all 31 SVTER cell lines were investigated. None of these lines produced tumors in 129SVsl mice. Each cell line was tested for its ability to (1) grow in medium containing 1% serum, (2) plate on a cell monolayer, and (3) form clones in methocel suspension. Only three of the SVTER cell lines were transformed with respect to all three of these criteria. Most of these cell lines were minimal transformation.The SVTER cell lines were tested for creatine phosphokinase (CPK), an enzyme activity characteristic of mouse brain and muscle tissue, and the protease, plasminogen activator (PA) which is found in embryoid bodies and several differentiated cell types. Some of the SVTER cell lines contained high levels of CPK, while others had high levels of PA and a third group of cells contained neither enzyme activity. No SVTER cell line was found with high levels of both these enzyme activities. This result suggests that mutually exclusive sets of genes are expressed in these cells as might be expected from the distinct tissue distribution of the two enzyme activities studied. These SVTER cell lines may be useful in reconstructing developmental pathways of differentiating teratomas in vitro.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040930212
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  • 6
    Electronic Resource
    Electronic Resource
    Die Kristallstruktur des Thallium(I)-hexaiodomercurat(II), Tl4Hgl6Professor Walter Rüdorff zum 70. Geburtstage am 3. Oktober 1979 gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 456 (1979), S. 29-40 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Crystal Structure of Thallium(I) Hexaiodomercurate(II), Tl4HgI6In the structure of the tetragonal Tl4HgI6 (a = 944.6 pm, c = 926.0 pm, Z = 2, space group P 4/mnc) isolated, in c-direction compressed HgI6 octahedra are situated. The mercury atoms are disordered; they occupy statistically 4 positions in the equatorial plane of the octahedra in such a manner that strongly deformed HgI4 tetrahedra are produced. The thallium atoms are eightfold coordinated like a bicapped trigonal prism. The relationship between the Tl4HgI6 structure and the cubical K2PtCl6 type will be discussed.
    Notes: In der Struktur des tetragonalen Tl4HgI6 (a = 944,6 pm, c = 926,0 pm, Z = 2, Raumgruppe P 4/mnc) liegen isolierte, in Richtung der c-Achse gestauchte HgI6-Oktaeder vor. Die Quecksilberatome sind fehlgeordnet; sie besetzen statistisch 4 Positionen in der Äquatorebene der Oktaeder derart, daß stark verzerrte HgI4-Tetraeder entstehen. Die Thallium-Atome sind achtfach in Form eines bicapped trigonalen Prismas koordiniert. Die Beziehungen der Tl4HgI6-Struktur zum kubischen K2PtCl6-Typ werden diskutiert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794560103
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  • 7
    Electronic Resource
    Electronic Resource
    Organocobalt Cluster Compounds. 26. Synthesis of Methylidynetricobalt Nonacarbonyl complexes containing mercapto substituentsProfessor Kurt Issleib zum 60. Geburtstage gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 458 (1979), S. 267-272 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Organocobalt-Clusterverbindungen. 26. Die Darstellung von Mercaptosubstituenten enthaltenden Methylidyntricobaltnonacarbonyl-KomplexenDie Umsetzung von Bromo- und Chloromethylidyntricobaltnonacarbonyl, XCCo3(CO)9 (X = Br, Cl) mit Zinndimethylbis(alkylmercaptiden), (CH3)2Sn(SR)2 in Toluol unter Rückfluß in 20-30 min stellt eine gute Methode zur Herstellung von schwefelsubstituierten Methylidyntricobaltnonacarbonylkomplexen des Typs RSCCo3(CO)9 (R = Alkyl, Aryl, Acetyl, Benzoyl) dar. Ebenfalls effektiv, aber weniger praktisch waren Trimethylzinnalkylmercaptide und Quecksilber-bis(ethylmercaptid).
    Notes: The reaction of bromo- and chloromethylidynetricobalt nonacarbonyl, XCCo3(CO)9 (X = Br, Cl) with dimethyltin bis (alkyl mercaptides), (CH3)2Sn(SR)2, in toluene solution at reflux for 20-30 min provides a useful procedure for the preparation of sulfur-substituted methylidynetricobalt nonacarbonyl complexes of type RSCCo3(CO)9 (R = alkyl, aryl, acetyl, benzoyl). Also effective, but less practical, in such applications were trimethyltin alkylmercaptides and mercury bis (ethyl mercaptide).
