Publication Date:
1981-05-08
Description:
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis is man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, M S -- Kovanen, P T -- Goldstein, J L -- HL-20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 8;212(4495):628-35.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6261329" target="_blank"〉PubMed〈/a〉
Keywords:
Arteriosclerosis/metabolism
;
Biological Transport
;
Cholesterol/*blood
;
Chylomicrons/metabolism
;
Dietary Fats/metabolism
;
Homeostasis
;
Humans
;
Hyperlipoproteinemia Type II/metabolism
;
Lipoproteins/*metabolism
;
Liver/*metabolism
;
Receptors, Cell Surface/metabolism/*physiology
;
Receptors, LDL
;
Receptors, Lipoprotein
;
Triglycerides/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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