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  • Engineering General  (136)
  • Humans  (127)
  • Female
  • 1985-1989  (282)
  • 1
    Electronic Resource
    Electronic Resource
    Analysis of laminated composite plates using a higher-order shear deformation theory (1985)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 2201-2219 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A higher-order shear deformation theory is used to analyse laminated anisotropic composite plates for deflections, stresses, natural frequencies and buckling loads. The theory accounts for parabolic distribution of the transverse shear stresses, and requires no shear correction coefficients. A displacement finite element model of the theory is developed, and applications of the element to bending, Vibration and stability of laminated plates are discussed. The present solutions are compared with those obtained using the classical plate theory and the three-dimensional elasticity theory.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620211207
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Curved beam elements to model noncircular coil shapes for tokamak reactor (1985)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 1853-1870 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The detailed stress analysis of the toroidal field superconducting coil is needed to ensure its structural integrity, which includes conductor breakage, insulation breakage, sliding between two turns, or support structure failure. Such detailed-analysis requires that each of the superconducting coil turns be modelled separately. In this paper, a curved beam finite element,13 having constant radius of curvature, is considered to model a turn of a noncircular toroidal field coil. Four different coil shapes subjected to electromagnetic body forces due to toroidal magnetic fields are analysed to assess the finite element models: circular, elliptic, Princeton-D8 and compound shape9. The comparison of analytical and finite element analysis results for resultant forces, tensions and displacements suggest that the proposed approach may be extended to the detailed stress analysis of the noncircular toroidal field superconducting coil.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620211010
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An inverse finite element method with an application to extrusion with solidification (1989)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 9 (1989), S. 541-555 
    Details
    ISSN: 0271-2091
    Keywords: Inverse finite elements ; Solidification ; Extrusion ; Metal casting ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The flow and solidification of planar jets are analysed by means of an efficient inverse isotherm finite element method. The method is based on a tessellation that is constructed by isotherms as characteristic co-ordinate lines transverse to the flow direction. Thus opposite sides of finite elements lie on isotherms. The method allows the simultaneous determination of the location of the isotherms with the primary unknowns, namely, the velocity, the pressure, the temperature and the location of the free surface. Thus the determination of the location of the solidification front (which is known to pose significant computational difficulties) is automatic. This facilitates the control of the location of the solidification front by controlling macroscopic variables such as the flow rate, the cooling rate and the capillary design. The location of the solidification may then be suitably chosen to influence the frozen-in orientation and structure in extrusion of high-performance materials such as composites and polymers, in continuous casting of metals and in growth of crystals.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650090505
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  • 4
    Electronic Resource
    Electronic Resource
    Finite-element analysis of fluid flow and heat transfer for staggered bundles of cylinders in cross flow (1987)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 7 (1987), S. 1325-1342 
    Details
    ISSN: 0271-2091
    Keywords: Convective Heat Transfer ; Finite Elements ; Navier-Stokes Equations ; Numerical Results ; Penalty Model ; Staggered Cylinders ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The two-dimensional Navier-Stokes equations and the energy equation governing steady laminar incompressible flow are solved by a penalty finite-element model for flow across finite depth, five-row deep, staggered bundles of cylinders. Pitch to diameter ratios of 1·5 and 2·0 are considered for cylinders in equilateral triangular and square arrangements. Reynolds numbers studied range from 100 to 400, and a Prandtl number of 0·7 is used. Velocity vector fields, streamline patterns, vorticity, pressure and temperature contours, local and average Nusselt numbers, pressure and shear stress distributions around the cylinder walls and drag coefficients are presented. The results obtained agree well with available experimental and numerical data.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650071204
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  • 5
    Electronic Resource
    Electronic Resource
    Direct cubic spline with application to quadrature (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 5 (1989), S. 237-246 
    Details
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a formulation of a cubic spline that fits the first derivatives of a function at mesh points and the function value and its second derivative at the beginning of the interval. Error bounds for the function and its first three derivatives are derived over the whole interval. This formulation can be applied, in particular, to quadratures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1630050404
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  • 6
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    Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-08
    Description: Overlapping complementary DNA clones were isolated from epithelial cell libraries with a genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is on chromosome 7. Transcripts, approximately 6500 nucleotides in size, were detectable in the tissues affected in patients with CF. The predicted protein consists of two similar motifs, each with (i) a domain having properties consistent with membrane association and (ii) a domain believed to be involved in ATP (adenosine triphosphate) binding. A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riordan, J R -- Rommens, J M -- Kerem, B -- Alon, N -- Rozmahel, R -- Grzelczak, Z -- Zielenski, J -- Lok, S -- Plavsic, N -- Chou, J L -- DK34944/DK/NIDDK NIH HHS/ -- DK39690/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 8;245(4922):1066-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2475911" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Biological Transport ; Cloning, Molecular/methods ; Cystic Fibrosis/*genetics/metabolism/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator ; DNA/*isolation & purification ; *Genes ; *Genes, Recessive ; Humans ; Ion Channels/pathology ; Membrane Proteins/*genetics/isolation & purification ; Molecular Sequence Data ; Peptides/*genetics/isolation & purification ; Sequence Homology, Nucleic Acid ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-03-17
