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  • GEOPHYSICS  (462)
  • ASTROPHYSICS  (417)
  • Animals  (292)
  • Male
  • Molecular Sequence Data
  • 1985-1989  (1,212)
  • 1
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    Expression and properties of two types of protein kinase C: alternative splicing from a single gene (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-05-29
    Description: Two complementary DNA's, encoding the complete sequences of 671 and 673 amino acids for subspecies of rat brain protein kinase C, were expressed in COS 7 cells. The complementary DNA sequence analysis predicted that the two enzymes are derived from different ways of splicing and differ from each other only in the short ranges of their carboxyl-terminal regions. Both enzymes showed typical characteristics of protein kinase C that responded to Ca2+, phospholipid, and diacylglycerol. The enzymes showed practically identical physical and kinetic properties and were indistinguishable from one of the several subspecies of protein kinase C that occurs in rat brain but not in untransfected COS 7 cells. Partial analysis of the genomic structure confirmed that these two subspecies of protein kinase C resulted indeed from alternative splicing of a single gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ono, Y -- Kikkawa, U -- Ogita, K -- Fujii, T -- Kurokawa, T -- Asaoka, Y -- Sekiguchi, K -- Ase, K -- Igarashi, K -- Nishizuka, Y -- New York, N.Y. -- Science. 1987 May 29;236(4805):1116-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3576226" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Brain/enzymology ; Chromatography, High Pressure Liquid ; DNA/genetics ; Nucleic Acid Hybridization ; Protein Kinase C/*genetics/metabolism ; RNA Splicing ; Rabbits ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Measurements of nitric oxide and total reactive nitrogen in the Antarctic stratosphere - Observations and chemical implications (1989)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Results are presented on measurements of NO and the sum of reactive nitrogen species, NO(y), which include NO, NO2, NO3, N2O5, HNO3, and ClONO2 (in addition to ClO, O3, H2O, and N2O measurements), obtained aboard the NASA ER-2 aircraft flying over the Antarctica between the latitudes of 53 and 72 deg S during the Airborne Antarctic Ozone Experiment. The boundary of the chemically perturbed region (CPR), as indicated by a sharp increase in the level of ClO, occurred near 66 deg S; outside or equatorward of the CPR, the NO(y) mixing ratios ranged between 6 and 12 ppbv, with values decreasing poleward and reaching total NO(y) levels of 4 ppbv or less within 5-deg poleward of the boundary. Data presented in this paper clearly associate the Antarctic ozone decrease with perturbed conditions of ClO, NO(y), and H2O, which are in turn associated with processes defined as nonstandard heterogeneous chemistry, denitrification, and dehydration, respectively.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 94; 16665-16
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  • 3
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    Emission, absorption and group delay of microwaves in the atmosphere in relation to water vapour content over the Indian subcontinent (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: The advent of satellite communication for global coverage has apparently indicated a renewed interest in the studies of radio wave propagation through the atmosphere, in the VHF, UHF and microwave bands. The extensive measurements of atmosphere constituents, dynamics and radio meterological parameters during the Middle Atmosphere Program (MAP) have opened up further the possibilities of studying tropospheric radio wave propagation parameters, relevant to Earth/space link design. The three basic parameters of significance to radio propagation are thermal emission, absorption and group delay of the atmosphere, all of which are controlled largely by the water vapor content in the atmosphere, particular at microwave bands. As good emitters are also good absorbers, the atmospheric emission as well as the absorption attains a maximum at the frequency of 22.235 GHz, which is the peak of the water vapor line. The group delay is practically independent of frequency in the VHF, UHF and microwave bands. However, all three parameters exhibit a similar seasonal dependence originating presumably from the seasonal dependence of the water vapor content. Some of the interesting results obtained from analyses of radiosonde data over the Indian subcontinent collected by the India Meteorological Department is presented.
