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  • Books
  • Articles  (6)
  • Physical Chemistry  (4)
  • Bone Gla protein  (2)
  • 1990-1994  (2)
  • 1985-1989  (4)
  • 1935-1939
Collection
  • Books
  • Articles  (6)
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  • 1990-1994  (2)
  • 1985-1989  (4)
  • 1935-1939
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  • 1
    Electronic Resource
    Electronic Resource
    The effect of a new vitamin D analog, 22-oxa-1α,25(OH)2D3, on bone mineral metabolism in normal male rats (1992)
    Springer
    Calcified tissue international 50 (1992), S. 521-523 
    Details
    ISSN: 1432-0827
    Keywords: 22-oxa-1α, 25 Dihydroxyvitamin D3 ; 1,25(OH)2D3 ; Bone histomorphometry ; Bone Gla protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Thein vivo effects of 22-oxa-1α, 25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P〈0.05) and decreased serum parathyroid hormone (PTH) (P〈0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P〈0.05) compared with controls. Lowdose OCT decreased serum PTH at all the time points (P〈0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582166
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of change of cancellous bone volume with short-term use of the new immunosuppressant rapamycin in rats (1993)
    Springer
    Calcified tissue international 53 (1993), S. 45-52 
    Details
    ISSN: 1432-0827
    Keywords: Rapamycin ; Bone mineral metabolism ; Bone Gla protein ; Immunosuppressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Immunosuppressants have adverse effects on bone mineral metabolism in animal and human studies, with corticosteroids producing low-turnover osteopenia, and cyclosporin-A (CsA) producing high-turnover osteopenia. Rapamycin (RAPA) is a new immunosuppressant reported to be at least 10 times more potent than CsA, and acts via a different pathway to CsA and the other new immunosuppressant FK506. This study investigated the effects of RAPA on bone mineral metabolism in the rat. Forty-two, 10-week-old, male Sprague Dawley rats were divided into three groups, and treated according to the following protocol: group A (control) received RAPA vehicle by daily gavage for 14 days (n = 12); group B (high dose RAPA) received RAPA 2.5 mg/kg/day by daily gavage for 14 days (n = 15); group C (low dose RAPA) received RAPA 1.25 mg/kg/day by daily gavage for 14 days (n = 15). Rats were weighed and bled on days 0, 7, and 14 for measurement of blood ionized calcium, bone Gla protein (BGP), parathyroid hormone (PTH), and 1,25(OH)2D. Tibial bone histomorphometry was determined on day 14 after double-calcein labeling. Weight gain was similar in the two groups treated with RAPA compared with control animals. High-dose RAPA (group B) transiently depressed serum BGP levels on day 7, with elevated blood ionized calcium levels on day 7, and lowered 1,25(OH)2D levels on day 14. Serum PTH levels were unchanged. Low dose RAPA (group C) did not affect calciotropic hormones. Histomorphometric analyses of tibial metaphyses revealed that parameters of bone formation and resorption were not significantly different in the groups treated with RAPA (group B and C) compared with control animals (group A). Trabecular bone volume (BV/TV) in group B (high-dose RAPA) (15.39 ± 1.01%) and C (low-dose RAPA) (15.38 ±0.57%) was not significantly altered compared with group A (control) (16.42 ± 0.86%). Short-term treatment with RAPA, unlike CsA, does not result in excess resorption and loss of bone volume. The depressed serum 1,25(OH)2D levels seen with high-dose RAPA therapy may adversely effect bone mineral metabolism in the long term.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01352014
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  • 3
    Electronic Resource
    Electronic Resource
    Model study of synchronization and other phenomena in light perturbation of the Briggs-Rauscher reaction (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 345-354 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Calculations are performed to model several phenomena observed when a photosensitive oscillating chemical reaction, the Briggs-Rauscher (BR) reaction, is subject to irradiation in a continuous-flow stirred-tank reactor. The BR mechanism proposed earlier by De Kepper and Epstein is supplemented by additional steps involving the photogeneration and subsequent reaction of iodine atoms. The calculations show qualitative agreement with the following experimentally observed phenomena: (a) change in the period and amplitude of oscillation as a function of the intensity of constant illumination, (b) synchronization between periodically varying illumination and the period of chemical oscillation, (c) phase shifts induced by single light pulses, and (d) dark steady states which are excitable by single light pulses and become oscillatory at appropriate levels of constant illumination.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170311
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  • 4
    Electronic Resource
    Electronic Resource
    Complex dynamical behavior in a new chemical oscillator: The chlorite-thiourea reaction in a CSTRPart 25 in the series Systematic Design of Chemical Oscillators. (Part 24: E. Kumpinsky and I. R. Epstein, J. Chem. Phys., in press.) (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 429-439 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction between chlorite ion and thiourea has been studied both in a closed (batch) system and in a flow reactor (CSTR). The principal stoichiometry is given by \documentclass{article}\pagestyle{empty}\begin{document}$$ 2{\rm ClO}_{\rm 2} ^{\rm - } + {\rm CS(NH}_{\rm 2} {\rm)}_{\rm 2} + {\rm 2NH}_{\rm 4} ^ + + {\rm CO}_{\rm 2} + 2{\rm Cl}^{\rm - } + {\rm SO}_{\rm 4} ^{{\rm 2 - }} $$\end{document} In batch, the reaction displays an induction period, whose length is proportional to [CS(NH2)2]/[ClO2-] [H+], followed by the rapid buildup and disappearance of a ClO2 intermediate. At [ClO2-]/[CS(NH2)2] ratios between 2.5 and 3.5, a second peak in the ClO2 absorbance is observed. In the CSTR, this iodine-free system displays simple and complex periodic oscillation, bistability, aperiodic oscillation, and birhythmicity.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170409
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetics and mechanism of the reaction between thiosulfate and chlorite ions at 90°CSystematic Design of Chemical Oscillators. Part 32. Part 31: M. Alamgir and I.R. Epstein, J. Phys. Chem., 89, 3611 (1985) (1986)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 18 (1986), S. 345-353 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the oxidation of S2O32- by ClO2- have been studied in aqueous alkaline solution at 900C using classical titrimetric methods to follow the course of the reaction. The reaction takes place according to the stoichiometry S2O32- + 2ClO2- + 2OH- = 2SO42- + 2Cl- + H2O even in large S2O32- excess. There is some indication of a complex reaction pattern, but 70% of the ClO2- disappearance can be best described by the autocatalytic rate equation -d[ClO2-]/dt = k[S2O32-] [ClO2-] [H+] with k = (1.3 ± 0.2) ×108 M-2 sec-1. The mechanism is explained by postulating nucleophilic attack of S2O32- on HClO2 to form a chlorine-containing intermediate.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550180307
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  • 6
    Electronic Resource
    Electronic Resource
    Autocatalysis and bistability in the reaction between nitric acid and thiocyanate (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 601-612 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction between nitric acid and thiocyanate has been studied both in batch and flow configurations. The batch reaction is autocatalytic with an induction period which is decreased by the addition of HNO2. At the nitric acid concentrations employed (1-10 M), a red NOSCNH+ intermediate is formed. The reaction in a flow reactor exhibits bistability. A model involving competitive reactions of SCN- and NOSCNH+ with NO2 is suggested, and computer simulations with this model give good agreement with both the batch and flow experiments.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170606
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