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  • Source  (4)
  • JGR  (2)
  • *Trans-Activators  (1)
  • Bone mineral analysis  (1)
  • Bone strength  (1)
  • 1990-1994  (9)
  • 1
    Publication Date: 1992
    Keywords: Proceedings of a conference ; Earthquake precursor: prediction research ; Source ; Seismology
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  • 2
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    In:  Phys. Earth Plan. Int., Washington, D.C., AGU, vol. 61, no. 3, pp. 269-290, pp. 1047, (ISSN: 1340-4202)
    Publication Date: 1990
    Keywords: Seismology ; Source ; Source mechanics ; Subduction zone ; PEPI
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  • 3
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    In:  Geophys. Res. Lett., Warszawa, AGU, vol. 17, no. 6951, pp. 1001-1004, pp. 2091, (ISSN: 1340-4202)
    Publication Date: 1990
    Keywords: Earthquake ; Source parameters ; Source ; Stress ; Fracture ; Stress drop ; GRL
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  • 4
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    In:  J. Geophys. Res., Warszawa, AGU, vol. 98, no. 6951, pp. 2017-2037, pp. 2091, (ISSN: 1340-4202)
    Publication Date: 1993
    Keywords: Seismology ; Subduction zone ; Hypocentral depth ; JGR
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  • 5
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    In:  J. Geophys. Res., Warszawa, AGU, vol. 96, no. 6951, pp. 11997-12022, pp. 2091, (ISSN: 1340-4202)
    Publication Date: 1991
    Keywords: Subduction zone ; Seismology ; JGR
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  • 6
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    In:  Eos, Trans., Am. Geophys. Un., Kunming, China, AGU, vol. 74, no. 34, pp. 377, pp. 2211, (ISSN: 1340-4202)
    Publication Date: 1993
    Keywords: Earthquake ; Source
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  • 7
    Publication Date: 1993-09-24
    Description: Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF. Administration of interferon-gamma (IFN-gamma) resulted in the appearance in liver nuclei of two tyrosine phosphorylated proteins (84 and 91 kilodaltons). The 84- and 91-kilodalton proteins detected after either EGF or IFN-gamma administration were identified as the IFN-gamma activation factors (GAF). Furthermore, gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN-gamma administration, specifically bound to the sis-inducible element of the c-fos promoter. Thus, GAF proteins participate in nuclear signaling in both IFN-gamma and EGF pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruff-Jamison, S -- Chen, K -- Cohen, S -- HD-00700/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1993 Sep 24;261(5129):1733-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8378774" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Nucleus/drug effects/*metabolism ; DNA-Binding Proteins/*metabolism ; Epidermal Growth Factor/*pharmacology ; Genes, fos ; Interferon-Stimulated Gene Factor 3 ; Interferon-gamma/*pharmacology ; Liver/drug effects/metabolism ; Mice ; Molecular Sequence Data ; Phosphorylation ; Promoter Regions, Genetic ; STAT1 Transcription Factor ; *Trans-Activators ; Transcription Factors/*metabolism ; Tyrosine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    ISSN: 1432-0827
    Keywords: Bone mineral analysis ; Hip strength analysis ; Age ; Femoral neck stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The greater hip fracture rate among elderly women is generally ascribed to differences in femoral neck strength between the sexes. Strength of a given bone is a function of both its material properties and the magnitudes of mechanical stresses within it. This study examined the hypothesis that these apparent strength differences between the sexes are due to dissimilarities in the restructuring of the femoral neck with age, which result in higher stresses in elderly women. Using Hip Strength Analysis, a computer program developed by the authors, femoral neck cross-sectional geometric properties for stress analyses were derived from bone mineral image data of 409 community living, white subjects ranging from 19 to 93 years of age. Though both sexes show declines in femoral neck bone mineral density (BMD) and cross-sectional area with age, only females show a decline in the cross-sectional moment of inertia (CSMI, a geometric index of bone rigidity). The lack of decline in male CSMI appears to be a result of a small but significant increase in femoral neck girth. Similar age-related changes have been observed in the femoral shaft by others. The net effect of these observed changes is that mechanical stresses in the femoral neck of females appear to increase at three times the rate per decade of those of males. These results lend support to the hypothesis that the higher fracture rate in elderly women is due, at least in part, to elevated levels of mechanical stress, resulting from a combination of greater bone loss and less compensatory geometric restructuring with age.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 53 (1993), S. S41 
    ISSN: 1432-0827
    Keywords: Female femoral neck ; Bone strength ; Structural geometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Bone strength is a function of both bone mass and its geometric distribution, a factor that is obscured in the conventional bone mineral analysis. Structural geometry is particularly important in areas such as the femoral neck that are exposed to bending loadsin vivo. Here we present results of a study examining age changes in the structural geometry of the female femoral neck derived from dual photon absorptiometry (DPA) data. In a previous study, differences in the aging patterns of males and females over the entire adult age range were demonstrated. In that study, only males showed “compensatory” geometric restructuring of the femoral neck which tended to offset loss of bone mineral with age. In the present study, femoral neck structural properties from 1044 women were examined for aging trends before and after the approximate age of menopause (50 years). Women in the premenopausal age range showed a 4% decline per decade in femoral neck BMD, but no change in the femoral neck cross-sectional moment of inertia (CSMI). This aging pattern is similar to that of males in our earlier study, and in both cases resulted in little or no increase in femoral neck bending stresses. After age 50, however, women show a more rapid decline in femoral neck BMD (7% per decade) accompanied by a decline in CSMI of 5% per decade. These changes result in increases in femoral neck stresses of 4–12% per decade due to the apparent lack of compensatory restructuring to offset the loss of bone mineral. These results shed further light on the age-related mechanisms underlying sex differences in fracture incidence among the elderly. They also argue for the routine use of such structural analyses in any study of age-related osteopenia or the effects of therapeutic intervention on this condition.
    Type of Medium: Electronic Resource
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