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  • 1
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    Bile acids: natural ligands for an orphan nuclear receptor (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear receptor. As ligands, these bile acids and their conjugates modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1. These results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, D J -- Blanchard, S G -- Bledsoe, R K -- Chandra, G -- Consler, T G -- Kliewer, S A -- Stimmel, J B -- Willson, T M -- Zavacki, A M -- Moore, D D -- Lehmann, J M -- F32 DK09793/DK/NIDDK NIH HHS/ -- R01 DK53366/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1999 May 21;284(5418):1365-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biochemistry, Glaxo Wellcome Research and Development, Research Triangle Park NC, 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334993" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bile Acids and Salts/chemistry/*metabolism/pharmacology ; Carrier Proteins/metabolism ; Cell Line ; Chenodeoxycholic Acid/*metabolism/pharmacology ; Cholesterol/metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Deoxycholic Acid/metabolism/pharmacology ; Histone Acetyltransferases ; Homeostasis ; Humans ; Ligands ; Lithocholic Acid/metabolism/pharmacology ; Mice ; Nuclear Receptor Coactivator 1 ; *Organic Anion Transporters, Sodium-Dependent ; Protein Conformation ; Receptors, Cytoplasmic and Nuclear/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Structure-Activity Relationship ; *Symporters ; Transcription Factors/chemistry/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-31
    Description: Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, D M -- Forsthuber, T -- Tary-Lehmann, M -- Etling, C -- Ito, K -- Nagy, Z A -- Field, J A -- Steere, A C -- Huber, B T -- R01 AR20358/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jul 31;281(5377):703-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Tufts University, Boston, MA 02111 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9685265" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Algorithms ; Amino Acid Sequence ; Animals ; Antigen Presentation ; Antigens, Surface/immunology/metabolism ; Arthritis, Reactive/drug therapy/*immunology ; Autoantigens/*immunology ; Autoimmune Diseases/*immunology ; Bacterial Outer Membrane Proteins/immunology/metabolism ; Bacterial Vaccines ; Borrelia burgdorferi Group/immunology ; Child ; Cross Reactions ; Female ; HLA-DR Antigens/genetics/immunology/metabolism ; HLA-DRB1 Chains ; Humans ; Immunodominant Epitopes ; *Lipoproteins ; Lyme Disease/drug therapy/*immunology ; Lymphocyte Function-Associated Antigen-1/chemistry/*immunology/metabolism ; Male ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Synovial Fluid/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Induction of TH1 and TH2 immunity in neonatal mice (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-03-22
    Description: The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (TH2) immune response. Thus, neonatal "tolerization" induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate TH2 or TH1 responses, depending on the mode of immunization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forsthuber, T -- Yip, H C -- Lehmann, P V -- AI36219-02/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Mar 22;271(5256):1728-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-4943, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; Antibody Formation ; Freund's Adjuvant ; *Immune Tolerance ; Immunization ; Immunoglobulin G/biosynthesis ; Immunologic Memory ; Lymph Nodes/immunology ; Mice ; Mice, Inbred BALB C ; Muramidase/immunology ; Spleen/immunology ; Th1 Cells/*immunology ; Th2 Cells/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrogen uptake of sorghum (Sorghum bicolor L.) from tree mulch and mineral fertilizer under high leaching conditions estimated by nitrogen-15 enrichment (1999)
    Springer
    Biology and fertility of soils 30 (1999), S. 90-95 
    Details
    ISSN: 1432-0789
    Keywords: Key words Agroforestry ; Mulch ; Nitrogen fertilizer ; Runoff irrigation ; Sorghum bicolor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  The effects of applying either inorganic fertilizer or leaf mulch of Acacia saligna (Labill.) H.L. Wend. on yields of Sorghum bicolor (L.) were compared with an unfertilized control under the high leaching conditions of runoff irrigation in a dry tropical environment. The N use efficiency and transfer from 15N-labelled (NH4)2SO4 or acacia leaves to the sorghum differed in quantity and quality. Only 6% of the applied mulch N was retrieved in the crop, in contrast to 21% of the fertilizer N. The proportions of N in the crop derived from the fertilizers were small, amounting to 7% and 28%, respectively, in the mineral fertilizer and mulch treatments. However, the application of inorganic fertilizer and mulch significantly increased crop grain yield (P〈0.05 and P〈0.1, respectively), biomass production and foliar N contents (P〈0.05). The inorganic fertilizer improved crop yields to a larger extent than mulching. At the same time, more N was lost by applying (NH4)2 SO4 than leaf mulch: only 37% of the N of applied (NH4)2 SO4 was found in the crop and the soil (0–0.3 m), but 99% of the mulched N. High NO3 – contents in the topsoil of the inorganic fertilized sorghum treatments indicated the risk of N leaching. However, more important may have been gaseous N losses of surface-applied NH4 +. From a nutrient conservation point of view, mulches should be given preferance to inorganic fertilizers under high soil pH and leaching conditions, but larger improvements of crop yields could be achieved with mineral fertilizers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050592
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  • 5
    Electronic Resource
    Electronic Resource
    Nutrient cycling in an agroforestry system with runoff irrigation in Northern Kenya (1998)
    Springer
    Agroforestry systems 43 (1998), S. 49-70 
    Details
    ISSN: 1572-9680
