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  • Life Sciences (General)  (2)
  • grid alloy  (2)
  • Humans
  • 1995-1999  (5)
  • 1
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    Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1 (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-03-21
    Beschreibung: The sphingolipid metabolite sphingosine-1-phosphate (SPP) has been implicated as a second messenger in cell proliferation and survival. However, many of its biological effects are due to binding to unidentified receptors on the cell surface. SPP activated the heterotrimeric guanine nucleotide binding protein (G protein)-coupled orphan receptor EDG-1, originally cloned as Endothelial Differentiation Gene-1. EDG-1 bound SPP with high affinity (dissociation constant = 8.1 nM) and high specificity. Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, M J -- Van Brocklyn, J R -- Thangada, S -- Liu, C H -- Hand, A R -- Menzeleev, R -- Spiegel, S -- Hla, T -- DK45659/DK/NIDDK NIH HHS/ -- GM43880/GM/NIGMS NIH HHS/ -- HL49094/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 Mar 6;279(5356):1552-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9488656" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cadherins/*biosynthesis ; *Cell Aggregation ; Cell Differentiation ; Cell Line ; Cloning, Molecular ; GTP-Binding Proteins/metabolism ; Gene Expression ; Genes, Immediate-Early ; Humans ; Immediate-Early Proteins/genetics/*metabolism ; Intercellular Junctions/*ultrastructure ; Ligands ; *Lysophospholipids ; Mitogen-Activated Protein Kinase 1/metabolism ; Morphogenesis ; Receptors, Cell Surface/genetics/*metabolism ; *Receptors, G-Protein-Coupled ; Receptors, Lysophospholipid ; Signal Transduction ; Sphingosine/*analogs & derivatives/metabolism ; Transfection ; rho GTP-Binding Proteins
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 2
    Digitale Medien
    Digitale Medien
    Influence of silver on electrochemical and corrosion behaviours of Pb–Ca–Sn–Al grid alloys Part I: Potentiodynamic and potentiostatic studies (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 1-6 
    Details
    ISSN: 1572-8838
    Schlagwort(e): lead acid battery ; grid alloy ; silver ; electrochemical behaviour ; corrosion behaviour
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The influence of silver, in the range of 0.02 wt% to 0.07 wt%, on the electrochemical and corrosion properties of Pb–Ca–Sn–Al grid alloy in sulphuric acid solutions at room temperature was investigated by potentiodynamic and potentiostatic methods. The introduction of Ag into a common grid alloy of Pb–Ca–Sn–Al confers some important features on the alloy. Potentiodynamic anodic polarisation measurements provided a qualitative overview of the activating, passivating and transpassivating processes which correspond to Pb → PbSO4, PbSO4 → PbO2 reactions respectively. Cyclic voltammetric measurements provided information on the effect of Ag on the oxidation of PbSO4 to PbO2. The addition of Ag refined the grains and enhanced the passivation of the electrode and its corrosion resistance. A decrease in the oxygen evolution overpotential and an increase in the hydrogen evolution overpotential with the additions of Ag were also observed during the experiments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1003492329927
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Influence of silver on electrochemical and corrosion behaviours of Pb–Ca–Sn–Al grid alloys Part II: A.c. impedance and scanning electron microscopy studies (1999)
    Springer
    Journal of applied electrochemistry 29 (1999), S. 177-183 
    Details
    ISSN: 1572-8838
    Schlagwort(e): corrosion ; grid alloy ; lead–acid batteries ; silver
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The influence of silver, in the range of 0.02 to 0.07wt%, on the electrochemical and corrosion properties of Pb–Ca–Sn–Al grid alloy in sulphuric acid solutions at room temperature was investigated by electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). EIS was used to study the effect of silver on the surface layer(s) of an electrode under different conditions, while the oxide layers produced on the working electrode surface were examined by SEM. The addition of silver in the alloy inhibits the reactions of Pb to PbSO4 and PbSO4 to PbO2 and produces a more dense oxide layer which could enhance the corrosion resistance of the alloy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1003469032404
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 4
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    Effects of microgravity on urinary osteopontin (1999)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: Increased risk of renal stone formation during space flight has been linked primarily to increased calcium excretion from bone demineralization induced by space flight. Other factors contributing to increased risk include increased urinary calcium oxalate supersaturation, while urinary citrate, magnesium and volume are all decreased. The aim of this study was to increase the predictive value of stone risk profiles for crew members during space flight by evaluating the excretion of urinary protein inhibitors of calcium crystallization so that more comprehensive stone risk profiles could relate mineral saturation to the concentrations of inhibitor proteins. Levels of urinary osteopontin (uropontin) are reported in a series of 14 astronauts studied before, during, and after space flights. During space flight, a compensatory increase in uropontin excretion was not observed. However, the uropontin excretion of a majority of astronauts was increased during the period after space flight and was maximal at 2 wk after landing. The downward shift in the molecular size of uropontin observed in samples obtained during space flight was shown to result from storage at ambient temperature during flight, rather than an effect of microgravity on uropontin synthesis.
    Schlagwort(e): Life Sciences (General)
    Materialart: Journal of the American Society of Nephrology : JASN (ISSN 1046-6673); 10 Suppl 14; S389-93
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 5
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    Composite x-ray image assembly for large-field digital mammography with one- and two-dimensional positioning of a focal plane array (1998)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: To demonstrate the feasibility of a novel large-field digital mammography technique, a 1024 x 1024 pixel Loral charge-coupled device (CCD) focal plane array (FPA) was positioned in a mammographic field with one- and two-dimensional scan sequences to obtain 950 x 1800 pixel and 3600 x 3600 pixel composite images, respectively. These experiments verify that precise positioning of FPAs produced seamless composites and that the CCD mosaic concept has potential for high-resolution, large-field imaging. The proposed CCD mosaic concept resembles a checkerboard pattern with spacing left between the CCDs for the driver and readout electronics. To obtain a complete x-ray image, the mosaic must be repositioned four times, with an x-ray exposure at each position. To reduce the patient dose, a lead shield with appropriately patterned holes is placed between the x-ray source and the patient. The high-precision motorized translation stages and the fiber-coupled-scintillating-screen-CCD sensor assembly were placed in the position usually occupied by the film cassette. Because of the high mechanical precision, seamless composites were constructed from the subimages. This paper discusses the positioning, image alignment procedure, and composite image results. The paper only addresses the formation of a seamless composite image from subimages and will not consider the effects of the lead shield, multiple CCDs, or the speed of motion.
    Schlagwort(e): Life Sciences (General)
    Materialart: Medical physics (ISSN 0094-2405); 25; 2; 172-5
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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