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  • Artikel  (69)
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  • 1
    ISSN: 1436-5073
    Schlagwort(e): FTIR ; rapid-scan ; thermal analysis ; nitrate salts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A new experiment is described to advance the mechanistic description of fast thermal decomposition chemistry related to preignition and ignition. The technique is illustrated with data for ethylenediammonium dinitrate which displays separable thermochemical events in the condensed phase that correlate with the nature of the products evolved to the gas phase.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Marine geophysical researches 13 (1991), S. 287-309 
    ISSN: 1573-0581
    Schlagwort(e): SeaMARC II ; side-scan ; bathymetry ; magnetics microplates ; rift propagation ; East Pacific Rise
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract The Pito Rift area is the site of actively deforming oceanic lithosphere that has been primarily under extension for at least the past million years, based on kinematic reconstructions. The major morphologic features, Pito Deep and Pito Seamount, are aligned toward the Euler pole for relative motion between the Easter and Nazca plates. SeaMARC II side-scan and bathymetry data indicate that there are two general modes of faulting currently active in the Pito Rift area. One is associated with incipient rifting of old (∼3 Ma) Nazca lithosphere by large NW-SE normal faults, and the other is associated with a broad area of right-lateral transform shear between the Nazca and Easter plates. This transform shear is distributed over a broad region because of the northward growth of the East Rift and parallel tectonic rifting within the Pito Rift area. The majority of the Pito Rift area is composed of preexisting blocks of Nazca plate that are back-tilted away from Pito Deep and strike perpendicular to present and previous relative plate motions. This observation suggests that block-faulting and back-tilting are the primary mechanisms responsible for the distributed lithospheric extension, in agreement with gravity and magnetic analyses (Martinez et al., this issue). The only recent volcanic flows observed in side-scan data are from the Pito Seamount area and to the outside of the outer pseudofault of the East Rift. The significance of the young flows near the outer pseudofault is not understood. We interpret the flows extending northwest from the Pito Seamount as representing a newly formed seafloor spreading axis within the Pito Rift area. Gravity and magnetic analyses (Martinez et al., this issue) together with SeaMARC II bathymetry and side-scan data support this interpretation. Based on the tectonic evolution of the Easter microplate, we propose an evolutionary model for the formation of the Pito Rift area, where new ‘tectonic’ grabens form immediately west of the previous graben and with slightly more counterclockwise orientation. The duration and history of tectonic activity for each graben are not well constrained.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    ISSN: 1573-0581
    Schlagwort(e): Magnetic inversion ; Bouguer anomalies ; block faulting ; modelling ; microplate ; rift propagation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract We present results from a SeaMARC II bathymetry, gravity, and magnetics survey of the northern end of the large-offset propagating East Rift of the Easter microplate. The East Rift is offset by more than 300 km from the East Pacific Rise and its northern end has rifted into approximately 3 Ma lithosphere of the Nazca Plate forming a broad (70–100 km) zone of high (up to 4 km) relief referred to as the Pito Rift. This region appears to have undergone distributed and asymmetric extension that has been primarily accommodated tectonically, by block faulting and tilting, and to a lesser degree by seafloor spreading on a more recently developed magmatic accretionary axis. The larger fault blocks have dimensions of 10–15 km and have up to several km of throw between adjacent blocks suggesting that isostatic adjustments occur on the scale of the individual blocks. Three-dimensional terrain corrected Bouguer anomalies, a three-dimensional magnetic inversion, and SeaMARC II backscatter data locate the recently developed magmatic axis in an asymmetric position in the western part of the rift. The zone of magmatic accretion is characterized by an axis of negative Bouguer gravity anomalies, a band of positive magnetizations, and a high amplitude magnetization zone locating its tip approximately 10 km south of the Pito Deep, the deepest point in the rift area. Positive Bouguer gravity anomalies and negative magnetizations characterize the faulted area to the east of the spreading axis supporting the interpretation that this area consists primarily of pre-existing Nazca plate that has been block faulted and stretched, and that no substantial new accretion has occurred there. The wide zone of deformation in the Pito Rift area and the changing trend of the fault blocks from nearly N-S in the east to NW-SE in the west may be a result of the rapidly changing kinematics of the Easter microplate and/or may result from ridge-transform like shear stresses developed at the termination of the East Rift against the Nazca plate. The broad zone of deformation developed at the Pito Rift and its apparent continuation some distance south along the East Rift has important implications for microplate mechanics and kinematic reconstructions since it suggests that initial microplate boundaries may consist in part of broad zones of deformation characterized by the formation of lithospheric scale fault blocks, and that what appear to be pseudofaults may actually be the outer boundaries of tectonized zones enclosing significant amounts of stretched pre-existing lithosphere.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Theoretical chemistry accounts 72 (1987), S. 475-484 
    ISSN: 1432-2234
    Schlagwort(e): Desorption ; Phonons ; Thermal
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A model for one-phonon thermal desorption is presented in which the structure of the substrate phonons, expressed as a projection on a surface atom of the phonon density of states, appears as a separate factor in the angle- and energy-resolved desorption rate. Desorption from both localized, and delocalized initioladatom states is considered. Under certain circumstances one can obtain the cosine-distribution of the equilibrium theory, but in general, the desorption flux from delocalized states deviates from the cosine law by being peaked away from the surface normal, whereas for localized initiol states, the flux is concentrated more in the normal direction.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Molecular and cellular biochemistry 117 (1992), S. 63-70 
