ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Host-Guest Chemistry, V. Improved Syntheses of Macrocyclic Azacyclophanes - Temperature Effects on Ring Size Ratios in the CyclisationThe simplified reaction of (bis)tosylamides and α,ω-dibromoalkanes using K2CO3 in heterogeneous DMF solution as a deposit base allows to obtain large quantities of macrocycles (1 - 4) in 45 - 62% yields. The hitherto unknown temperature effect on the ratio of smaller to larger cyclophanes (diaza- to tetraaza rings, DR to TR) can be used to increase the DR/TR ratio, e.g. from 2.2 to 〉 28.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19861190232
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