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  • SPACE RADIATION  (35)
  • METEOROLOGY AND CLIMATOLOGY  (2)
  • Mice  (2)
  • Astronomy
  • 1990-1994  (40)
  • 1
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    Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-23
    Description: The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) activity, infarct volumes decreased significantly 24 and 72 hours after middle cerebral artery occlusion, and the neurological deficits were less than those in normal mice. This result could not be accounted for by differences in blood flow or vascular anatomy. However, infarct size in the mutant became larger after endothelial NOS inhibition by nitro-L-arginine administration. Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Z -- Huang, P L -- Panahian, N -- Dalkara, T -- Fishman, M C -- Moskowitz, M A -- NS10828/NS/NINDS NIH HHS/ -- NS2636/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7522345" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/deficiency/*metabolism ; Animals ; Arginine/analogs & derivatives/pharmacology ; Brain/enzymology/*metabolism ; Brain Ischemia/complications/*metabolism ; Cerebral Infarction/*etiology ; Cerebrovascular Circulation ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Neurons/*enzymology ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-22
    Description: Long-term potentiation (LTP) is a persistent increase in synaptic strength implicated in certain forms of learning and memory. In the CA1 region of the hippocampus, LTP is thought to involve the release of one or more retrograde messengers from the postsynaptic cell that act on the presynaptic terminal to enhance transmitter release. One candidate retrograde messenger is the membrane-permeant gas nitric oxide (NO), which in the brain is released after activation of the neuronal-specific NO synthase isoform (nNOS). To assess the importance of NO in hippocampal synaptic plasticity, LTP was examined in mice where the gene encoding nNOS was disrupted by gene targeting. In nNOS- mice, LTP induced by weak intensity tetanic stimulation was normal except for a slight reduction in comparison to that in wild-type mice and was blocked by NOS inhibitors, just as it was in wild-type mice. Immunocytochemical studies indicate that in the nNOS- mice as in wild-type mice, the endothelial form of NOS (eNOS) is expressed in CA1 neurons. These findings suggest that eNOS, rather than nNOS, generates NO within the postsynaptic cell during LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Dell, T J -- Huang, P L -- Dawson, T M -- Dinerman, J L -- Snyder, S H -- Kandel, E R -- Fishman, M C -- DA-00074/DA/NIDA NIH HHS/ -- DA-00266/DA/NIDA NIH HHS/ -- MH-45923/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jul 22;265(5171):542-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7518615" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Oxidoreductases/antagonists & inhibitors/genetics/*metabolism ; Animals ; Arginine/*analogs & derivatives/pharmacology ; Electric Stimulation ; Endothelium/enzymology ; Hippocampus/drug effects/enzymology/*physiology ; In Vitro Techniques ; *Long-Term Potentiation/drug effects ; Mice ; Mutation ; Nitric Oxide/*metabolism ; Nitric Oxide Synthase ; Nitroarginine ; Pyramidal Cells/drug effects/enzymology/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Fast Fourier transformation results from gamma-ray burst profiles (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Several gamma-ray bursts in the BATSE data have sufficiently long durations and complex temporal structures with pulses that appear to be spaced quasi-periodically. In order to test and quantify these periods we have applied fast Fourier transformations (FFT) to all these events. We have also performed cross spectral analyses of the FFT of the two extreme (high-low) energy bands in each case to determine the lead/lag of the pulses in different energies.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 299-303.
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  • 4
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    A quantitative measure of the structure of gamma-ray burst time profiles (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A cursory examination of cosmic gamma-ray burst time profiles indicates an inhomogeneous distribution of structure. In the first approximation, there seem to be two types of profiles; smooth ones with little structure and highly variable ones with lots of structure. To put this observation to the test, we have examined the statistical nature of the profile derivative to choose which parameter might best be called the burst 'spikiness'. We have found that a good estimator is given by a count of the number of 'spikes' (defined by a specific numerical recipe) and not by the rms deviations from either a pre-burst background or any type of moving average background. The application of this parameter to 30 burst time histories shows it to be consistent over a wide range of profile types. The analysis also reveals a preferred average time between spikes of approximately 1.5 seconds.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 310-314.
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  • 5
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    Search for deterministic pulse trends in gamma ray burst temporal profiles (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Most cosmic gamma-ray burst temporal profiles appear to be comprised of several individual pulses, many of which overlap. It is advantageous to deconvolve the temporal structures into their constituent pulses, and thereby investigate the shape, intensity and temporal distributions of the pulses as a function of energy. Such fundamental pulse descriptors would provide constraints for theoretical modeling of the burst emission process, such as indications of source size, optical depth and geometry, as a function of time. We have developed a deconvolution algorithm which treats sequences of pulse shapes that change deterministically. The algorithm, a generalization of autoregressive techniques, has been applied to a few bright bursts observed by BATSE. Results indicate that, even within short intervals, constituent pulses are not self-similarly shaped, nor do pulse shapes evolve in a simple manner throughout a burst. Hence, the direction of our future work on pulse deconvolution will focus on analysis methods which allow pulse shape to vary.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 294-298.
