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  • SPACE RADIATION  (677)
  • Cell & Developmental Biology  (636)
  • 1985-1989  (665)
  • 1970-1974  (457)
  • 1960-1964  (133)
  • 1950-1954  (38)
  • 1935-1939  (20)
Collection
Keywords
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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  • 2
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    Pioneer 10 observations of the solar wind interaction with Jupiter (1974)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Detailed analysis of the Pioneer 10 plasma analyzer experiment flight data during the Jupiter flyby in late November and early December 1973 has been performed. The observations show that the interaction of Jupiter's magnetic field with the solar wind is similar in many ways to that at earth, but the scale size is over 100 times larger. Jupiter is found to have a detached standing bow shock wave of high Alfven Mach number. Like the earth, Jupiter has a prominent magnetopause that deflects the magnetosheath plasma and excludes its direct entry into the Jovian magnetosphere. Unlike that of the earth, the sunward hemisphere of Jupiter's outer magnetosphere is found to be highly inflated with thermal plasma and a high-beta region that is highly responsive to changes in solar wind dynamic pressure.
    Keywords: SPACE RADIATION
    Type: Journal of Geophysical Research; 79; Sept. 1
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Pioneer 10 observations of the solar wind interation with Jupiter (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Pioneer 10 Plasma Analyzer experiment flight data during the Jupiter flyby are presented. The observations show that the interaction of Jupiter's magnetic field with the solar wind is similar in many ways to that at earth, but the scale size is over 100 times larger. Jupiter is found to have a detached standing bow shock wave of high Alfven Mach number. Jupiter has a prominent magnetopause which deflects the magnetosheath plasma and excludes its direct entry into the Jovian magnetosphere. The sunward hemisphere of Jupiter's outer magnetosphere is found to be highly inflated with thermal plasma and a high beta region which is highly responsive to changes in solar wind dynamic pressure. Observational arguments are presented which tend to discount a thin disklike magnetosphere but, rather, favor a Jovian magnetosphere, albeit probabily considerably flattened as compared to the earth's magnetosphere, yet still with reasonable thickness. Results concerning the shock jump conditions, the magnetosheath flow field and inferred internal magnetospheric plasma are presented.
    Keywords: SPACE RADIATION
    Type: NASA-TM-X-62357
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Composition of interplanetary particles at energies from 0.1 to 150 MeV/nucleon, part B (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: During the Apollo 16 mission, a solar flare produced an enormous amount of low-energy nuclei, many orders of magnitude greater than the level inferred from studies of tracks in the window of the Apollo 12 spacecraft during a time when the sun was quiet. The differential energy spectrum of nuclei with Z less than or equal to 6 falls by seven orders of magnitude over the interval from 0.1 to 20 MeV/nucleon, then remains almost flat up to approximately 100 MeV/nucleon. The two parts correspond to contributions from the sun and from galactic cosmic rays. Any maximum in the spectrum occurs below the lowest energy studied.
    Keywords: SPACE RADIATION
    Type: NASA. Lyndon B. Johnson Space Center Apollo 16 Prelim. Sci. Rept.; 8 p
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Arcsecond Positions for Milliarcsecond VLBI Nuclei of Extragalactic Radio Sources. Part 3: 74 Sources (1985)
    In:  CASI
    Details
    Publication Date: 2014-09-18
    Description: VLBI measurements at 2290 MHz and 8420 MHz on baselines of 10,000 km between Deep Space Network stations have been used to determine the positions of the milliarcsecond nuclei in 74 extragalactic radio sources. Estimated accuracies range from 0.1 sec. to 4, 3 sec. in both right ascension and declination with typical accuracies of approx. 0.3 sec. The observed sources are part of an all-sky VLBI catalog of milliarcsecond radio sources. Arcsecond positions have now been determined for 819 sources. These positions are presently being used to identify optical counterparts in the Southern Hemisphere.
    Keywords: SPACE RADIATION
    Type: The Telecommun. and Data Acquisition Rept.; p 1-7
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    High energy gamma ray balloon instrument (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The High Energy Gamma Ray Balloon Instrument was built in part to verify certain subsystems' performance for the Energetic Gamma Ray Experiment Telescope (EGRET) instrument, the high energy telescope to be carried on the Gamma Ray Observatory. This paper describes the instrument, the performance of some subsystems, and some relevant results.
