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  • LUNAR AND PLANETARY EXPLORATION  (15)
  • Humans  (6)
  • OCEANOGRAPHY  (3)
  • 1985-1989  (10)
  • 1980-1984  (8)
  • 1975-1979  (6)
  • 1
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    Molecular defects in insulin action (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahn, C R -- Goldstein, B J -- New York, N.Y. -- Science. 1989 Jul 7;245(4913):13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2662406" target="_blank"〉PubMed〈/a〉
    Keywords: Diabetes Mellitus/*physiopathology ; Humans ; Insulin/*physiology ; Insulin Resistance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Contact-mediated bone resorption by human monocytes in vitro (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: Human circulating monocytes in tissue culture are capable of resorbing devitalized adult and fetal bone. An important component of this process is the adhesion of the cells to the mineralized substrate and the localized removal of matrix from beneath the attached cells. The process appears to involve both release of lysosomal enzymes onto the substrate and intracellular accumulation (transport) of resorbed matrix.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahn, A J -- Stewart, C C -- Teitelbaum, S L -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):988-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622581" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Matrix/cytology/metabolism/physiology ; *Bone Resorption ; Bone and Bones/embryology/metabolism ; Calcium Radioisotopes ; Cell Adhesion ; Culture Techniques ; Humans ; Monocytes/cytology/metabolism/*physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-08
    Description: Cultured human lymphocytes and rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoreses. In both cell types the 95,000-dalton (beta) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasuga, M -- Karlsson, F A -- Kahn, C R -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7031900" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Growth Hormone/pharmacology ; Humans ; Insulin/*pharmacology ; Liver Neoplasms, Experimental/metabolism ; Lymphocytes ; Macromolecular Substances ; Molecular Weight ; Phosphorylation ; Rats ; Receptor, Insulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Monocyte chemotaxis: stimulation by specific exosite region in thrombin (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-13
    Description: Human alpha-thrombin is a potent chemoattractant for human monocytes, with optimum activity occurring at about 10 nanomoles per liter. A variety of thrombins that were chemically modified to alter procoagulant or esterolytic functions showed a similar optimum activity, but complexes of prothrombin or alpha-thrombin with either antithrombin III or hirudin did not. These findings indicate that the regions in thrombin responsible for monocyte chemotaxis are proximate to those involved in certain protein recognition interactions of alpha-thrombin (for example, hirudin binding) but are distinct from the catalytic site and from certain exosites required for clotting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bar-Shavit, R -- Kahn, A -- Wilner, G D -- Fenton, J W 2nd -- DE-04629/DE/NIDCR NIH HHS/ -- HL-13160/HL/NHLBI NIH HHS/ -- HL-14147/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):728-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836310" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Chemotaxis, Leukocyte/*drug effects ; Hirudins/pharmacology ; Humans ; Monocytes/*drug effects ; Prothrombin/pharmacology ; Thrombin/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Human aging: usual and successful (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-07-10
    Description: Research in aging has emphasized average age-related losses and neglected the substantial heterogeneity of older persons. The effects of the aging process itself have been exaggerated, and the modifying effects of diet, exercise, personal habits, and psychosocial factors underestimated. Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the effects of aging alone, and successful aging, in which extrinsic factors play a neutral or positive role. Research on the risks associated with usual aging and strategies to modify them should help elucidate how a transition from usual to successful aging can be facilitated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowe, J W -- Kahn, R L -- New York, N.Y. -- Science. 1987 Jul 10;237(4811):143-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3299702" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; *Aging/metabolism/physiology/psychology ; Carbohydrate Metabolism ; Cognition ; Cross-Sectional Studies ; Grief ; Health Promotion ; Health Services for the Aged ; Humans ; Longitudinal Studies ; Osteoporosis/physiopathology ; Patient Acceptance of Health Care ; Reference Values ; Social Support ; Volition
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The Evolution of CO2 on Mars (1985)
    In:  CASI
    Details
    Publication Date: 2014-10-08
    Description: The consequences of the hypothesis that the evolution of CO2 is directly linked to the occurrence of at least transitory pockets of moisture were exposed. The current conditions preclude the existence of open bodies of liquid water and the formation of moisture in disequilibrium is not excluded by any known constraints. The water evaporation rate is inversely proportional to PCO2, and the existence of a limiting value (P*) for which liquid water can form in the Mars environment is postulated. The evolution of PCO2 is controlled largely by relatively rapid aqueous chemistry forming carbon-containing sedimentary rocks, perhaps during early history in open water, but more recently in transitory pockets of moisture in the soil. Once the total atmospheric pressure is reduced to near P*, the occurrence of transitory moisture is inhibited, and atmospheric CO2 is no longer depleted by an efficient mechanism. The role of the carbonate reservoir in the current overall carbon budget on Mars, according to this scheme, is illustrated.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA, Washington Repts. of Planetary Geol. and Geophys. Program; p 232-234
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  • 8
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    Ocean gravity and geoid determination (1979)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Gravity anomalies have been recovered in the North Atlantic and the Indian Ocean regions. Comparisons of 63 2 deg x 2 deg mean free air gravity anomalies recovered in the North Atlantic area and 24 5 deg x 5 deg mean free air gravity anomalies in the Indian Ocean area with surface gravimetric measurements have shown agreement to + or - 8 mGal for both solutions. Geoids derived from the altimeter solutions are consistent with altimetric sea surface height data to within the precision of the data, about + or - 2 m.
    Keywords: OCEANOGRAPHY
    Type: Journal of Geophysical Research; 84; July 30
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  • 9
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    Cratering and obliteration history of the south polar region of Mars (1987)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Results are presented from a comprehensive analysis of crater size frequency distributions compiled from Viking Orbiter images of Martian south polar terrains. Depositional histories for the various terrain units are modelled based on deviations of cumulative crater size frequency plots from an assumed production function. Stratigraphic and morphologic data obtained from visual examination of Viking images are also used, primarily to corroborate inferences concerning ages and obliteration histories derived from the crater data.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA, Washington, Reports of Planetary Geology and Geophysics Program, 1986; p 418-419
    Format: application/pdf
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  • 10
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    Mean sea level determination from satellite altimetry (1979)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: The primary experiment on the Geodynamics Experimental Ocean Satellite-3 (GEOS-3) is the radar altimeter. This experiment's major objective is to demonstrate the utility of measuring the geometry of the ocean surface; i.e., the geoid. Results obtained from this experiment so far indicate that the planned objectives of measuring the topography of the ocean surface with an absolute accuracy of + or - 5 m can be met and perhaps exceeded. The GEOS-3 satellite altimeter measurements have an instrument precision in the range of + or - 25 cm to + or - 50 cm when the altimeter is operating in the 'short pulse' mode. After one year's operations of the altimeter, data from over 5000 altimeter passes have been collected. With the mathematical models developed and the altimeter data presently available, mapping of local areas of ocean topography has been realized to the planned accuracy levels and better. This paper presents the basic data processing methods employed and some interesting results achieved with the early data. Plots of mean sea surface heights as inferred by the altimeter measurements are compared with a detailed 1 by 1 deg gravimetric geoid.
    Keywords: OCEANOGRAPHY
    Type: Marine Geodesy; 2; 2, 19; 1979
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