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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the thyroid in transgenic mice expressing the genes for human and bovine growth hormone (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 1043-1046 
    Details
    ISSN: 1420-9071
    Keywords: Thyroid ; transgenic mouse ; human growth hormone ; thyroid hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The thyroid glands of transgenic mice (TM) expressing the genes for human (h) and bovine (b) growth hormone (GH) were studied. The percentages of larger follicles inhGH TM of either sex were significantly greater than in the corresponding normal littermates, and follicles ranging up to 350 μm in diameter were present in malehGH TM. In contrast, thyroid follicles were only slightly enlarged in malebGH TM, and were unchanged in femalebGH TM. The serum concentrations of T4 were significantly decreased in malebGH TM and not altered in the other groups. Serum concentrations of T3 were slightly, but significantly increased in femalehGH TM and femalebGH TM, but were unaffected in male TM of either type. Since the principal difference between these foreign GHs in rodents is the additional lactogenic activity of human GH, these results may indicate that the effects of prolactin can influence the development of the thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940668
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  • 2
    Electronic Resource
    Electronic Resource
    On the L 1 convergence of kernel estimators of regression functions with applications in discrimination (1980)
    Springer
    Probability theory and related fields 51 (1980), S. 15-25 
    Details
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary An estimate m n of a regression function m(x)=E{Y|X=x} is weakly (strongly) consistent in L 1 if ∝¦m n (x)-m(x)¦μ(dx) converges to 0 in probability (w.p. 1) as the sample size grows large (μ is the probability measure of X). We show that the well-known kernel estimate (Nadaraya, Watson) and several recursive modifications of it are weakly (strongly) consistent in L 1 under no conditions on (X, Y) other than the boundedness of Y and the absolute continuity of μ. No continuity restrictions are put on the density corresponding to μ. We further notice that several kernel-type discrimination rules are weakly (strongly) Bayes risk consistent whenever X has a density.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00533813
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of UAS elements and binding proteins necessary for derepression of Saccharomyces cerevisiae fructose-1,6-bisphosphatase (1992)
    Springer
    Current genetics 22 (1992), S. 363-370 
    Details
    ISSN: 1432-0983
    Keywords: Saccharomyces cerevisiae ; Fructose-1,6-bisphosphatase ; Glucose repression ; Gene activation ; Gluconeogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Fructose-1,6-bisphosphatase is a key enzyme in gluconeogenesis and the FBP1 gene is not transcribed during growth with glucose. Genetic analysis indicated a positive regulation of FBP1 expression after exhaustion of glucose. By linker-deletion analysis, two upstream activation sites (UAS1 and UAS2) were localized and the respective UAS-binding factors (DAP I and DAP II for derepression activating protein) were identified by gel retardation. UAS1 and UAS2 span about 30 bp each, and are separated by approximately 30 bp. Both UAS sites act synergistically. Although UAS1 showed some similarities to the DNA-binding consensus for the general yeast activator Rap1, competition experiments and DEAE-chromatography proved that DAP I and Rap1 correspond to different proteins. Gel retardation by DAP I depended on carbon sources and did not occur in cells growing logarithmically with glucose, whereas a strong retardation signal was obtained with ethanol-grown cells. The present results suggest that DAP I and DAP II are the final regulatory elements for glucose derepression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352437
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of cyclophosphamide administered after total body irradiation of bone marrow transplant recipients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 521-523 
    Details
    ISSN: 1432-1041
    Keywords: Cyclophosphamide ; Pharmacokinetics ; 4-Hydroxycyclophosphamide ; Bone marrow Transplantation ; Total body irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary High-dose cyclophosphamide is used immediately after total body irradiation (TBI) in conditioning for bone marrow transplantation (BMT). Possible interactions of the two treatment modalities were sought by measuring the blood pharmacokinetics of CP and 4-hydroxy-cyclophosphamide (4-HOCP) in patients undergoing BMT. There was a non-significant trend to a shorter half-life of CP compared to reported values. Exposure to 4-HOCP, the major metabolite of CP, did not appear to be altered by prior TBI of the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315233