    Keywords: Acacia saligna ; nutrient balance ; nutrient leaching ; resin core ; soil solution ; Sorghum bicolor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A nutrient balance was determined for sole and alley cropped Sorghum bicolor and Acacia saligna in a runoff irrigation system in Northern Kenya. Nutrient input including precipitation and runoff, and output through harvest and leaching were measured for N, P, K, Ca and Mg using adsorption resins, tensiometry and suction cups. Various management scenarios are discussed with respect to nutrient return. Nutrient input with rainfall was generally low in comparison to nutrient uptake or leaching losses. The irrigation water, however, constituted an important nutrient input, especially for Ca and Mg. Nutrient export with the harvest was large for N and K, but can effectively be reduced by a nutrient return with mulch. Nutrient leaching losses from the topsoil (0–30 cm) were lower in the sorghum monoculture than in the tree-based systems. In the subsoil (120 cm), however, leaching was effectively reduced by the trees. In the agroforestry system, leaching losses of N under the sorghum were 53% lower than in the sorghum monoculture. This could be attributed to a higher root abundance and a higher ratio of nutrient uptake-to-leaching in the agroforestry system than in the monocultures indicating a higher nutrient efficiency. The lower leaching losses in the agroforestry system compared to the crop monoculture could not compensate for the additional nutrient export in tree biomass. A nutrient return by mulching crop residues and acacia leaves was essential for a positive nutrient balance in the agroforestry system. Combining annual and perennial crops provided a higher internal nutrient cycling than the monocultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026447119829
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  • 6
    Electronic Resource
    Electronic Resource
    Nutrient interactions of alley cropped Sorghum bicolor and Acacia saligna in a runoff irrigation system in Northern Kenya (1999)
    Springer
    Plant and soil 210 (1999), S. 249-262 
    Details
    ISSN: 1573-5036
    Keywords: Acacia saligna ; nutrient competition ; 15N ; resin core ; soil solution ; Sorghum bicolor ; Sr
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In a runoff irrigation system in Northern Kenya, we studied the nutrient interactions of sole cropped and alley cropped Sorghum bicolor (L.) Moench and Acacia saligna (Labill.) H.L. Wendl. The trees were pruned once before the cropping season and the biomass was used as fodder for animals. The nutrient contents in leaf tissue, soil and soil solution were monitored and the uptake of applied tracers (15N, Sr) was followed. The grain yield of alley cropped sorghum was similar to or slightly higher than in monoculture and did not decrease near the tree-crop interface. Foliar N and Ca contents of the crop were higher in the agroforestry combination than in monoculture, corresponding to higher soil N and Ca contents. Soil solution and soil mineral N dynamics indicate an increase of N under the tree row and unused soil N at the topsoil in the alley of the sole cropped trees as well as below 60 cm depth in the crop monoculture. The N use efficiency of the tree+crop combination was higher than the sole cropped trees or crops. Competition was observed for Zn and Mn of both tree and crop whereas for Ca only the tree contents decreased. P, K, Mg and Fe dynamics were not affected by alley cropping at our site. The lower uptake of applied Sr by trees in alley cropping compared to those of the monoculture stand suggested a lower competitiveness of the acacia than sorghum, which did not show lower Sr contents when intercropped. The study showed the usefulness of combining soil and plant analyses together with tracer techniques identifying nutrient competition, nutrient transfer processes and the complementary use of soil nutrients, as the main features of the tree-crop combination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004698403770
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  • 7
    Electronic Resource
    Electronic Resource
    Fine root turnover of irrigated hedgerow intercropping in Northern Kenya (1998)
    Springer
    Plant and soil 198 (1998), S. 19-31 
    Details
    ISSN: 1573-5036
    Keywords: Acacia saligna ; agroforestry ; nitrogen ; root decomposition ; root distribution ; root turnover ; Sorghum bicolor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Fine root turnover (〈2 mm) was determined from repeated measurements of root distribution up to 120 cm soil depth by core sampling in four month intervals. Sole cropped Sorghum bicolor and Acacia saligna were compared with the agroforestry combination in an alley cropping system in semiarid Northern Kenya. Three methods for the calculation of root production were used: the max-min, balancing-transfer and compartment-flow method. The highest root biomass was found in the topsoil for all cropping systems, though trees had a deeper root system. Trees and crops had a similar amount of below-ground biomass during the vegetation period (0.3 and 0.4 Mg DM ha-1 120 cm-1), but in the agroforestry combination root biomass was more than the sum of the sole cropped systems (1.1 Mg DM ha-1 120 cm-1). The tree system showed a very static root development with little fluctuation between seasons, whereas root biomasses were very dynamic in the crop and tree + crop systems. Root production was highest in the tree + crop combination with 2.1 Mg DM ha-1 a-1, with about 50% less in sole cropped trees and crops. Root N input to soil decreased in the order tree + crop〉tree〉crop system with 13.5, 11.0 and 3.2 kg N ha-1 a-1, and cannot be estimated from total below-ground biomass or carbon turnover, as N is accumulated in senescing roots. Such low N input to soil stresses the need for investigating other processes of nutrient input from roots to soil. Areas of highest N input were identified in the topsoil under the tree row in the tree system. Resource utilisation and C and N input to soil were highest with a combination of annual and perennial crops.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004293910977
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