Publication Date:
1983-06-24
Description:
Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal lambda II protein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional lambda I protein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both lambda II- and lambda I-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent lambda isotypes may be coordinately regulated in immunoglobulin-secreting cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Milburn, G L -- Lynch, R G -- Granner, D K -- AM25295/AM/NIADDK NIH HHS/ -- CA28848/CA/NCI NIH HHS/ -- CA32275/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1389-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6222474" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line
;
*Gene Expression Regulation
;
Immunoglobulin Light Chains/genetics
;
Immunoglobulin lambda-Chains/genetics
;
Immunoglobulins/*genetics
;
Mice
;
Mice, Inbred BALB C
;
Plasmacytoma/genetics/immunology
;
RNA, Messenger/biosynthesis
;
T-Lymphocytes, Regulatory/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