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  • 5
    Electronic Resource
    Electronic Resource
    The marine bacterium Alteromonas espejiana induces metamorphosis of the hydroid Hydractinia echinata (1993)
    Springer
    Marine biology 115 (1993), S. 173-178 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The marine hydroid Hydractinia echinata develops into a primary polyp from a planula larva stage. The planula does not undergo metamorphosis in sterile filtered seawater. Metamorphosis is induced by certain bacteria occurring, as a rule, on the shells of molluscs inhabited by hermit crabs of the genus Eupagurus. Bacteria were isolated from shells occupied by H. echinata, and bacterial clones were selected which had a strong potency for inducing metamorphosis in planula larvae. One such clone was further subcloned for strong metamorphosis-inducing potency and finally investigated for inductive characteristics and for identification purposes. The bacterium is a motile, aerogen, gram-negative rod with a polar flagellum. It was identified on the basis of several physiological characteristics as a strain of the genus Alteromonas espejiana. The ability to induce metamorphosis might not be restricted to A. espejiana. The inhibitor of protein kinase C, sphingosine, inhibited metamorphosis induced by A. espejiana. The metamorphosis-inducing principle is likely to be a lipid, since upon lipid extraction and separation of different lipid classes by solid phase extraction on silica-aminopropyl columns a metamorphosis-inducing fraction was obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346332
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  • 6
    Electronic Resource
    Electronic Resource
    Pressure and temperature dependence of the electric field gradient (EFG) in CdS (1992)
    Springer
    The European physical journal 87 (1992), S. 61-63 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using the time differential perturbed angular correlation technique (TDPAC), the electric hyperfine interaction of111Cd in the II-VI-semiconductor CdS was investigated. The results of the temperature and pressure dependence of the electric field gradient (EFG) are discussed. The binding energyE b for111In at a Cd lattice site and a Cd vacancy (111InCd−VCd−pair) could be estimated to 340 meV±80 meV by means of an Arrhenius-Plot. The disappearance of the 79 MHz and 73 MHz frequencies under a pressure of about 30 kbar could be due to their vacancy character or to the beginning of the phase transition to rocksalt structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01308257
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  • 7
    Electronic Resource
    Electronic Resource
    Mortality factors of satin moth,Leucoma salicis [Lep.: Lymantriidae], in aspen forests in Maine (1980)
    Springer
    BioControl 25 (1980), S. 7-16 
    Details
    ISSN: 1573-8248
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Les agents de mortalité naturelle du Bombyx du saule,Leucoma salicis (L.) ont été étudiés dans deux peuplements dePopulus grandidentata Michaux. La plus forte mortalité est intervenue chez les larves hivernantes. Elle a été provoquée par 2 champignons,Paecilomyces sp. etHirsutella gigantea Petch., un facteur paraissant être un agent pathogène d'après les symptômes, le parasiteEupteromalis hemipterus (Walker) et des causes inconnues. La mortalité parPaecilomyces etE. hemipterus fut diminuée dans les sites d'hibernation recouvert d'une toile d'emballage. Les parasites issus des larves et des chrysalides furent: les braconidesApanteles melanoscelus (Ratzeburg) etMeteorus versicolor (Wesmeal), l'ichneumonideCoccygomimus pedalis (Cresson), les tachinairesCompsilura concinnata (Meigen),Carcelia laxifrons Villeneuve,Tachinomyia variata Curran, et les sarcophagidesSarcophaga aldrichi Parker etAgria housei Shewell. les prédateurs des larves et des chrysalides comprenaient le carabiqueCalosoma frigidum Kirby, des pentatomides et des oiseaux notamment le coucou,Coccyzus erythrophthaimus (Wilson). Les œufs furent parasités par le scelionideTelenomus probablementcalifornicus Ashmead et le trichogranneTrichogramma minutum (Riley). Parmi les prédateurs des papillons il y avait la grive,Hylocichla guttata (Pallas) et des pentatomides.
