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  • Wiley-Blackwell  (7)
  • American Association for the Advancement of Science (AAAS)  (6)
  • 1980-1984  (12)
  • 1950-1954  (1)
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Keywords
Publisher
Years
Year
  • 1
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    Cost of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, C A -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):743.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17744376" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Funding more NIH research grants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-22
    Description: Because of the prospect of a serious decline in the nation's biomedical research capacity owing to diminished federal appropriations, temporary measures should be initiated promptly by the National Institutes of Health to preserve the stability of resources and diversity of research required for future productivity. It is recommended that the available funds be distributed in such a way as to permit some support for 50 percent of competing grant applications approved by the National Institutes of Health study sections. Measures proposed for consideration are a sliding scale for funding, a greater across-the-board reduction, a limit on support for an individual laboratory, and a review of indirect costs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandel, H G -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867712" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.)/organization & administration ; *Research Support as Topic/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-27
    Description: Amiloride inhibited the ouabain-sensitive rate of oxygen consumption (QO2) of a suspension of rabbit intact proximal tubules in the presence of different concentrations of extracellular sodium. Measurements of the ouabain-sensitive QO2 in the presence of nystatin, the tissue sodium and potassium contents of the tubules in suspension, and the sodium- and potassium-dependent adenosinetriphosphatase (Na,K-ATPase) activity of lysed tubule membranes indicated that the effect of amiloride was due to a direct inhibition of the Na,K-ATPase activity of the proximal tubule.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soltoff, S P -- Mandel, L J -- AM26816/AM/NIADDK NIH HHS/ -- GM29256/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302840" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Ion Channels/drug effects ; Kidney Tubules, Proximal/drug effects/*enzymology ; Nystatin/pharmacology ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Pyrazines/*pharmacology ; Rabbits ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Phase variation: evolution of a controlling element (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-19
    Description: Phase variation in bacteria is regulated by homologous recombination at a specific DNA site. This recombinational event causes the inversion of a 970-base-pair DNA sequence that includes the promoter necessary for transcription of a flagellar gene. The invertible segment is flanked by two sites that are necessary for the inversion and contains a gene (hin) whose product mediates the inversion event. The hin gene shows extensive homology with the TnpR gene carried on the Tn3 transposon. It is also homologous with the gin gene carried on bacteriophage mu. These relationships suggest that the phase variation system may have evolved by the association of a transposon with a resident gene and the subsequent specialization of these elements to regulate flagellar antigen expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, M -- Zieg, J -- Silverman, M -- Mandel, G -- Doolittle, R -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1370-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251543" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Bacterial Proteins/*genetics ; Base Sequence ; *DNA Transposable Elements ; DNA, Bacterial/genetics ; Flagellin/*genetics ; Genes ; Recombination, Genetic ; Salmonella/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Crisis in NIH funding (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesell, E S -- Mandel, H G -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063837" target="_blank"〉PubMed〈/a〉
    Keywords: *National Institutes of Health (U.S.) ; Research Support as Topic/*economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Oxygen consumption and cellular ion transport: evidence for adenosine triphosphate to O2 ratio near 6 in intact cell (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-06
    Description: Oxygen (O2) consumption and net K+ uptake were measured simultaneously upon reintroduction of K+ into a K+-depleted suspension of renal tubules. The K+/O2 stoichiometries of 11.8 +/- 0.2 and 8.4 +/- 0.6 were obtained for reduced nicotinamide adenine dinucleotide- and flavoprotein-linked substrates, respectively. These values complement classical K+ to adenosine triphosphate (ATP) and ATP/O2 stoichiometries, thereby demonstrating a remarkably efficient coupling between the processes of Na+- and K+-dependent adenosinetriphosphatase-mediated ion transport and oxidative phosphorylation within the intact cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, S I -- Balaban, R S -- Mandel, L J -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1148-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246581" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*metabolism ; Animals ; Biological Transport, Active ; Kidney Tubules/metabolism ; Mitochondria/metabolism ; NAD/metabolism ; Ouabain/pharmacology ; *Oxidative Phosphorylation ; *Oxygen Consumption/drug effects ; Potassium/*metabolism ; Rabbits ; Sodium-Potassium-Exchanging ATPase/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Simplified