Publication Date:
1982-08-13
Description:
The input-output properties of interneurons mediating spinal reflexes were investigated by extracellularly recording the response of interneurons to excitation from muscle receptors in the ankle extensor muscles of decerebrated, spinal cats. A population ofinterneurons in the intermediate region ofthe spinal cord is potently excited by increases in muscle force. Unlike the discharge of Golgi tendon organs, which accurately encodes moment-to-moment variations in the force of a single muscle, the discharge of these interneurons depends in a dynamic and usually nonlinear way on the force in several muscles. Powerful input from unidentified mechanoreceptors in muscle, presumably free nerve endings, is at least partly responsible for these properties. These force-sensitive interneurons are more likely to mediate clasp knife-type inhibition than simple negative force feedback.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleland, C L -- Rymer, W Z -- Edwards, F R -- 5T32GM07350/GM/NIGMS NIH HHS/ -- NS14959/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):652-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089586" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cats
;
Evoked Potentials
;
Golgi-Mazzoni Corpuscles/physiology
;
In Vitro Techniques
;
Interneurons/*physiology
;
Mechanoreceptors/physiology
;
Motor Neurons/physiology
;
Muscle Contraction
;
Muscles/innervation
;
*Proprioception
;
Reflex, Stretch
;
Spinal Cord/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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