    Keywords: GEOPHYSICS
    Type: International Council of Scientific Unions Handbook for MAP, Vol. 18; p 399-404
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  • 4
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    Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-04-04
    Description: Experiments were conducted to isolate and characterize the gene and gene product of a human hematopoietic colony-stimulating factor with pluripotent biological activities. This factor has the ability to induce differentiation of a murine myelomonocytic leukemia cell line WEHI-3B(D+) and cells from patients with newly diagnosed acute nonlymphocytic leukemia (ANLL). A complementary DNA copy of the gene encoding a pluripotent human granulocyte colony-stimulating factor (hG-CSF) was cloned and expressed in Escherichia coli. The recombinant form of hG-CSF is capable of supporting neutrophil proliferation in a CFU-GM assay. In addition, recombinant hG-CSF can support early erythroid colonies and mixed colony formation. Competitive binding studies done with 125I-labeled hG-CSF and cell samples from two patients with newly diagnosed human leukemias as well as WEHI-3B(D+) cells showed that one of the human leukemias (ANLL, classified as M4) and the WEHI-3B(D+) cells have receptors for hG-CSF. Furthermore, the murine WEHI-3B(D+) cells and human leukemic cells classified as M2, M3, and M4 were induced by recombinant hG-CSF to undergo terminal differentiation to macrophages and granulocytes. The secreted form of the protein produced by the bladder carcinoma cell line 5637 was found to be O-glycosylated and to have a molecular weight of 19,600.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Souza, L M -- Boone, T C -- Gabrilove, J -- Lai, P H -- Zsebo, K M -- Murdock, D C -- Chazin, V R -- Bruszewski, J -- Lu, H -- Chen, K K -- CA00966/CA/NCI NIH HHS/ -- CA20194/CA/NCI NIH HHS/ -- CA32516/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Apr 4;232(4746):61-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2420009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cell Line ; Colony-Forming Units Assay ; Colony-Stimulating Factors/genetics/*pharmacology ; DNA/metabolism ; Escherichia coli/genetics ; Genes ; Granulocyte Colony-Stimulating Factor ; Granulocytes/*physiology ; Humans ; Leukemia/*pathology ; Leukemia, Myeloid/pathology ; Mice ; Plasmids ; Recombinant Proteins/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-03-06
    Description: Atrial natriuretic factor (ANF) is a peptide hormone that is released from atria and regulates a number of physiological processes, including steroidogenesis in adrenal cortex and testes. The parallel stimulation of membrane guanylate cyclase and corticosterone production in isolated fasciculata cells of rat adrenal cortex has supported the hypothesis of a mediatory role for cyclic guanosine monophosphate (cyclic GMP) in signal transduction. A novel particulate guanylate cyclase tightly coupled with ANF receptor was purified approximately 273,000-fold by two-step affinity chromatography. The enzyme had a molecular size of 180 kilodaltons and was acidic in nature with a pI of 4.7. Its specific activity was 1800 nanomoles of cyclic GMP formed per minute per milligram of protein. The purified enzyme bound ANF with a specific binding activity of 4.01 nanomoles per milligram of protein, a value that is close to the theoretical binding activity of 5.55 nanomoles per milligram of protein for 1 mole of the ligand binding 1 mole of the receptor protein. These results indicate that the guanylate cyclase-coupled ANF receptor exists in a 180-kilodalton protein of rat adrenocortical carcinoma and represent a step toward the elucidation of the basic mechanism of cyclic GMP-mediated transmembrane signal transduction in response to a hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, A K -- Marala, R B -- Jaiswal, R K -- Sharma, R K -- NS23744/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 6;235(4793):1224-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2881352" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex ; Adrenal Gland Neoplasms/enzymology/metabolism/pathology ; Animals ; Carcinoma/enzymology/metabolism/pathology ; Cell Membrane/enzymology/metabolism ; Guanylate Cyclase/isolation & purification/*metabolism ; Membrane Proteins/*metabolism ; Rats ; Receptors, Atrial Natriuretic Factor ; Receptors, Cell Surface/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-29
    Description: The transfer of the human gene for hypoxanthine phosphoribosyltransferase (HPRT) into human bone marrow cells was accomplished by use of a retroviral vector. The cells were infected in vitro with a replication-incompetent murine retroviral vector that carried and expressed a mutant HPRT complementary DNA. The infected cells were superinfected with a helper virus and maintained in long-term culture. The production of progeny HPRT virus by the bone marrow cells was demonstrated with a colony formation assay on cultured HPRT-deficient, ouabain-resistant murine fibroblasts. Hematopoietic progenitor cells able to form colonies of granulocytes or macrophages (or both) in semisolid medium in the presence of colony stimulating factor were present in the nonadherent cell population. Colony forming units cloned in agar and subsequently cultured in liquid medium produced progeny HPRT virus, indicating infection of this class of hematopoietic progenitor cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gruber, H E -- Finley, K D -- Hershberg, R M -- Katzman, S S -- Laikind, P K -- Seegmiller, J E -- Friedmann, T -- Yee, J K -- Jolly, D J -- AM 13622/AM/NIADDK NIH HHS/ -- GM 28223/GM/NIGMS NIH HHS/ -- HD20034/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1057-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3864246" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Gene Expression Regulation ; *Genetic Engineering ; Genetic Vectors ; Hematopoietic Stem Cells/*physiology ; Humans ; Hypoxanthine Phosphoribosyltransferase/*genetics ; Mice ; Retroviridae/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Prostacyclin stimulation of the activation of blood coagulation factor X by platelets (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-24
