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  • Nudibranchia  (2)
  • controlled gastric emptying  (2)
  • Springer  (4)
  • 1985-1989  (2)
  • 1980-1984  (2)
  • 1965-1969
Collection
Keywords
Publisher
  • Springer  (4)
Years
  • 1985-1989  (2)
  • 1980-1984  (2)
  • 1965-1969
Year
  • 1
    Electronic Resource
    Electronic Resource
    Light and electron microscopic cytochemistry of the epidermal mucoid cells ofAeolidia papillosa andCoryphella rufibranchialis (Mollusca, Nudibranchia) (1983)
    Springer
    Protoplasma 114 (1983), S. 14-22 
    Details
    ISSN: 1615-6102
    Keywords: Cytochemistry ; Epidermis ; Golgi apparatus ; Mucoid cells ; Nudibranchia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The epidermal mucoid cells in the cerata ofAeolidia papillosa andCoryphella rufibranchialis were cytochemically tested to determine the composition of their secretory products. The PAS, alcian blue, PA-TSC-SP and high iron diamine stains were used to determine the presence of acidic, sulphated, and periodate-reactive groups on the mucopolysaccharides. The secretory granules in mucoid cells ofA. papillosa consisted of periodate-reactive mucopolysaccharides with acid groups other than sulphates. Each granule also contained fibrils which were not oxidized by periodic acid. The mucoid secretory granules inC. rufibranchialis contained weakly acidic sulphated mucopolysaccharides, but no periodate-reactive polysaccharide groups. In both aeolid nudibranchs the Golgi apparatus at the base of the mucoid cells contained products which stained the same as those in the secretory granules, confirming that the Golgi apparatus is involved in the synthesis of mucoid secretory products. In addition the mucoid cell Golgi complex ofC. rufibranchialis also gave rise to ellipsoid vacuoles which contained sulphated mucopolysaccharides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279864
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  • 2
    Electronic Resource
    Electronic Resource
    The Golgi apparatus in epidermal mucoid and ellipsoid-vacuolate cells ofAeolidia papillosa andCoryphella rufibranchialis (Nudibranchia) (1980)
    Springer
    Protoplasma 102 (1980), S. 217-233 
    Details
    ISSN: 1615-6102
    Keywords: Epidermis ; Golgi apparatus ; Nudibranchia ; Secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The epidermal cell layer of the apical end of the ceras was investigated in two species of aeolid nudibranchs. Based on cellular inclusions, mostly two cell types were found: mucoid and ellipsoid-vacuolate cells. Mucoid cells ofCoryphella rufibranchialis have large heterogeneous and fibrillar secretory granules whereas inAeolidia papillosa, the granules are homogeneous, but vary in electron density from one cell to another. Ellipsoid-vacuolate cells contained large quantities of small vacuoles with an included ellipsoidal structure. Both species contained very numerous ellipsoid-vacuolate cells. Secretory granules and ellipsoid-vacuoles appear to arise from the Golgi apparatus and these contents stain with PAS, suggesting a polysaccharide composition. Mucoid cells contained both secretory granules and ellipsoid-vacuoles which may arise from the same Golgi apparatus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279589
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  • 3
    Electronic Resource
    Electronic Resource
    Controlled Gastric Emptying. II. In Vitro Erosion and Gastric Residence Times of an Erodible Device in Beagle Dogs (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 506-509 
    Details
    ISSN: 1573-904X
    Keywords: controlled gastric emptying ; erodible device ; physical parameters ; dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An erodible gastric retention device fabricated from various polymeric blends was examined in vitro for its dissolution properties and in vivo in fasting dogs for assessment of its gastric retention potential. Dissolution studies were conducted with extruded rods of polymer blends to assess their potential as candidates for the erodible component of a gastrically retained device. Based on results from dissolution studies, rods of poly(ortho ester)/polyethylene blends (POE/PE) (45% erosion at pH 1.5 and 24 hr) were used to fabricate arms for tetrahedron-shaped devices. Corners for the tetrahedral device were fabricated from Silastic 382 loaded with 15% barium sulfate for X-ray visualization. Beagle dogs were dosed with tetrahedron-shaped test devices administered in gelatin capsules and gastric retention monitored by X ray over a 24-hr period. A comparison of in vitro erosion rates and in vivo performance of various polymer blends indicated a definite trend for increased gastric retention of devices made from the more slowly eroding blends. The results indicate that the blending of erodible and nonerodible polymers is a valid approach for obtaining materials that will provide the necessary structural properties to achieve gastric retention yet lose integrity within a desired time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015976709043
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  • 4
    Electronic Resource
    Electronic Resource
    Controlled Gastric Emptying. 1. Effects of Physical Properties on Gastric Residence Times of Nondisintegrating Geometric Shapes in Beagle Dogs (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 533-536 
    Details
    ISSN: 1573-904X
    Keywords: controlled gastric emptying ; nondisintegrating geometric shapes ; physical parameters ; dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The importance of three physical parameters (size, shape, and flexibility) on gastric retention in fasting dogs was examined to assess the feasibility of designing a dosage form to achieve a consistent and predictable residence in the stomach. Test shapes were molded from Silastic elastomer or made from extruded polyethylene or polyethylene blends and included 15% barium sulfate for X-ray visualization. Beagle dogs were dosed with test shapes administered in gelatin capsules. Gastric retention was monitored by X ray over a 24-hr period. Six shapes (ring, tetrahedron, cloverleaf, disk, string, and pellet) were screened in vivo for their gastric retention potential. The tetrahedrons (each leg 2 cm in length) exhibited 91–100% retention at 24 hr. The rings (3.6-cm diameter) provided 100% retention at 24 hr. Rings and tetrahedrons of varying flexural moduli were prepared by blending low-density polyethylene and ethylene: vinyl acetate copolymer. A positive correlation existed between flexural modulus and gastric retention. The results indicate that it is feasible to design a platform for a dosage form that can be administered to beagle dogs in capsule form and be retained for 24 hr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015981627525
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