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  • 6
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    Hardness/intensity correlations among BATSE bursts (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Conclusions about the nature of gamma-ray bursts derived from the size-frequency distribution may be altered if a significant correlation exists between burst intensity and spectral shape. Moreover, if gamma-ray bursts have a cosmological origin, such a correlation may be expected to result from the expansion of the universe. We have performed a rudimentary search of the BATSE bursts for hardness/intensity correlations. The range of spectral shapes was determined for each burst by computing the ratio of the intensity in the range 100-300 keV to that in 55-300 keV. We find weak evidence for the existence of a correlation, the strongest effect being present when comparing the maximum hardness ratio for each burst with its maximum rate.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 190-194.
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  • 7
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    BATSE spectroscopy results (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present preliminary analyses of gamma-ray burst spectra from the BATSE Spectroscopy Detectors. Our conclusions are: (1) No spectral lines have yet been detected in BATSE data from any cosmic gamma-ray burst. This is not surprising as the data for few bright bursts is available, and previous experiments saw lines in only a small fraction of the bursts. (2) Burst spectra show emission up to 20 MeV, with four of eight examined bursts having significant spectral breaks from 1 to 2 MeV. These breaks are consistent with opacity effects due to the interaction of photons with a high magnetic field. (3) Various distance independent parameters from burst spectra and time histories have no correlation with parameters related to distance. In other words, bright bursts look the same as faint bursts. This places a strong constraint on two population models of bursts. (4) The detection time of individual photons is not correlated from detector to detector, as predicted by Mitrofanov's pulsed emission model.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 180-189.
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  • 8
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    BATSE observations of gamma-ray bursts (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Gamma-ray bursts are being detected with unprecedented sensitivity by the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory since its launch in April, 1991. The experiment is detecting about one gamma-ray burst per day. A brief description is presented of the on-orbit performance of BATSE, the methods of identification of bursts, and examples of the diverse time profiles of the gamma-ray bursts observed. The most significant finding thus far is the apparent isotropy of the bursts together with the observed inhomogeneity of the sources.
    Keywords: SPACE RADIATION
    Type: In: Gamma-ray bursts; Proceedings of the Workshop, Univ. of Alabama, Huntsville, Oct. 16-18, 1991 (A93-40051 16-93); p. 13-21.
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  • 9
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    Gamma-ray monitoring of AGN and galactic black hole candidates by the Gamma-Ray Observatory (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Burst and Transient Spectroscopy Experiment (BATSE) on the Compton Gamma-Ray Observatory has a powerful capability to provide nearly uninterrupted monitoring in the 25 keV-10 MeV range of both AGN and Galactic black hole candidates such as Cygnus X-1, using the occultation of cosmic sources by the Earth. Progress in background modeling indicates that the data accept region, or fit window tau, around the occultation step can be substantially increased over that conservatively assumed in earlier estimates of BATSE's Earth occultation sensitivity. We show samples of large-tau fits to background and source edges. As a result we expect to be able to perform long-term monitoring of Cygnus X-1 and many of the brighter AGN for the duration of the CGRO mission.
    Keywords: SPACE RADIATION
    Type: In: Testing the AGN paradigm; Proceedings of the 2nd Annual Topical Astrophysics Conference, Univ. of Maryland, College Park, Oct. 14-16, 1991 (A93-29801 11-90); p. 356-361.
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  • 10
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    Effects of location uncertainties on the observed distribution of gamma-ray bursts detected by BATSE (1993)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Burst and Transient Source Experiment (BATSE) on NASA's Compton Gamma-Ray Observatory has shown that the sources of gamma-ray bursts have an angular distribution consistent with isotropy, yet the bursts are spatially inhomogeneous. Detection of a statistically significant deviation from isotropy in the burst distribution would provide a clue to the distance of the burst sources. BATSE's ability to detect slight deviations of the angular distribution from isotropy is, in part, dependent on the accuracy of the computed burst locations. Using bursts whose locations have been determined accurately and independently, we estimate BATSE's location uncertainties and incorporate them into 3D Monte Carlo simulations of the burst distributions to show that, despite individual burst location uncertainties of about 5 deg, the ability of BATSE to place stringent limits on the anisotropy present in the angular distribution of the gamma-ray bursts is not significantly degraded. Observational effects of possible galactic halo distributions of the burst sources are noted.
    Keywords: SPACE RADIATION
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 413; 1; p. 293-297.
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