Publication Date:
1994-10-21
Description:
Assembly of antigen receptor V (variable), D (diversity), and J (joining) gene segments requires lymphocyte-specific genes and ubiquitous DNA repair activities. Severe combined immunodeficient (SCID) mice are defective in general double-strand (ds) DNA break repair and V(D)J coding joint formation, resulting in arrested lymphocyte development. A single treatment of newborn SCID mice with DNA-damaging agents restored functional, diverse, T cell receptor beta chain coding joints, as well as development and expansion of thymocytes expressing both CD4 and CD8 coreceptors, but did not promote B cell development. Thymic lymphoma developed in all mice treated with DNA-damaging agents, suggesting an interrelation between V(D)J recombination, dsDNA break repair, and lymphomagenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Danska, J S -- Pflumio, F -- Williams, C J -- Huner, O -- Dick, J E -- Guidos, C J -- New York, N.Y. -- Science. 1994 Oct 21;266(5184):450-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Surgical Research, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7524150" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
B-Lymphocytes/cytology/immunology
;
Base Sequence
;
Bleomycin/pharmacology
;
Cell Transformation, Neoplastic
;
*DNA Damage
;
DNA Repair
;
Gamma Rays
;
*Gene Rearrangement
;
Hematopoietic Stem Cells/cytology/immunology
;
Lymphoma/etiology/pathology
;
Mice
;
Mice, SCID
;
Molecular Sequence Data
;
Receptors, Antigen, T-Cell, alpha-beta/*genetics
;
T-Lymphocyte Subsets/cytology/immunology
;
T-Lymphocytes/cytology/*immunology
;
Thymus Neoplasms/etiology/pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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