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  • 1
    Electronic Resource
    Electronic Resource
    Biocompatibility testing of polymers: In vitro studies with in vivo correlation (1978)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 12 (1978), S. 43-54 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vitro method has been developed for screening of candidate biomaterials in an early phase of their development. The test is based on L-929 mouse fibroblast cultures and their response to powdered polymer samples. It applies microscopic observation for the detection of morphological changes, uses dye exclusion testing for cell viability determination, and utilizes estimation of population doublings as an end point. The test is shown to be reliable and reproducible and is compared to in vivo implantation studies in rats, previously reported.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820120105
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and bioevaluation of alkyl 2-cyanoacryloyl glycolates as potential soft tissue adhesives (1986)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 205-212 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A series of alkyl 2-cyanoacryloyl glycolate tissue adhesives were synthesized and characterized by NMR. Physical properties and bond strengths are presented. Within the series, bond strength decreased with increasing molecular weight. Corresponding polymers were evaluated by in vitro and in vivo techniques for biocompatibility. In general, in vitro biocompatibility increased with molecular weight. Based on in vitro and in vivo results, the isobutyl and isoamyl derivatives gave polymers that were most biocompatible, however, the entire series was found to be less reactive than poly(methyl 2-cyanoacrylate) and only the isopropyl derivative polymers more reactive than poly(isobutyl 2-cyanoacrylate). Approximately one-third of the isobutyl polymer biodegraded in vivo after 6 weeks.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820200209
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinically observed corrosion of surface defects of wires (1977)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 11 (1977), S. 625-628 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820110414
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  • 4
    Electronic Resource
    Electronic Resource
    Biocompatibility testing of polymers: In vivo implantation studiesAll reprint requests should be addressed to Librarian, USAMBRDL. (1978)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 12 (1978), S. 219-232 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The method is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820120207
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and bioevaluation of a rapidly biodegradable tissue adhesive: 1,2-Isopropylidene glyceryl 2-cyanoacrylate (1986)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 213-217 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A rapidly biodegradable tissue adhesive, 1,2-isopropylidene glyceryl 2-cyanoacrylate, was synthesized and characterized by NMR. Bond strength was determined. Three types of corresponding polymers were prepared and evaluated for in vitro and in vivo toxicity. The polymers were generally found to be in the moderately toxic and toxic groups similar to the lower alkyl 2-cyanoacrylates.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820200210
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  • 6
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    Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-08
    Description: Specific sigma binding sites have been identified in the mammalian brain and lymphoid tissue. In this study, certain gonadal and adrenal steroids, particularly progesterone, were found to inhibit sigma receptor binding in homogenates of brain and spleen. The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Su, T P -- London, E D -- Jaffe, J H -- New York, N.Y. -- Science. 1988 Apr 8;240(4849):219-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2832949" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Endocrine Glands/*physiology ; Guinea Pigs ; Haloperidol/metabolism ; *Immunity ; Male ; *Nervous System Physiological Phenomena ; Phenazocine/analogs & derivatives/metabolism ; Receptors, Opioid/*metabolism ; Receptors, sigma ; Spleen/metabolism ; Steroids/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 7
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    Strong electrical currents leave the primitive streak of chick embryos (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The electrical fields above chick embryos were explored with a vibrating probe. These fields indicate that steady currents with exit densities of the order of 100 microamperes per square centimeter leave the whole streak and return elsewhere through the epiblast. The epicenter of these strong exit currents lies near Hensen's node. They are probably pumped into the intraembryonic space by the epiblast and then leak out of the streak because it is a zone of junctional disruption.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaffe, L F -- Stern, C D -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):569-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo/*physiology ; Electric Conductivity ; Electricity ; Female ; Germ Layers/physiology ; Vitelline Membrane/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus eggs (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-07-22
    Description: Fertilization initiates in the egg a dramatic increase in intracellular calcium that opens ion channels and causes exocytosis. To explore the possibility that these events might involve a receptor-mediated pathway, receptors for serotonin or acetylcholine (M1 muscarinic) were expressed in the Xenopus egg; serotonin or acetylcholine then could initiate a series of responses similar to those normally initiated by sperm. Thus, there may be an endogenous receptor in the egg membrane that is activated by sperm, and the serotonin or M1 muscarinic receptor may replace the sperm receptor in this pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kline, D -- Simoncini, L -- Mandel, G -- Maue, R A -- Kado, R T -- Jaffe, L A -- New York, N.Y. -- Science. 1988 Jul 22;241(4864):464-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut Health Center, Farmington 06032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3134693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; Cytoplasmic Granules/physiology ; Endocytosis ; Exocytosis ; Female ; *Fertilization ; GTP-Binding Proteins/physiology ; Genetic Engineering ; Inositol Phosphates/physiology ; Male ; Membrane Potentials ; Receptors, Muscarinic/*physiology ; Receptors, Serotonin/*physiology ; Sperm-Ovum Interactions ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    An interstellar precursor mission (1977)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: A mission out of the planetary system, with launch about the year 2000, could provide valuable scientific data as well as test some of the technology for a later mission to another star. Primary scientific objectives for the precursor mission concern characteristics of the heliopause, the interstellar medium, stellar distances (by parallax measurements), low energy cosmic rays, interplanetary gas distribution, and mass of the solar system. Secondary objectives include investigation of Pluto. Candidate science instruments are suggested. Individual spacecraft systems for the mission were considered, technology requirements and problem areas noted, and a number of recommendations made for technology study and advanced development. The most critical technology needs include attainment of 50-yr spacecraft lifetime and development of a long-life NEP system.
    Keywords: ASTRONAUTICS (GENERAL)
    Type: NASA-CR-156152 , JPL-PUB-77-70
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 10
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    Imaging on ballistic missions to comet Encke (1975)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Imaging for navigation and science has been studied for a 1980 Encke flyby at 0.4 to 0.8 AU from the sun with spinning and three-axis spacecraft. Trajectory errors, maneuvers, encounter geometry, imaging performance, and data transmission were considered. Onboard comet sightings are needed for navigation. Recommended for a three-axis spacecraft are two vidicon cameras and a nucleus sensor for closed-loop pointing control. The cameras are essentially the Mariner 9 and Mariner 10 instruments; the nucleus sensor is an updated version of a sensor flown on Mariners 6 and 7. For a spinning spacecraft, a framing camera using a charge-coupled device and a spin-scan photometer are proposed. The framing camera would be a new design; it would not be despun, but the spin axis should point along the comet-centered velocity vector. The photometer is essentially that flown on Pioneer 10 and 11.-
    Keywords: ASTRONAUTICS (GENERAL)
    Type: AIAA PAPER 75-87 , American Institute of Aeronautics and Astronautics, Aerospace Sciences Meeting; Jan 20, 1975 - Jan 22, 1975; Pasadena, CA
    Format: text
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    NASA TECHNICAL REPORTS
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