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  • Chemistry  (18)
  • Animals  (3)
  • FACILITIES, RESEARCH, AND SUPPORT  (3)
  • BIOTECHNOLOGY  (2)
  • 1980-1984  (11)
  • 1970-1974  (7)
  • 1955-1959  (5)
  • 1925-1929  (3)
  • 1
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    Polyene toxicity in renal medulla: injury mediated by transport activity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and thus increase the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited oxygen supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances thus appears to be mediated by increased oxygen demand for transport activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brezis, M -- Rosen, S -- Silva, P -- Spokes, K -- Epstein, F H -- AM18078/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322305" target="_blank"〉PubMed〈/a〉
    Keywords: Amphotericin B/adverse effects ; Animals ; Biological Transport, Active/drug effects ; Cell Membrane Permeability/drug effects ; Furosemide/pharmacology ; Glomerular Filtration Rate/drug effects ; Kidney Medulla/*drug effects/pathology ; Loop of Henle/drug effects ; Nystatin/adverse effects ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Polyenes/*adverse effects ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Hydrogen isotope ratios of mouse tissues are influenced by a variety of factors other than diet (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeNiro, M J -- Epstein, S -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1374-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Deuterium/*metabolism ; *Diet ; Hydrogen/*metabolism ; Mice ; Water/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: Groups of three to four mice were gavaged with aqueous solutions of 2 milligrams of morpholine, after which they were exposed to nitrogen dioxide in inhalation chambers at concentrations of 0.2 to 50 parts per million for up to 4 hours. At sequential intervals during the exposure, mice were frozen and pulverized in liquid nitrogen, and the mice powder was extracted with ice-cold 35 percent aqueous methanol and dichloromethane; organic-phase concentrates were analyzed for N-nitrosomorpholine with a thermal energy analyzer interfaced to a gas chromatograph. The N-nitrosomorpholine yields, ranging up to about 2.3 micrograms per mouse, were time-dependent relative to the duration of exposure to nitrogen dioxide and dose-dependent relative to the concentrations of nitrogen dioxide; control levels (in mice that were gavaged with morpholine or distilled water and then exposed to air instead of nitrogen dioxide) were less than 5 nanograms per mouse. These preliminary studies demonstrate the in vivo nitrosating potential of nitrogen oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iqbal, Z M -- Dahl, K -- Epstein, S S -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1475-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361099" target="_blank"〉PubMed〈/a〉
    Keywords: Amines/metabolism ; Animals ; Ascorbic Acid/pharmacology ; Biotransformation ; Dose-Response Relationship, Drug ; Mice ; Morpholines/*metabolism ; Nitrogen Dioxide/antagonists & inhibitors/*metabolism ; Nitrosamines/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Effects of an anti-G suit on the hemodynamic and renal responses to positive /+Gz/ acceleration (1974)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: The effects of the currently used U.S. Air Force (CSU-12/P) anti-G suit on renal function during positive radial acceleration (+Gz) were assessed in seven normal male subjects in balance on a 200 meq sodium diet. Following suit inflation in the seated position, +2.0 Gz for 30 min resulted in a decrease in the rate of sodium excretion from 125 plus or minus 19 to 60 plus or minus 14 microeq/min, which persisted during a 25-min recovery period. Fractional excretion of sodium also decreased significantly during +Gz. The magnitude of the antinatriuresis was indistinguishable from that observed during +Gz without suit inflation. In contrast to the antinatriuresis observed during centrifugation without suit, however, the antinatriuresis with suit was mediated primarily by an enhanced tubular reabsorption of sodium.
    Keywords: BIOTECHNOLOGY
    Type: Journal of Applied Physiology; 36; Mar. 197
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Large area pulse ionization chamber for measurement of extremely heavy cosmic rays (1970)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Parallel plate ionization chamber for identifying relativistic cosmic ray nuclei
    Keywords: FACILITIES, RESEARCH, AND SUPPORT
    Type: NASA-CR-116874
    Format: application/pdf
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  • 6
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    Effects of positive acceleration /+Gz/ on renal function and plasma renin in normal man (1974)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: The effects of positive radial centrifugation (+Gz) on plasma resin activity (PRA) and renal function were assessed in 15 normal male subjects under carefully controlled conditions of Na, K, and water intake. Twenty minutes of +2.0 Gz resulted in significant decreases in the mean rate of sodium excretion and creatine clearance and in a doubling of PRA in seven sodium-depleted subjects (10 meq Na intake). In eight sodium-replete subjects (200 mq Na intake), 30 min of +2.0 Gz was also associated with a decrease in the mean rate of sodium excretion. As a consequence of a concurrent decrease in creatine clearance, the fractional excretion of sodium during centrifugation did not differ from control, suggesting that the changes in Na excretion were mediated primarily by renal hemodynamic factors, although enhanced renal tubular sodium reabsorption may also have played a role.