    Description: Infections with the human malaria parasite Plasmodium falciparum are characterized by sequestration of erythrocytes infected with mature forms of the parasite. Sequestration of infected erythrocytes appears to be critical for survival of the parasite and to mediate immunopathological abnormalities in severe malaria. A leukocyte differentiation antigen (CD36) was previously suggested to have a role in sequestration of malaria-infected erythrocytes. CD36 was purified from platelets, where it is known as GPIV, and was shown to be a receptor for binding of infected erythrocytes. Infected erythrocytes adhered to CD36 immobilized on plastic; purified CD36 exhibited saturable, specific binding to infected erythrocytes; and purified CD36 or antibodies to CD36 inhibited and reversed binding of infected erythrocytes to cultured endothelial cells and melanoma cells in vitro. The portion of the CD36 molecule that reverses cytoadherence may be useful therapeutically for rapid reversal of sequestration in cerebral malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ockenhouse, C F -- Tandon, N N -- Magowan, C -- Jamieson, G A -- Chulay, J D -- New York, N.Y. -- Science. 1989 Mar 17;243(4897):1469-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2467377" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/immunology ; Antigens, CD36 ; Antigens, Differentiation/*metabolism ; Aotus trivirgatus ; Blood Platelets/*physiology ; Cell Adhesion ; Erythrocytes/*parasitology ; Humans ; In Vitro Techniques ; Plasmodium falciparum ; Platelet Membrane Glycoproteins/*physiology ; Receptors, Cell Surface/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Frame-shift deletions in patients with Duchenne and Becker muscular dystrophy (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-11-04
    Description: Duchenne muscular dystrophy (DMD) and its less severe form Becker muscular dystrophy (BMD) are allelic disorders. It has been suggested that in the mutations involving BMD, the translational reading frame of messenger RNA is maintained and a smaller, though partially functional, protein is produced. In order to test this, the exon-intron boundaries of the first ten exons of the DMD gene were determined, and 29 patients were analyzed. In a number of BMD patients (mild and severe BMD), the reading frame of messenger RNA was not maintained. On the basis of these findings, a model for reinitiation from an internal start codon is suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malhotra, S B -- Hart, K A -- Klamut, H J -- Thomas, N S -- Bodrug, S E -- Burghes, A H -- Bobrow, M -- Harper, P S -- Thompson, M W -- Ray, P N -- New York, N.Y. -- Science. 1988 Nov 4;242(4879):755-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Department, Hospital for Sick Children, Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3055295" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Blotting, Southern ; Chromosome Deletion ; DNA Probes ; Dystrophin ; Exons ; Genes ; Humans ; Muscle Proteins/*genetics ; Muscular Dystrophies/*genetics ; Mutation ; Phenotype ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-28
    Description: The search for new congeners of the leading anticancer drug doxorubicin has led to an analog that is approximately 1000 times more potent, noncardiotoxic at therapeutic dose levels, and non-cross-resistant with doxorubicin. The new anthracycline, 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin (MRA-CN), is produced by incorporation of the 3' amino group of doxorubicin in a new cyanomorpholinyl ring. The marked increase in potency was observed against human ovarian and breast carcinomas in vitro; it was not accompanied by an increase in cardiotoxicity in fetal mouse heart cultures. Doxorubicin and MRA-CN both produced typical cardiac ultrastructural and biochemical changes, but at equimolar concentrations. In addition, MRA-CN was not cross-resistant with doxorubicin in a variant of the human sarcoma cell line MES-SA selected for resistance to doxorubicin. Thus antitumor efficacy was dissociated from both cardiotoxicity and cross-resistance by this modification of anthracycline structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sikic, B I -- Ehsan, M N -- Harker, W G -- Friend, N F -- Brown, B W -- Newman, R A -- Hacker, M P -- Acton, E M -- CA 24543/CA/NCI NIH HHS/ -- CA 32250/CA/NCI NIH HHS/ -- CA 33303/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1544-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012308" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Breast Neoplasms/drug therapy ; Cell Line ; Chemical Phenomena ; Chemistry ; Dose-Response Relationship, Drug ; Doxorubicin/adverse effects/*analogs & derivatives/therapeutic use ; Female ; Heart/drug effects ; Humans ; Isoenzymes ; L-Lactate Dehydrogenase/analysis ; Mice ; Myocardium/enzymology ; Ovarian Neoplasms/drug therapy ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Bilirubin is an antioxidant of possible physiological importance (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-02-27
    Description: Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated chemically in either homogeneous solution or multilamellar liposomes. The antioxidant activity of bilirubin increases as the experimental concentration of oxygen is decreased from 20% (that of normal air) to 2% (physiologically relevant concentration). Furthermore, under 2% oxygen, in liposomes, bilirubin suppresses the oxidation more than alpha-tocopherol, which is regarded as the best antioxidant of lipid peroxidation. The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stocker, R -- Yamamoto, Y -- McDonagh, A F -- Glazer, A N -- Ames, B N -- AM 26307/AM/NIADDK NIH HHS/ -- CA 39910/CA/NCI NIH HHS/ -- ES 01896/ES/NIEHS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1987 Feb 27;235(4792):1043-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3029864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antioxidants ; Bilirubin/*physiology ; Biliverdine/metabolism ; Carotenoids/pharmacology ; Free Radicals ; Humans ; Hydrogen Peroxide ; Linoleic Acid ; Linoleic Acids/metabolism ; Liposomes/metabolism ; Oxidation-Reduction ; Oxygen/pharmacology ; Photochemistry ; Superoxides ; Vitamin E/pharmacology ; beta Carotene
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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