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794580136
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  • 8
    Electronic Resource
    Electronic Resource
    29Si-NMR-Spektroskopie an Silicatlösungen. II. Zur Abhängigkeit der Struktur der Silicatanionen in wäßrigen Natriumsilicatlösungen vom Na : Si-Verhältnis (1975)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 418 (1975), S. 17-28 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: 29Si-NMR Spectroscopy of Silicate Solutions. II. On the Dependence of the Structure of Silicate Anions in Water Solutions from the Na : Si RatioThe 29Si-FT-NMR spectra of 13 sodiumsilicate solutions with different Na:Si ratios are investigated with regard to the structure of the silicate anions in the solutions. The 5 typical building units (Monosilicate, end-, middle-, branching and crosslinking groups) show characteristic and non overlapping ranges of the 29Si chemical shift with many signals splittings caused by different neighbouring group effects. The relative intensities of the signals give informations on the concentrations and the equilibrium of condensation of the silicate anions in dependence of the Na:Si ratio. It is shown, that many types of anions with different degree of condensation coexist in an equilibrium, which is shiftet to the polymer silicate anions with high content of branching and crosslinking groups on the decrease of the Na:Si ratio.
    Notes: Die 29Si-FT-NMR-Spektren von 13 Natriumsilicatlösungen mit unterschiedlichem Na:Si-Verhältnis werden in Hinblick auf die Struktur der in den Lösungen auftretenden Silicatanionen untersucht. Für die 5 möglichen Baugruppen (Monosilicat, Endgruppen. Mittelgruppen, Verzweigungs- und Vernetzungsgruppen) lassen sich definierte Bereiche der 29Si-chemischen Verschiebung angeben, in denen durch Einfluß der weiteren strukturellen Umgebung i. a. zahlreiche Signalaufspaltungen beobachtet werden. Aus den relativen Intensitäten der Signale können Aussagen über die Konzentrationsverteilung und damit über das Kondensationsgleichgewicht der Silicatanionen in Abhängigkeit vom Na:Si-Verhältnis abgeleitet werden. Es zeigt sich, daß zahlreiche Anionentypen mit unterschiedlichem Kondensationsgrad nebeneinander in einem Gleichgewicht vorliegen, das sich mit fallendem Na:Si-Verhältnis stark auf die Seite höhermolekularer Silicatanionen mit hohem Gehalt an Verzweigungs- und Vernetzungsgruppen verschiebt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19754180103
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Kenntnis der Hydrate des Na2PHO3, Phasenbeziehungen und kristallographische Untersuchungen (1978)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 439 (1978), S. 265-274 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the Hydrates of Na2PHO3, Phase Relations and Crystallographic InvestigationsDehydration of Na2PHO3,5 H2O to the respective anhydrous salt was investigated by thermogravimetry and differential thermal analysis. In the course of dehydration an intermediate lower hydrate is formed, Na2PHO3,0.5 H2O. Single crystals of this phase were grown from solution. Na2PHO3,0.5 H2O is rhombohedral, space group R32, R3m or R3m, with a = 18.918(5) Å and α = 33.00(2)°. - The crystal structure of Na2PHO3,5 H2O was redetermined. The pentahydrate is orthorhomic, space group Pnm21, with a = 7.190(1), b = 6.447(1), c = 9.230(2) Å. The structure consists of layers of Na-coordinating polyhedra which share edges and vertices. The layers are connected to a threedimensional structure by hydrogen bonds of the water molecules.
    Notes: Die Dehydratisierung von NaaPHO3 · 5 H2O zum wasserfreien Salz wurde mit Thermogravimetrie und Differentialthermoanalyse untersucht. Die Entwässerung verläuft über die Stufe eines intermediären niederen Hydrates, Na2PHO3 · 0,5 H2O. Einkristalle des Hemihydrates konnten aus Lösung gezüchtet werden; es kristallisiert rhomboedrisch, Raumgruppe R32, R3m oder R3m, mit a = 18,918(5) ß und α = 33,00(2)°. - Die Kristallstruktur von Na2PHO3 · 5 H2O wurde neu bestimmt. Das Pentahydrat kristallisiert orthorhombisch, Raumgruppe Pnm21 mit a = 7,109(1), b = 6,447(1), c = 9,230(2) Å. Die Struktur ist aus Schichten von kanten- und eckenverknüpften Na-Koordinationspolyedern aufgebaut. Die Schichten werden durch Wasserstoffbrückenbindungen der Wassermoleküle zu einem dreidimensionalen Strukturverband verknüpft.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19784390132
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  • 10
    Electronic Resource
    Electronic Resource
    1,2,3-Butatrien durch Diels-Alder-Spaltung (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 1655-1658 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: 1,2,3-Butatrien durch Diels-Alder RetrogressionThe pyrolysis of 1 leads to indane (6), whereas 2,3, and 4 yield 1,2,3-butatriene (5) by a Diels-Alder-retrogression.
    Notes: Die Pyrolyse von 1 führt zu Indan (6), während 2,3 und 4 unter Diels-Alder-Spaltung zerfallen und 1,2,3-Butatrien (5) liefern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080534
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