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  • Animals  (4)
  • DOCUMENTATION AND INFORMATION SCIENCE  (3)
  • Enzymes  (2)
  • 1990-1994  (9)
  • 1
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    Generation and analysis of interleukin-4 deficient mice (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-11-01
    Description: Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuhn, R -- Rajewsky, K -- Muller, W -- New York, N.Y. -- Science. 1991 Nov 1;254(5032):707-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948049" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Alleles ; Animals ; B-Lymphocytes/immunology ; Blotting, Southern ; Chromosome Deletion ; Concanavalin A ; DNA/genetics/isolation & purification ; Female ; Interleukin-4/deficiency/*genetics ; Lymph Nodes/growth & development/immunology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Restriction Mapping ; Spleen/growth & development/immunology ; T-Lymphocytes/immunology ; Thymus Gland/growth & development/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Expression and activity of the POU transcription factor SCIP (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-09-14
    Description: POU proteins have been shown to transcriptionally active cell-specific genes and to participate in the determination of cell fate. It is therefore thought that these proteins function in development through the stable activation of genes that define specific developmental pathways. Evidence is provided here for an alternative mode of action. The primary structure of SCIP, a POU protein expressed by developing Schwann cells of the peripheral nervous system, was deduced and SCIP activity was studied. Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation. In cotransfection assays, SCIP acted as a transcriptional repressor of myelin-specific genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monuki, E S -- Kuhn, R -- Weinmaster, G -- Trapp, B D -- Lemke, G -- NS 23896/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1975954" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Differentiation/genetics ; Cloning, Molecular ; Cyclic AMP/physiology ; Gene Expression Regulation ; Gene Library ; Genes, Homeobox/genetics/*physiology ; Molecular Sequence Data ; Myelin Sheath/metabolism ; Nerve Tissue Proteins/genetics/*physiology ; Octamer Transcription Factor-6 ; Rats ; Repressor Proteins/genetics/*physiology ; Schwann Cells/*cytology/metabolism ; Transcription Factors/genetics/*physiology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    MHC class I expression in mice lacking the proteasome subunit LMP-7 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-08-26
    Description: Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fehling, H J -- Swat, W -- Laplace, C -- Kuhn, R -- Rajewsky, K -- Muller, U -- von Boehmer, H -- New York, N.Y. -- Science. 1994 Aug 26;265(5176):1234-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Basel Institute for Immunology, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8066463" target="_blank"〉PubMed〈/a〉
    Keywords: *ATP-Binding Cassette Transporters ; Amino Acid Sequence ; Animals ; Antigen Presentation ; Antigen-Presenting Cells/immunology ; Base Sequence ; Carrier Proteins/genetics ; *Cysteine Endopeptidases ; Female ; Gene Deletion ; H-2 Antigens/*biosynthesis/immunology ; H-Y Antigen/immunology ; Lymphocytes/immunology ; Male ; Mice ; Mice, Knockout ; Molecular Sequence Data ; *Multienzyme Complexes ; Proteasome Endopeptidase Complex ; Proteins/genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Resistance to murine acquired immunodeficiency syndrome (MAIDS) (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morawetz, R A -- Doherty, T M -- Giese, N A -- Hartley, J W -- Muller, W -- Kuhn, R -- Rajewsky, K -- Coffman, R -- Morse, H C 3rd -- New York, N.Y. -- Science. 1994 Jul 8;265(5169):264-6; author reply 267.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8023146" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/genetics/immunology ; Disease Susceptibility ; Immunity, Innate/genetics ; Interleukin-4/deficiency/genetics/*immunology ; Mice ; Mice, Inbred Strains ; Mice, Mutant Strains ; Mice, Transgenic ; Murine Acquired Immunodeficiency Syndrome/genetics/*immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Hypertext and hypermedia systems in information retrieval (1992)
    In:  CASI
    Details
    Publication Date: 2019-08-28
    Description: This paper opens with a brief history of hypertext and hypermedia in the context of information management during the 'information age.' Relevant terms are defined and the approach of the paper is explained. Linear and hypermedia information access methods are contrasted. A discussion of hyperprogramming in the handling of complex scientific and technical information follows. A selection of innovative hypermedia systems is discussed. An analysis of the Clinical Practice Library of Medicine NASA STI Program hypermedia application is presented. The paper concludes with a discussion of the NASA STI Program's future hypermedia project plans.