    Notes: Abstract Natural control agents of the satin moth,Leucoma salicis (L.) were examined in 2Populus grandidentata Michaux stands. Highest mortality occurred in overwintering larvae, with the causal agents 2 fungi,Paecilomyces sp. andHirsutella gigantea Petch, a factor causing death symptomatic of a pathogen, the parasiteEupteromalis hemipterus (Walker) and death from unknown causes. Mortality fromPaecilomyces sp. andE. hemipterus was reduced where overwintering sites were covered with burlap cloth. Parasites recovered from larvae and pupae included the braconidsApanteles melanoscelus (Ratzeburg) andMeteorus versicolor (Wesmeal), the ichneumonidCoccygomimus pedalis (Cresson), the tachinidsCompsilura concinnata (Meigen),Carcelia laxifrons Villeneuve,Tachinomyia variata Curran, and the sarcophagidsSarcophaga aldrichi Parker andAgria housei Shewell. Larval and pupal predators included the carabidCalosoma frigidum Kirby, pentatomids, and birds, particularly black-billed cuckoos,Coccyzus erythrophthaimus (Wilson). Eggs were parasitized by the scelionidTelenomus prob.californicus Ashmead and the trichogrammidTrichogramma minutum (Riley). Predators of adult satin moths included the hermit thrush,Hylocichla guttata (Pallas), and pentatomid bugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02377517
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  • 8
    Electronic Resource
    Electronic Resource
    Impact of foraging byMonochamus titillator [Col.: Cerambycidae] on within-tree populations ofDendroctonus frontalis [Col.: Scolytidae] (1980)
    Springer
    BioControl 25 (1980), S. 155-170 
    Details
    ISSN: 1573-8248
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé L’impact de l’activité deMonochamus titillator (Fab.) sur les populations à l’intérieur de l’arbre deDendroctonus frontalis Zimm. est décrit. Le total des évaluations de population deD. frontalis dans des zones à l’intérieur du tronc attaquées parM. titillator a été soumis à l’ordinateur pour 89 pins,Pinus taeda L., échantillonnés pendant 3 ans. Les histogrammes de fréquence ont été établis pour la surface de l’habitat infesté, la surface explorée parM. titillator et pour les populations deD. frontalis présentes dans l’arbre. A partir de ces données on a calculé la part de surface utilisée parM. titillator, la mortalité deD. frontalis extrapolée pour l’arbre entier et la mortalité se produisant dans la surface exploitée. Les histogrammes traduisant les variations de ces composantes ont été dressés en ayant recours à des modèles mathématiques non linéaires. Environ 20% de la surface infestée a été exploitée parM. titillator; la mortalité du scolyte fut d’environ 14% dans l’arbre et de 70% dans la zone attaquée parM. titillator. Ces évaluations sont très variables d’un arbre à l’autre et on a mis au point un procédé pour prévoir la probabilité d’un taux donné d’activité alimentaire du cerambycide et de mortalité du scolyte. Les causes de cette variabilité ont été étudiées. La variation suivant les années et les saisons suit les mêmes tendances à savoir l’augmentation à la fois de l’activité alimentaire et de la mortalité de la base au sommet du pin attaqué. La variation selon les classes de taille des arbres est hautement significative: les arbres les plus gros présentent une exploitation et une mortalité beaucoup plus importantes que les arbres plus petits. La mortalité du scolyte dans la zone attaquée par le cerambycide est également plus élevée aux extrémités du pin infesté.
    Notes: Abstract The impact of foraging byMonochamus titillator (Fab.) on within-tree populations ofDendroctonus frontalis Zimm. was described. Total population estimates forD. frontalis and inner bark area foraged byM. titillator were computed for 89 loblolly pine,Pinus taeda L., sampled over a 3 year period. Frequency histograms were prepared for the surface area of habitat infested, area foraged byM. titillator, and within-tree populations ofD. frontalis. These data were used to calculate the proportion of area foraged byM. titillator, the proportionalD. frontalis mortality for the entire tree, and the proportional mortality occurring in the foraged area. Histograms showing the variation of these components were prepared and described using nonlinear mathematical models. Ca. 20% of the infested surface area was foraged byM. titillator. Mortality toD. frontalis on a per tree basis was ca. 14%. Mortality in the area foraged byM. titillator was ca. 70%. These estimates were highly variable between individual trees and a procedure for predicting the probability of a given level of foraging and mortality was described. Sources of variation influencing foraging byM. titillator and mortality toD. frontalis were investigated. Variation between years and season followed similar trends with both foraging and mortality increasing from the base to the top of the infested bole. Variation between tree size-class was highly significant. Larger size-class trees had substantially greater foraging and mortality than did the smaller size-classes. Mortality within the foraged area was also found to be greater at the extremes of the infested bole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374317
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  • 9
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    Studies on the thyroid in transgenic mice expressing the genes for human and bovine growth hormone (1990)
    Springer
    Details
    Publication Date: 1990-10-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 10
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    Pressure and temperature dependence of the electric field gradient (EFG) in CdS (1992)
    Springer
    Details
    Publication Date: 1992-02-01
    Print ISSN: 0722-3277
    Electronic ISSN: 1431-584X
    Topics: Physics
    Published by Springer
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