ISSN:
0749-1581
Keywords:
Assignment of relative configurations
;
1H and 13C NMR
;
conformational study
;
Acyclic diastereomeric ketones
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The conformational analysis and the assignment of relative configurations [(RR, SS) and (RS, SR)] to the dia-stereomeric racemates of two acyclic ketones with two asymmetric carbons, ±-2,2,7,7-tetramethyl-5,6-diphenyloctan-3-one and ±-5,5-dimethyl-1,3,4-triphenylhexan-1-one, have been achieved by analysis of1H-1H geminal and vicinal coupling constants, 13C-1H direct coupling constants and 13C chemical shifts. This study allows the establishment of the monoconformational character of the (RR, SS) diastereomers. The application of the empirical equation of Haasnoot et al. supports this hypothesis.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260280711
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