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  • 1
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    Exposure of rats to alcohol in utero alters drug sensitivity in adulthood (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: Pregnant rats were intubated with alcohol (ethanol, 3 grams per kilogram) twice daily throughout gestation. Control animals received solutions of isocaloric sucrose. At birth, offspring were placed with untreated surrogate dams. Beginning at 6 months of age, the offspring were tested for their thermogenic responsiveness to various drugs and to cold. Prenatal exposure to alcohol resulted in tolerance to alcohol and cross-tolerance to pentobarbital and diazepam but did not affect responsiveness to cold. This pattern of effects suggest that prenatal exposure to alcohol produces specific long-term effects on the neural mechanisms underlying drug tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abel, E L -- Bush, R -- Dintcheff, B A -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1531-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chlorpromazine/pharmacology ; Dextroamphetamine/pharmacology ; Diazepam/pharmacology ; Drug Hypersensitivity ; Drug Tolerance ; Ethanol/*pharmacology ; Female ; Fetus/*drug effects ; Morphine/pharmacology ; Pentobarbital/pharmacology ; Pregnancy ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Artificial sweetener use and bladder cancer: a case-control study (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-14
    Description: In a case-control study of 302 male and 65 female bladder cancer patients and an equal number of other patients matched to them in age, sex, hospital, and hospital-room status, no association was found between use of artificial sweeteners or diet beverages and bladder cancer. No dose-response was observed with respect to quantity or duration of use of the two combined. No evidence was found to suggest that artificial sweeteners or diet beverages promote the tumorigenic effect of tobacco smoking. Artificial sweetener and diet beverage use strongly reflected socioeconomic status among controls with various diagnoses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wynder, E L -- Stellman, S D -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1214-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355283" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; Male ; Sex Factors ; Smoking/*complications ; Sweetening Agents/*adverse effects ; Urinary Bladder Neoplasms/chemically induced/*etiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Algebraic grid generation about wing-fuselage bodies (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: An algebraic procedure for generating boundary-fitted grids about wing-fuselage configurations is presented. A wing-fuselage configuration consists of two aircraft components specified by cross sections and mathematically represented by Coons' patches. Several grid blocks are constructed to cover the entire region surrounding the configuration, and each grid block maps into a computational cube. Grid points are first determined on the six boundary surfaces of a block and then in the interior. Grid points on the surface of the configuration are derived from the intersection of planes with the Coons' patch definition. Approximate arc length distributions along the resulting grid curves concentrate and disperse grid points. The two-boundary technique and transfinite interpolation are used to determine grid points on the remaining boundary surfaces and block interiors.
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 24; 868-872
    Format: text
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  • 4
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    Evidence of imbedded vortices in a three-dimensional shear flow (1981)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Vortex phenomena encountered in an investigation of the streamwise development of the three-dimensional wake region behind the tip of a three-dimensional wedge model are reported. Pressure profiles were measured by pitot probes downstream of a tip with a nearly constant surface pressure level and a nearly continuous surface curvature in a blowdown air tunnel operating at Mach 6. Rather than the simple three-dimensional quasi-parallel shear flow expected, the measurements indicated the presence of a flow with large deficits in longitudinal pitot pressure, which are usually associated with the core region of quasi-steady longitudinal vortices. Vapor screen flow visualizations also support the presence of longitudinal vortices located primarily in the tip region and evidently forming in the vicinity of the wake neck. An increase in overall wake thickness by 100% is also observed. The origin of the vortices as quasi-steady Taylor-Gortler vortices generated in the concavely curved shear layer near the wake neck is considered. It is pointed out that the existence of longitudinal vortexes suggests that three-dimensional turbulence modeling may be much more difficult than previously supposed.