    Keywords: DOCUMENTATION AND INFORMATION SCIENCE
    Type: AGARD, Bringing Down the Barriers to Informations Transfer; 5 p
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Quo vadimus? The 21st Century and multimedia (1991)
    In:  CASI
    Details
    Publication Date: 2019-08-28
    Description: The concept is related of computer driven multimedia to the NASA Scientific and Technical Information Program (STIP). Multimedia is defined here as computer integration and output of text, animation, audio, video, and graphics. Multimedia is the stage of computer based information that allows access to experience. The concepts are also drawn in of hypermedia, intermedia, interactive multimedia, hypertext, imaging, cyberspace, and virtual reality. Examples of these technology developments are given for NASA, private industry, and academia. Examples of concurrent technology developments and implementations are given to show how these technologies, along with multimedia, have put us at the threshold of the 21st century. The STI Program sees multimedia as an opportunity for revolutionizing the way STI is managed.
    Keywords: DOCUMENTATION AND INFORMATION SCIENCE
    Type: NASA-TM-107563 , NAS 1.15:107563
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
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    Defense Technical Information Center (DTIC) - Its role in the USAF Scientific and Technical Information Program (1991)
    In:  Other Sources
    Details
    Publication Date: 2019-08-27
    Description: The Defense Technical Information Center (DTIC), the central repository for DOD scientific and technical information concerning studies and research and engineering efforts, is discussed. The present makeup of DTIC is described and its functions in producing technical reports and technical report bibliographies are examined. DTIC's outreach services are reviewed, as are its DTIC information and technology transfer programs. DTIC's plans for the year 2000 and its relation to the mission of the U.S. Air Force, including the Air Force's STINFO program, are addressed.
    Keywords: DOCUMENTATION AND INFORMATION SCIENCE
    Type: Government Information Quarterly (ISSN 0740-624X); 8; 2, 19
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
    Electronic Resource
    Electronic Resource
    Tn916-induced mutants of Clostridium acetobutylicum defective in regulation of solvent formation (1990)
    Springer
    Archives of microbiology 153 (1990), S. 373-377 
    Details
    ISSN: 1432-072X
    Keywords: Acetaldehyde dehydrogenase ; Alcohol dehydrogenase ; Clostridium acetobutylicum ; Enzymes ; Mutants ; Solvent formation ; Tn916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sixteen Tn916-induced mutants of Clostridium acetobutylicum were selected that were defective in the production of acetone and butanol. Formation of ethanol, however, was only partially affected. The strains differed with respect to the degree of solvent formation ability and could be assigned to three different groups. Type I mutants (2 strains) were completely defective in acetone and butanol production and contained one or three copies of Tn916 in the chromosome. Analysis of the mutants for enzymes responsible for solvent production revealed the presence of a formerly unknown, specific acetaldehyde dehydrogenase. The data obtained also strongly indicate that the NADP+-dependent alcohol dehydrogenase is in vivo reponsible for ethanol formation, whereas the NAD+-dependent alcohol dehydrogenase is probably involved in butanol production. No activity of this enzyme together with all other enzymes in the acetone and butanol pathway could be found in type I strains. All tetracycline-resistant mutants obtained did no longer sporulate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00249008
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Irreversible Desaktivierung von menschlicher β-Hexosaminidase A mit dem alkylierenden Pseudodisaccharid (3,4,6/5)-6-(2-Acetamido-2-desoxy-β-D-glucopyranosylthio)-3,4-epoxy-5-hydroxycyclohexenEs handelt sich hierbei um eine von zwei diastereomeren Verbindungen. Die absolute Konfiguration wurde nicht bestimmt. (1992)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1992 (1992), S. 407-409 
    Details
    ISSN: 0170-2041
    Keywords: Affinity labelling ; Epoxides ; β-Hexosaminidases ; Thioglycosides ; Enzymes ; Carbohydrates ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Irreversible Deactivation of Human β-Hexosaminidase A with the Alkylating Pseudodisaccharide (3,4,6/5)-6-(2-Acetamido-2-deoxy-β-D-glucopyranosylthio) -3,4-epoxy-5-hydroxycyclohexene(3,4,6/5)-6-(2-Acetamido-2-deoxy-β-D-glucopyranosylthio)-3,4-epoxy-5-hydroxycyclohexene (8b) has been synthesised and found to deactivate irreversibly human β-D-hexosaminidase from lysosomes. Deactivation did not take place in the presence of the competitive inhibitor (3,6/4,5)-6-(2-acetamido-2-deoxy-β-D-glucopyranosylthio)-4-bromo-3,5-dihydroxy-cyclohexene (5a/b).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199219920172
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