    Keywords: SPACE RADIATION
    Type: OG-9.2-12 , 19th Intern. Cosmic Ray Conf - Vol. 3; p 338-341; NASA-CP-2376-VOL-3
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
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    EAS spectrum in the primary energy region above 10 to the 15th power eV by the Akeno and Yakutsk array data (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The extensive air showers spectrum on scintillation desity Rko in primary energy region E sub approx. 10 to the 15th power - 10 to the 20th power eV on the Yakutsk array data and recent results of the Akeno is given.
    Keywords: SPACE RADIATION
    Type: OG-5.1-16 , 19th Intern. Cosmic Ray Conf - Vol. 2; p 194-197; NASA-CP-2376-VOL-2
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
    Electronic Resource
    Electronic Resource
    Lymph heart musculature in birds (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 191 (1987), S. 77-87 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Development and innervation of the lymph heart musculature of chicken, emu, rhea, and duck was studied by electron microscopy at posthatch ages from 3 days to adulthood. Development of innervation was monitored by acetylcholinesterase staining. Horseradish peroxidase was used to determine the extent of the transverse tubule network. Chickens were unusual among these birds in that lymph heart myocytes had already undergone a definitive differentiation and degeneration by 3 days. In ducks and ratite birds, lymph heart myocytes more slowly but progressively differentiate a cytomorphology that does not conform in all characteristics to cardiac or skeletal muscle and even resembles in some aspects, smooth muscle. Myofibrils become the dominant cytoplasmic structure, transverse tubules form ‘internal couplings’ with agranular reticulum cisternae, and ‘external couplings’ are formed between myocytes at myomyal junctions. The myomyal junctions also contain AChE-positive reaction product and some subplasmalemmal vesicles that lack a dense core. The lymph heart myocardium of ducks of 2 weeks demonstrated mitotic figures. In adult ducks the myosatellite cell numbers diminish and a characteristic pattern of myocyte degeneration appears. In juvenile ducks and ratites some myocytes differentiate to conductile cells, much as the conductile myocytes and myofibers of the blood heart. The lymph heart innervation is described, and the role of nerve in differentiation and maintenance of myocyte morphology in the lymph heart is discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051910108
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  • 9
    Electronic Resource
    Electronic Resource
    Cytotoxicity of gelonin and its conjugates with antibodies is determined by the extent of their endocytosis (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 141 (1989), S. 222-234 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Conjugates of the single-chain ribosome-inactivating protein gelonin with ligands that bind to cell surface molecules vary greatly in their cytotoxicity. Conjugates that are not endocytosed after binding to cells exhibit low cytotoxicity similar to that of free gelonin, while conjugates that are endocytosed demonstrate enhanced cytotoxicity relative to free gelonin. However, the number of internalized gelonin molecules needed to intoxicate cells to the same degree has been found to be similar for all conjugates and for free gelonin. The intracellular concentration of gelonin has to be between 2,000-10,000 molecules/cell to achieve a surviving fraction of 0.37. Our studies revealed the presence of three distinct categories of cell surface molecules, those that are efficient in mediating endocytosis of im-munotoxins, those that are only moderately efficient, and those that seem not to cause internalization of bound immunotoxins.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041410129
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  • 10
    Electronic Resource
    Electronic Resource
    Bone marrow-derived stromal cell line expressing osteoblastic phenotype in vitro and osteogenic capacity in vivo (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 140 (1989), S. 1-7 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Marrow stroma has been shown to have osteogenic potential. Here we report the characterization of a unique stromal cell line derived from mouse bone marrow (MBA-15), which expresses osteoblastic phenotype in vitro and forms bone in vivo. More than 70% of cells in culture were histochemically positive for alkaline phosphatase. The enzyme levels were enhanced threefold when cultures were treated with dexamethasone. Gel electrophoresis of [3H]-proline-labeled cultures showed that MBA-15 cells produced only type I collagen. These cells were responsive to PTH, as indicated by a 50-fold increase in intracellular cAMP. Prostaglandin E2, but not calcitonin, stimulated cAMP up to 70-fold. When cultures were grown to confluence and fed daily with ascorbic acid and β-glycerophosphate, the cells formed a Von Kossa positive, thick extracellular matrix, shown to contain hydroxyapatite crystals. MBA-15 cells produced mineralized bone when implanted in diffusion chambers. These results indicate that the MBA-15 cell line possesses osteoblastic features in vitro and osteogenic capacity in vivo.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041400102
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