    Keywords: AERODYNAMICS
    Type: AIAA Journal; 19; Mar. 198
    Format: text
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  • 5
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    Unsteady transonics of a wing with tip store (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 23; 662-668
    Format: text
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  • 6
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    Wind-tunnel investigation of the OMAC canard configuration (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Wind-tunnel tests were conducted on a 0.175-scale model of the OMAC Laser 300 canard configuration in the NASA Langley 12-Foot Low-Speed Wind Tunnel to determine its low-speed high angel-of-attack aerodynamic characteristics. The Laser 300 is a general aviation turboprop pusher aircraft utilizing a canard configuration. The design incorporates a low forward wing and a high main wing with a leading-edge droop installed on the outboard panel and tip fins mounted on the wing tips. The model was tested over a range of -6 to 50-deg angle-of-attack and 20 to -20 deg sideslip. Static force and moment data were measured, and the longitudinal and lateral-directional characteristics were determined.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 86-2608
    Format: text
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  • 7
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    Unsteady transonics of a wing with tip store (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The presence of tip stores influences both the aerodynamic and the aeroelastic performance of wings. Such effects are more pronounced in the transonic regime. In this study, a theoretical method is developed, for the first time, to compute unsteady transonics of oscillating wings with tip stores. The method is based on the small-disturbance, aerodynamic equations of motion from the potential-flow theory. To validate the method, subsonic and transonic aerodynamic computations are made for a lower-aspect-ratio wing, and they are compared with the available experimental data. Comparisons are favorable. The strong effects of the tip store on the transonic aerodynamics of the wing are also illustrated. The method developed in this steady can be used for transonic, aeroelastic computations of wings with tip stores.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 86-0010
    Format: text
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  • 8
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    Transonic aeroelasticity of wings with tip stores (1986)
    In:  Other Sources
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    Publication Date: 2019-06-28
    Description: The presence of tip stores influences both aerodynamic and aeroelastic performances of wings. Such effects are more pronounced in the transonic regime. In this study, transonic aeroelasticity of wings with tip stores is studied for the first time by a theoretical method using the unsteady-small disturbance transonic aerodynamic equations coupled with modal structural equations of motion. The aerodynamic and structural equations of motion are simultaneously integrated by a time-accurate numerical scheme. To validate the tip store simulation, aeroelastic computations are made for a typical rectangular wing with a tip store and results are correlated with available wind tunnel data for the corresponding wing without a tip store at various flight conditions. Aeroelastic computations are also made for a typical fighter wing with a tip store. Present computations show that it is important to account for the aerodynamics of the tip store, particularly in the transonic regime where the tip store can make the wing aeroelastically unstable.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 86-1007
    Format: text
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  • 9
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    Effects of cone surface waviness and freestream noise on transition in supersonic flow (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: A comparison of transition on wavy-wall and smooth-wall cones in a Mach 3.5 wind tunnel is made under conditions of either low freestream noise (quiet flow) or high freestream noise (noisy flow). The noisy flow compares to that found in conventional wind tunnels while the quiet flow gives transitional Reynolds numbers on smooth sharp cones comparable to those found in flight. The waves were found to have a much smaller effect on transition than similar sized trip wires. A satisfatory correlating parameter for the effect of waves on transition was simply the wave height-to-length ratio. A given value of this ratio was found to cause the same percentage change in transition location in quiet and noisy flows.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 86-1086
    Format: text
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  • 10
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    Algebraic grid generation for wing-fuselage bodies (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: An algebraic procedure for the generation of boundary-fitted grids about wing-fuselage configurations is presented. A wing-fuselage configuration is specified by cross sections and mathematically represented by Coons' patches. A configuration is divided into sections so that several grid blocks that either adjoin each other or partially overlap each other can be generated, and each grid has six surfaces that map into a computational cube. Grids are first determined on the six boundary surfaces and then in the interior. Grid curves that are on the surface of the configuration are derived using plane-patch intersections, and single-valued functions relating approximate arc lengths along the curves to computational coordinates define the distribution of grid points. The two-boundary technique and transfinite interpolation are used to determine the boundary surface grids that are not on the configuration, and transfinite interpolation with linear blending functions is used to determine the interior grids.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 84-0002
    Format: text
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