ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract We have investigated the role of interferon regulatory factor-1 (IRF-1), an interferon-γ (IFN-γ) inducible transcriptional activator, on major histocompatibility complex (MHC) class I gene transcription. IRF-1 alone is sufficient to trans-activate both transfected and endogenous class I genes and the effect of IRF-1 appears to be direct and sequence-specific. These data suggest that IRF-1 is involved in the IFN-γ mediated induction of MHC class I expression.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00179793
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