Publication Date:
1994-03-25
Description:
To complete their maturation, most immature thymocytes depend on the simultaneous engagement of their antigen receptor [alpha beta T cell receptor (TCR)] and their CD4 or CD8 coreceptors with major histocompatibility complex class II or I ligands, respectively. However, a normal subset of mature alpha beta TCR+ thymocytes did not follow these rules. These thymocytes expressed NK1.1 and a restricted set of alpha beta TCRs that are intrinsically class I-reactive because their positive selection was class I-dependent but CD8-independent. These cells were CD4+ and CD4-8- but never CD8+, because the presence of CD8 caused negative selection. Thus, neither CD4 nor CD8 contributes signals that direct their maturation into the CD4+ and CD4-8- lineages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bendelac, A -- Killeen, N -- Littman, D R -- Schwartz, R H -- New York, N.Y. -- Science. 1994 Mar 25;263(5154):1774-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7907820" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens/analysis
;
Antigens, CD4/analysis
;
Antigens, CD8/analysis
;
Antigens, Ly
;
Antigens, Surface
;
CD4-Positive T-Lymphocytes/cytology/*immunology
;
Female
;
Histocompatibility Antigens Class I/*physiology
;
Lectins, C-Type
;
Ligands
;
Lymphocyte Activation
;
Male
;
Mice
;
Mice, Inbred C57BL
;
NK Cell Lectin-Like Receptor Subfamily B
;
Phenotype
;
Proteins/analysis
;
Receptors, Antigen, T-Cell, alpha-beta/analysis/*physiology
;
T-Lymphocyte Subsets/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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