finite element mesh for dynamic analysis of a nuclear reactor building (1983)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 19 (1983), S. 1414-1420 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The design of nuclear facilities requires dynamic analysis to evaluate their performance during an earthquake. In modal analysis, a method recommended for dynamic analysis by the Nuclear Regulatory Commission, the natural frequencies and mode shapes of the structure are commonly calculated using a stiffness matrix computed using the finite element method.A primary goal of this study was to design a finite element mesh, capable of modelling a reactor structure, with a minimum number of nodes and elements. This is necessary since analysis using a mesh fine enough to include all of the structural elements is not feasible because of exorbitant computer time and storage requirements. It was found that for lateral motion, a representative reactor structure could be accurately modelled using a simplified mesh with only one isoparametric quadratic quadrilateral element per floor. In this mesh essentially infinite springs must be placed between the masses at each floor level to prevent internal movements of the lumped masses within the quadratic quadrilateral elements.It was also found that a structure with rigid heavy bottom floors and a light top floor can be subjected to large displacements in the top floor during earthquakes. It was concluded that the properties of that light top floor (especially shear area) controls the value of the fundamental frequency of the building.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620190911
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  • 8
    Electronic Resource
    Electronic Resource
    2-D multiplane finite element technique for solving a class of 3-D problems (1983)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 19 (1983), S. 113-124 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element technique, for efficient solution of a class of 3-D elasticity problems, is presented. In this method, standard 2-D finite elements are used along with a ‘connector’ element. An element, previously used to model material interfaces, is shown to provide the properties for use as a ‘connector’ element, if input variables are redefined. The accuracy of the technique is illustrated with a sample solution.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620190111
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  • 9
    Electronic Resource
    Electronic Resource
    Characteristics of plasma membrane isolated from a mouse T lymphoma line: comparison after nitrogen cavitation, shearing, detergent treatment, and microvesiculation (1982)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 20 (1982), S. 127-138 
    Details
    ISSN: 0730-2312
    Keywords: electron microscopy ; plasma membrane ; lymphoma cells ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Plasma membrane was isolated from the mouse T lymphoma cell line WEHI-22 using four different methods of cell disruption followed by centrifugal fractionation. Disruption by nitrogen cavitation or by shearing with a cell pump produced plasma membrane vesicles of similar buoyant density (1.10 g/ml) and morphological appearance. Few C-type virus particles were present. Cell disruption with 2% Tween-40 produced membrane vesicles of similar morphology but lower density (1.09 g/ml). All of the above preparations resulted in vesicles with aggregated intramembranous particles after freeze fracture. Microvesiculation with a sublytic concentration of a lysophosphatidylcholine analog (ET-12-H) (0.0032% w/v) produced small membrane vesicles which could be isolated without differential centrifugation. However, these had a slightly higher density than vesicles prepared by cavitation or shearing and were co ntaminated by virus particles. Unlike the other preparations, vesicles prepared with ET-I2-H had dispersed intramembranous particles. The enzyme γ-glutamyl transferase was enriched from 20- to 45-fold in the membrane preparations and proved a suitable plasma membrane marker for these cells whose 5′-nucleotidase content is very low.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240200205
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  • 10
    Electronic Resource
    Electronic Resource
    The physical chemistry of polyelectrolyte solutionsPaper presented at the meeting of the GDCh-Fachgruppe “Makromolekulare Chemie” on “Polymers and Water” in Bad Nauheim (W-Germany) on April 2/3 1984. (1984)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 123 (1984), S. 63-83 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Some physical properties of aqueous solutions containing linear, flexible, polyelectrolytes are reviewed in order to emphasize the role of charge interactions in these systems which strongly depend on the charge of the macromolecular chain and the concentration of low molar mass electrolyte in solution. Particular emphasis is put on polyelectrolyte solutions containing an excess of added salt, which from a theoretical point of view are easier to understand. Both the dilute and the semi-dilute case will be discussed. In the former the problem of the electrostatic potential around the macromolecular chain is briefly reviewed as well as the use of a wormlike chain model to derive average dimensions of polyelectrolytes in solutions. In the latter the scaling approach to concentration effects in polyelectrolyte solutions is briefly discussed. The pecularities of the semi-dilute regime in polyelectrolyte solutions is illustrated with the help of results obtained with dynamic light scattering and the time dependent decay of electric birefringence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1984.051230103
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