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  • 1
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    Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: Nondeletion forms of hereditary persistence of fetal hemoglobin may result from regulatory disorders of globin gene expression. The defects in two such conditions were localized by demonstrating a tight genetic linkage between the disorders and polymorphic restriction endonuclease sites within the beta-like globin gene complex. In one instance, the defect probably occurred outside the region of DNA between the epsilon- and beta-globin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Old, J M -- Ayyub, H -- Wood, W G -- Clegg, J B -- Weatherall, D J -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):981-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186021" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Deletion ; DNA Restriction Enzymes ; Female ; Fetal Hemoglobin/*genetics ; Genetic Linkage ; Globins/genetics ; Humans ; Male ; Pedigree ; Polymorphism, Genetic ; Thalassemia/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Toxicant-disease-environment interactions associated with suppression of immune system, growth, and reproduction (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: The effects of marginal malnourishment , infections, and environmental chemicals on growth and reproductive success in Swiss-Webster white mice and wild deer mice were studied with fractional factorial designs. Interaction effects were discovered. For example, malnourished mice were more sensitive to virus exposure and environmental chemicals (a plant growth regulator or polychlorinated biphenyls). Since several commercial plant growth regulators also appear to suppress the immune system, these results cast doubt on the adequacy of current toxicity testing procedures in which factors are studied individually and not in combination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, W P -- Hinsdill, R -- Fairbrother, A -- Olson, L J -- Jaeger, J -- Yuill, T -- Bisgaard, S -- Hunter, W G -- Nolan, K -- 5-T32-ES07015/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):1014-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6426058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Wild ; Chlormequat/adverse effects ; Cyclophosphamide/adverse effects ; Encephalomyelitis, Venezuelan Equine/physiopathology ; Environmental Exposure ; Female ; Food Supply ; Growth/*drug effects ; Humans ; Immunity/*drug effects ; Mice ; Nutrition Disorders/physiopathology ; Peromyscus ; Polychlorinated Biphenyls/adverse effects ; Pregnancy ; Reproduction/*drug effects ; Water Supply
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Dioxin in soil: bioavailability after ingestion by rats and guinea pigs (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, E E -- Lucier, G W -- Rumbaugh, R C -- Albro, P W -- Harvan, D J -- Hass, J R -- Harris, M W -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695194" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/biosynthesis ; Biological Availability ; Body Weight/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Dioxins/*metabolism ; Eating ; Enzyme Induction ; Female ; Guinea Pigs ; Intestinal Absorption ; Liver/drug effects ; Male ; Microsomes, Liver/enzymology ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; *Soil Pollutants/toxicity ; Tetrachlorodibenzodioxin/*metabolism/toxicity ; Thymus Gland/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-13
    Description: The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity was suppressed by the opioid, but not the nonopioid, form of stress. This suppression was blocked by the opioid antagonist naltrexone. Similar suppression of natural killer activity was induced by high doses of morphine. These results suggest that endogenous opioid peptides mediate the suppressive effect of certain forms of stress on natural killer cell cytotoxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shavit, Y -- Lewis, J W -- Terman, G W -- Gale, R P -- Liebeskind, J C -- MH15795/MH/NIMH NIH HHS/ -- NS07628/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691146" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cytotoxicity, Immunologic/drug effects ; Dose-Response Relationship, Drug ; Endorphins/*physiology ; Female ; Killer Cells, Natural/*immunology ; Morphine/*pharmacology ; Naltrexone/pharmacology ; Rats ; Rats, Inbred F344 ; Stress, Physiological/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Metabolism of catechol estrogens by erythrocyte catechol-O methyltransferase (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bates, G W -- Jackson, E Jr -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1145.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268425" target="_blank"〉PubMed〈/a〉
    Keywords: Catechol O-Methyltransferase/*blood ; Erythrocytes/*enzymology ; Estrone/*analogs & derivatives ; Female ; Humans ; Hydroxyestrones/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Enhancement of sexual behavior in female rats by neonatal transplantation of brain tissue from males (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: Transplantation of preoptic tissue from male rat neonates into the preoptic area of female littermates increased masculine and feminine sexual behavior in the recipients during adulthood. This suggests that functional connections develop between the transplanted neural tissue and the host brain. A new intraparenchymal brain transplantation technique was used to achieve these results.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arendash, G W -- Gorski, R A -- HD-01182/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1276-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112132" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/physiology ; Animals ; Brain/*physiology ; Female ; Hypothalamus/*physiology ; Male ; Nerve Tissue/*transplantation ; Preoptic Area/*physiology ; Rats ; Sex Differentiation ; Sexual Behavior, Animal/*physiology ; Testosterone/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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