    ISSN: 1573-4919
    Schlagwort(e): glycogen phosphorylase ; alloxan-diabetes ; cardiomyocytes ; G-protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract The basis for the hypersensitive response of glycogen phosphorylase to epinephrine stimulation was investigated in adult rat cardiomyocytes isolated from normal and alloxan-diabetic animals. To assess potential G-protein involvement in the response, normal and diabetic derived myocytes were incubated with either cholera or pertussis toxin prior to hormonal stimulation. Pretreatment of cardiomyocytes with cholera toxin resulted in a potentiated response to epinephrine stimulation whereas pertussis toxin did not affect the activation of this signaling pathway. To determine if the enhanced response of phosphorylase activation resulted from an alteration in adenylate cyclase activation, the cells were challenged with forskolin. After 3 hr in primary culture, diabetic cardiomyocytes exhibited a hypersensitive response to forskolin stimulation relative to normal cells. However, after 24 hr in culture, both normal and diabetic myocytes responded identically to forskolin challenge. The present data suggest that a cholera toxin sensitive G-protein mediates the hypersensitive response of glycogen phosphorylase to catecholamine stimulation in diabetic cardiomyocytes and this response which is present in alloxan-diabetic cells and is induced in vitro in normal cardiomyocytes is primarily due to a defect at a post-receptor site.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    ISSN: 1573-4919
    Schlagwort(e): cardiomyocytes ; SV40 large T antigen ; retroviral infection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Freshly isolated ventricular myocytes have been used extensively as an adult cardiac model system. Due to their inability to undergo cytokinesisin vitro and their dedifferentiated properties in long-term culture, they can not be used for extended studies. Recent reports tell of the establishment of fetal and neonatal cardiac cell lines and the development of adult cardiomyocytes from transgenic animals. A recent report by Kirshenbaum [1], is the first to demonstrate insertion of genes in to adult ventricular myocytes using viral infection. This paper discusses the infection of primary adult differentiated cardiomyocytes with the SV40 large T antigen and subsequent proliferation under temperature sensitive control. Upon further characterization, the cells could be used as a model to study muscle differentiation and repair as well as adult cardiac cell physiology.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Molecular and cellular biochemistry 101 (1991), S. 167-174 
    ISSN: 1573-4919
    Schlagwort(e): rat protein phosphatase 2A ; liver ; heart ; diabetes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Summary Protein phosphatase 2A1 was purified from rat skeletal muscle and used to produce antisera to the three subunits of the holoenzyme. Affinity purified antibodies specific for the subunits of the phosphatase enzyme were found to recognize the type 2A1 and 2A2 phosphatase from rat skeletal muscle, heart, liver, brain and erythrocytes and were used to investigate the effects of diabetes on the levels of this enzyme in liver and heart. Phosphorylase phosphatase assays coupled with immunoblot analysis of fractionated rat liver and heart cytosol from normal and diabetic animals show no apparent differences in the quantity or activity of these enzymes following the induction of alloxan diabetes. When considering these results and the normal physiological concentrations of known effectors of these enzymes, it is likely that protein phosphatase 2A1 and 2A2 are not responsible for the dephosphorylation of phosphorylase a under physiological conditions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Fresenius' Zeitschrift für analytische Chemie 349 (1994), S. 257-258 
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Cluster Analysis has been shown to be partially suitable for the classification of glasses. The expansion of the clusters on the Seger's diagram allows an investigation of the influence of the different glass components. Variation of the SiO2 content results in a smaller change of properties than variation of the Na2O/RO relationship. Principal Component Analysis is convenient for showing correlations between the composition of the examined glasses, the glass structure parameters, and the different electrode properties.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Investigational new drugs 7 (1989), S. 189-193 
    ISSN: 1573-0646
    Schlagwort(e): doxorubicin ; iproplatin ; breast cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Forty-eight patients with advanced breast cancer were treated in a disease-specific phase I trial of doxorubicin and iproplatin combination chemotherapy. The doses of doxorubicin ranged between 30 and 50 mg/m2, and the doses of iproplatin ranged between 150 and 250 mg/m2. Myelosuppression was observed at all levels, but was dose-limiting at the highest level. In addition, nausea, diarrhea and malaise were prominent toxicities. Neither cardiac nor renal toxicity was encountered. Nine of 26 (35%) of previously untreated patients, and 5 of 22 (23%) previously treated patients demonstrated partial or complete responses. Although this combination possesses therapeutic activity, given its toxicities, further evaluation of doxorubicin in combination with iproplatin is not recommended.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    ISSN: 1573-0646
    Schlagwort(e): breast cancer ; Iproplatin ; CHIP ; phase II study
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Twenty-five women with advanced breast cancer were treated in a phase II trial of iproplatin 275 mg/m2 administered intravenously every 4 weeks. All patients had measurable or evaluable indicator lesions, and had undergone treatment with no more than one previous chemotherapy regimen, including adjuvant chemotherapy. Two of the twenty-four evaluable patients (8%) experienced major therapeutic responses. One patient had a complete regression of pulmonary nodules lasting 18 + months; another had a partial regression of metastatic disease in the liver (4 months). The inevaluable patient was ineligible for the study because of previous radiation to the indicator lesions on her chest wall; nonetheless, she experienced a 10 month partial regression of those nodules. Myelosuppression was generally dose limiting; thrombocytopenia was more profound, but leukopenia was more prolonged. Nausea, vomiting, diarrhea, and general malaise were prominent toxicities, and led to discontinuation of therapy in 4 patients. Iproplatin has limited activity in previously treated women with advanced breast cancer.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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