    Keywords: BIOTECHNOLOGY
    Type: Journal of Applied Physiology; 36; Mar. 197
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    Low-frequency vibration qualification testing for Mariner Mars 1971 propellant tanks (1971)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: LF vibration qualification tests for Mariner Mars 1971 propellant tanks
    Keywords: FACILITIES, RESEARCH, AND SUPPORT
    Type: ANNUAL TECHNICAL MEETING AND EQUIPMENT EXPOSITION; Apr 26, 1971 - Apr 30, 1971; LOS ANGELES, CA
    Format: text
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  • 8
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    The M.I.T. Blowdown compressor facility (1974)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: A blowdown compressor test facility has been developed which allows time-resolved aerodynamic testing of full-scale transonic compressor rotors at low cost. The rotor is brought to speed in vacuum, a diaphragm is opened, and the test gas is allowed to flow for a time of the order of 0.1 sec, during which the rotor is driven by its own inertia. Both 'steady-state' performance evaluation and detailed time resolution of the flow on the blade-passing time scale have been demonstrated for a two-ft-diam transonic rotor with a tangential Mach number of 1.2 and a nominal pressure ratio of 1.6. The steady-state performance as determined in the experiments includes an efficiency of 0.92 and a pressure ratio of 1.55 at design speed. The time-resolved measurements include the combination tone structure in the upstream flow field, resolved both axially and radially, and the wake structure downstream of the rotor, also resolved both radially and axially.
    Keywords: FACILITIES, RESEARCH, AND SUPPORT
    Type: ASME PAPER 74-GT-47 , Gas Turbine Conference and Products Show; Mar 30, 1974 - Apr 04, 1974; Zurich; Switzerland
    Format: text
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    NASA TECHNICAL REPORTS
  • 9
    Electronic Resource
    Electronic Resource
    Kinetics of nucleic acid-large ligand interactions: Multiplet-closure approximations and matrix-iteration techniques (1981)
    New York : Wiley-Blackwell
    Biopolymers 20 (1981), S. 1651-1669 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Approximate methods are developed and evaluated for treating the rate of binding ligands that cover several contiguous sites to a homogeneous one-dimensional lattice, which represents a nucleic acid or other linear biopolymer. The model requires as input only the number of lattice sites necessary for binding, the total number (possibly infinite) of lattice sites, and elementary rate constants for the cooperative and noncooperative association and dissociation of the ligand on the lattice. The computational methods employed are an extension of the triplet closure approximation from the helix-coil (single-site ligand) problem to the large ligand binding problem. It is found that consideration of clusters of n + 2 lattice sites, where each ligand covers n sites, gives a surprisingly accurate description of the kinetics. The approximation is implemented by an extension of the matrix-iteration approach proposed by Craig and Crothers. The effects of the finite lattice length, as well as the capability to treat ligand motion along the lattice, are incorporated. When all symmetries are taken into consideration, the time required for the matrix iteration calculation rises only linearly with the ligand length n and is considerably less than that of the Monte Carlo method, which is used as a standard for comparison.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1981.360200808
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  • 10
    Electronic Resource
    Electronic Resource
    Kinetics of irreversible dissociation for proteins bound cooperatively to DNA (1984)
    New York : Wiley-Blackwell
    Biopolymers 23 (1984), S. 1249-1259 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We consider the irreversible dissociation kinetics of proteins that bind cooperatively and nonspecifically to DNA. Our model consists of an infinitely long one-dimensional nucleic acid lattice on which are bound protein ligands. A set of adjacent bound proteins forms a cluster of length n. A protein molecule may dissociate from any site within the bound cluster, not only from the ends, as was assumed in a previous model of this process due to Lohman [(1983) Biopolymers 22, 1697-1713]. By considering this additional pathway, we present a more general treatment of the dissociation kinetics of cooperatively bound ligands. We show that dissociation from the (n-2) internal positions of an n-cluster is an important pathway when the initial fractional saturation of the lattice is close to unity and the co operatively is low. When the fractional saturation is initially equal to 1 and the co operatively is low, our model does not give the zero-order dissociation kinetics predicted by the Lohman model.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360230709
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