    Description: When platelets were incubated with prostacyclin, prostaglandin E1, or prostaglandin D2 at concentrations insufficient to increase the level of adenosine 3',5'-monophosphate (cyclic AMP), coagulation factor X was activated by a platelet cysteine protease. Prostacyclin or prostaglandin E1 at higher concentrations increased the cyclic AMP level and inhibited the activation of factor X by platelets. Inhibition of platelet adenylate cyclase by 2',5'-dideoxyadenosine allowed the activation of the protease at higher concentrations of the autocoids. Prostaglandins A1, A2, B1, B2, E2, F2 alpha, 6-keto-prostaglandin F1 alpha, and thromboxane B2, which do not affect platelet cyclic AMP level, did not stimulate the protease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dutta-Roy, A K -- Ray, T K -- Sinha, A K -- New York, N.Y. -- Science. 1986 Jan 24;231(4736):385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3001935" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Alprostadil/pharmacology ; Animals ; Blood Platelets/*drug effects/metabolism/physiology ; Cattle ; Cyclic AMP/metabolism ; Deoxyadenosines/analogs & derivatives/pharmacology ; *Dideoxyadenosine/*analogs & derivatives ; Epoprostenol/*pharmacology ; Factor X/*physiology ; Humans ; Peptide Hydrolases/metabolism ; Prostaglandin D2 ; Prostaglandins/pharmacology ; Prostaglandins D/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Composition of comet Halley dust particles from Giotto observations (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Mass spectra of cometary dust particles measured by the PIA dust particle analyzer aboard the Giotto spacecraft show some unexpected and striking features. First, small particles below 10 to the -14th g are much more abundant than anticipated by models. Second, most of the particles are rich in light elements such as H, C, N, and O, suggesting the validity of models that describe the cometary dust as including organic material. Third, the light elements specifically seem to have a low ratio of mass to volume. Three examples of original mass spectra showing typical compositions are given; these have been measured, and are compared with a computer-simulated mass spectrum.
    Keywords: ASTROPHYSICS
    Type: Nature (ISSN 0028-0836); 321; 336
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  • 9
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    A disturbance of the ion tail of Comet Halley and the heliospheric structure as observed by Sakigake (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: In order to study the interaction between the solar wind measured by Sakigake and ion tail disturbances of comet Halley, more than 500 photographs of the comet taken on the ground during this apparition are surveyed. The focus of the present study is the December 31, 1985, event, when various types of disturbances occurred, including an outstanding disconnection event (DE)-like knot. Analysis of the Sakigake/IMF data reveals that comet Halley did not encounter the heliospheric neutral sheet on that day, demanding a new explanation for the DE-like event, different from the Niedner-Brandt model. During this event the comet encountered a high-speed solar wind stream from a coronal hole tongue of the sun. The event can be explained by a dynamic pressure model, according to which the DE-like plasmoid was caused by a sudden increase in the dynamic pressure of the solar wind. A result of the simulation work by Ogino is found to support this interpretation.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 13; 821-824
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  • 10
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    Structure and dynamics of the plasma tail of comet P/Halley. I - Knot event on December 31, 1985 (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: On the basis of about 500 photographs of comet Halley taken by many observers, Saito et al. (1986) classified the detected disturbances of the plasma tail as outstanding rays, streamer, helix, kink, arcade, and disconnection event (DE). In this paper, the interaction of the solar wind with the plasma tail of Comet P/Halley is examined by using results of observations by the Sakigake spacecraft of the December 31, 1985 event, which included various disturbances and one DE-like knot. On the basis of twenty photographs taken on December 31 by Japanese astronomers, the dynamic pressure model proposed by Saito et al. (1986) is examined, and the mechnism of the knot event that appeared in the plasma tail of the comet on December 31, is explained.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 187; 1-2,
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