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  • 1
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    Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1 (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-21
    Description: The sphingolipid metabolite sphingosine-1-phosphate (SPP) has been implicated as a second messenger in cell proliferation and survival. However, many of its biological effects are due to binding to unidentified receptors on the cell surface. SPP activated the heterotrimeric guanine nucleotide binding protein (G protein)-coupled orphan receptor EDG-1, originally cloned as Endothelial Differentiation Gene-1. EDG-1 bound SPP with high affinity (dissociation constant = 8.1 nM) and high specificity. Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, M J -- Van Brocklyn, J R -- Thangada, S -- Liu, C H -- Hand, A R -- Menzeleev, R -- Spiegel, S -- Hla, T -- DK45659/DK/NIDDK NIH HHS/ -- GM43880/GM/NIGMS NIH HHS/ -- HL49094/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Mar 6;279(5356):1552-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9488656" target="_blank"〉PubMed〈/a〉
    Keywords: Cadherins/*biosynthesis ; *Cell Aggregation ; Cell Differentiation ; Cell Line ; Cloning, Molecular ; GTP-Binding Proteins/metabolism ; Gene Expression ; Genes, Immediate-Early ; Humans ; Immediate-Early Proteins/genetics/*metabolism ; Intercellular Junctions/*ultrastructure ; Ligands ; *Lysophospholipids ; Mitogen-Activated Protein Kinase 1/metabolism ; Morphogenesis ; Receptors, Cell Surface/genetics/*metabolism ; *Receptors, G-Protein-Coupled ; Receptors, Lysophospholipid ; Signal Transduction ; Sphingosine/*analogs & derivatives/metabolism ; Transfection ; rho GTP-Binding Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of silver on electrochemical and corrosion behaviours of Pb–Ca–Sn–Al grid alloys Part I: Potentiodynamic and potentiostatic studies (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 1-6 
    Details
    ISSN: 1572-8838
    Keywords: lead acid battery ; grid alloy ; silver ; electrochemical behaviour ; corrosion behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The influence of silver, in the range of 0.02 wt% to 0.07 wt%, on the electrochemical and corrosion properties of Pb–Ca–Sn–Al grid alloy in sulphuric acid solutions at room temperature was investigated by potentiodynamic and potentiostatic methods. The introduction of Ag into a common grid alloy of Pb–Ca–Sn–Al confers some important features on the alloy. Potentiodynamic anodic polarisation measurements provided a qualitative overview of the activating, passivating and transpassivating processes which correspond to Pb → PbSO4, PbSO4 → PbO2 reactions respectively. Cyclic voltammetric measurements provided information on the effect of Ag on the oxidation of PbSO4 to PbO2. The addition of Ag refined the grains and enhanced the passivation of the electrode and its corrosion resistance. A decrease in the oxygen evolution overpotential and an increase in the hydrogen evolution overpotential with the additions of Ag were also observed during the experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003492329927
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of silver on electrochemical and corrosion behaviours of Pb–Ca–Sn–Al grid alloys Part II: A.c. impedance and scanning electron microscopy studies (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 177-183 
    Details
    ISSN: 1572-8838
    Keywords: corrosion ; grid alloy ; lead–acid batteries ; silver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The influence of silver, in the range of 0.02 to 0.07wt%, on the electrochemical and corrosion properties of Pb–Ca–Sn–Al grid alloy in sulphuric acid solutions at room temperature was investigated by electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). EIS was used to study the effect of silver on the surface layer(s) of an electrode under different conditions, while the oxide layers produced on the working electrode surface were examined by SEM. The addition of silver in the alloy inhibits the reactions of Pb to PbSO4 and PbSO4 to PbO2 and produces a more dense oxide layer which could enhance the corrosion resistance of the alloy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003469032404
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    Paper (German National Licenses)
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